A5045841577- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Spaceflight effects on biology
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Bacterial biofilms and quorum sensing
- Space Exploration and Technology
- Wastewater Treatment and Nitrogen Removal
- Light effects on plants
- Biochemical and Structural Characterization
- Aerospace Engineering and Energy Systems
- Planetary Science and Exploration
- Viral gastroenteritis research and epidemiology
- bioluminescence and chemiluminescence research
- Biocrusts and Microbial Ecology
- Polar Research and Ecology
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2022-2024
University of Bonn
2020
Quickly identifying and characterizing isolates from extreme environments is currently challenging while very important to explore the Earth′s biodiversity. As these may, in principle, be distantly related known species, techniques are needed reliably identify branch of life which they belong. Proteotyping environmental by tandem mass spectrometry offers a rapid cost-effective option for their identification using peptide profiles. In this study, we document first high-throughput...
Melanins are complex pigments with various biological functions and potential applications in space exploration biomedicine due to their radioprotective properties. Aspergillus niger, a fungus known for its high radiation resistance, is widely used biotechnology candidate melanin production. In this study, we investigated the production of fungal pyomelanin (Pyo Fun ) A. niger by inducing overproduction pigment using L-tyrosine recombinant Δ hmgA mutant strain (OS4.3). The Pyo was...
A pink-coloured bacterium (strain KR32T) was isolated from cheese and assigned to the 'Arthrobacter agilis group'. Members of 'pink Arthrobacter group' form a stable clade (100 % bootstrap value) contain species agilis, ruber echini, which share ≥99.0 16S rRNA gene sequence similarity. Isolate KR32T showed highest similarity (99.9 %) A. DSM 20550T. Additional multilocus comparison confirmed assignment strain Average nucleotide identity digital DNA-DNA hybridization values between isolate...
Staphylococcus capitis naturally colonizes the human skin but as an opportunistic pathogen, it can also cause biofilm-associated infections and bloodstream in newborns. Previously, we found that two strains from subspecies S. subsp. produce yellow carotenoids despite initial species description, reporting this non-pigmented. In aureus, golden pigment staphyloxanthin is important virulence factor, protecting cells against reactive oxygen modulating membrane fluidity. study, used pigmented...
Previous studies have reported that spaceflight specific conditions such as microgravity lead to changes in bacterial physiology and resistance behavior including increased expression of virulence factors, enhanced biofilm formation decreased susceptibility antibiotics. To assess if induced physiological can manifest human-associated bacteria, we compared three relevant Staphylococcus capitis isolates (DSM 111179, ISS; DSM 31028, clean room; 113836; artificial gravity bedrest study) with the...
Aquatic ecosystems house a significant fraction of Earth’s biosphere, yet most prokaryotes inhabiting these environments remain uncultivated. While recently developed genome-resolved metagenomics and single-cell genomics techniques have underscored the immense genetic breadth metabolic potential residing in uncultivated Bacteria Archaea, cultivation microorganisms is required to study their physiology via systems, confirm predicted biochemical pathways, exploit biotechnological potential,...