A5101458683- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Artificial Intelligence in Healthcare and Education
- Carcinogens and Genotoxicity Assessment
- Electronic Health Records Systems
- Machine Learning in Healthcare
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Bone Tissue Engineering Materials
- Estrogen and related hormone effects
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Mycotoxins in Agriculture and Food
- Traditional Chinese Medicine Analysis
- Pluripotent Stem Cells Research
- Colorectal Cancer Screening and Detection
- Hormonal Regulation and Hypertension
- Cancer Cells and Metastasis
- Cardiac Ischemia and Reperfusion
- Healthcare Policy and Management
- Arsenic contamination and mitigation
- Oral and Maxillofacial Pathology
National Clinical Research Center for Digestive Diseases
2024
Shanghai Ninth People's Hospital
2021-2024
Shanghai Stomatological Hospital
2024
Shanghai Jiao Tong University
2021-2024
University of Arizona
2019-2023
Stomatology Hospital
2023
Sun Yat-sen University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2019
SUNY Polytechnic Institute
2015-2019
Jilin University
2019
While large language models (LLMs) such as ChatGPT and Google Bard have shown significant promise in various fields, their broader impact on enhancing patient health care access quality, particularly specialized domains oral health, requires comprehensive evaluation.
Abstract The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor has been considered as potential method to overcome supply shortages. Here, we report that functional erythrocytes can be efficiently produced cord (CB) CD34+ using bottle turning device culture system. Safety efficiency studies were performed in murine nonhuman primate (NHP) models. With the selected optimized conditions, one CB cell could induced produce up 200 million with...
Arsenic is ubiquitous in soil and water environments consistently at the top of Agency for Toxic Substances Disease Registry (ATSDR) substance priority list. It has been shown to induce toxicity even low levels exposure. One major routes exposure arsenic through drinking water. This review presents current information related distribution environment, resultant impacts on human health, especially diabetes, which one most prevalent chronic diseases, regulation water, approaches treatment both...
Cytochrome P450 oxidoreductase (POR) is required for drug metabolism by all microsomal cytochrome enzymes. The aim of this study was to investigate whether any the common single nucleotide polymorphisms (SNPs) in <i>POR</i> gene and its flanking intergenic sequences correlate with interindividual variations warfarin maintenance dose (which determined partly rates metabolism) patients undergoing anticoagulation therapy. Warfarin patients9 demographic clinical information were collected from...
Abstract Because of a lack platelet supply and U.S. Food Drug Administration-approved growth factor, megakaryocytes have emerged as an effective substitute for alleviating thrombocytopenia. Here, we report the development efficient two-stage culture system that is free stroma, animal components, genetic manipulations production functional from hematopoietic stem cells. Safety studies were performed in murine nonhuman primate models. One human cryopreserved cord blood CD34+ cell could be...
Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number functional HSCs hinders successful transplantation. The purpose our current study is develop a new and cost-efficient medium formulation that could greatly enhance expansion while retaining their long-term repopulation hematopoietic properties for effective clinical Enriched human CD34+ cells mobilized nonhuman primate peripheral were expanded with new,...
With rapid economic growth and aging, hospital inpatient emergency services utilization has grown rapidly, emphasized an urgent requirement to adjust optimize the structure of health service utilization. Studies have shown that primary care is effective way reduce room (ER) This study aims examine whether middle-aged elderly individuals who selected outpatient in last month had less ER than those hospitals via self-referral system. Data were obtained from four waves nationally representative...
Abstract The effect of variations in the expression cytochrome P450 reductase (CPR or POR) is determined mice with decreased POR to identify potential vulnerabilities people low expression. There an age-dependent appearance increasing vacuolization proximal tubules renal cortex 4- 9-month-old male (but not female) Cpr-low (CL) mice. These have all cells body and upregulation lysosome-associated membrane protein 1 cortex. Vacuolization also seen extrahepatic CL extrarenal mice, but...
Abstract The bacteria-mediated inflammatory conditions adversely affect the osseointegration process of endosseous implants, which can even lead to implant malfunction or failure. Local drug delivery has been designed exert anti-inflammatory and antibacterial activities, but whether this strategy an effect on compromised under inflammation rarely studied. present study focused osteoinductive efficacy two known phytoestrogens [bergapten (BP) quercetin (QE)] sites multiple bacteria-infected in...
The effects of flavone (2-phenyl-1,4-benzopyrone), a modulator the cytochrome P-450 monooxygenase system, on myocardial postischemic reperfusion recovery were examined in present study. Left ventricular functional was evaluated isolated, crystalloid-perfused rabbit hearts after 2 hours modestly hypothermic (34 degrees C) global ischemia. Four groups (n = 8 each group) studied and compared: vehicle control group, second group pretreated with (8 x 10(-6) mol/L) before ischemia, third followed...
The nasal mucosa of some mammalian species are susceptible to the toxicity aflatoxin B1 (AFB1), a potent hepato-carcinogen, but little is known about enzymes involved in metabolic activation AFB1 or metabolites produced. In present study, metabolism was studied with microsomes from rats and rabbits several purified isozymes rabbit P450 reconstituted enzyme system. rates AFB1-N7-guanine DNA adduct formation rat over 3- 10-fold higher, respectively, than liver same species. On other hand, AFM1...
Abstract Rationale: The traditional maxillary sinus floor elevation has serious postoperative complications and long healing periods, for patients with insufficient residual bone height (RBH). endoscopic technique improves the blind nature of procedure. Platelet-rich fibrin (PRF) can promote tissue prevent perforation. Patient concern: A 25-year-old female roots in right second molar visited our hospital dental implants. Diagnose: CBCT results showed a low-density shadow at root tip,...
Cytochrome P450 reductase (CPR or POR) is an obligatory redox partner for all microsomal enzymes. A large, global decrease in POR expression, a Cpr‐low mouse model, was previously found to lead altered sex steroid hormone homeostasis, female infertility, and decreased capacity xenobiotic metabolism. The aim of this study further characterize the order identify additional phenotypes that may reveal vulnerability people with low expression. Here we report age‐dependent appearance marked...
<sec> <title>BACKGROUND</title> While large language models (LLMs) such as ChatGPT and Google Bard have shown significant promise in various fields, their broader impact on enhancing patient health care access quality, particularly specialized domains oral health, requires comprehensive evaluation. </sec> <title>OBJECTIVE</title> This study aims to assess the effectiveness of Bard, ChatGPT-3.5, ChatGPT-4 offering recommendations for common issues, benchmarked against responses from human...