A5081562076- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Carbohydrate Chemistry and Synthesis
- Chromosomal and Genetic Variations
European Molecular Biology Laboratory
2021-2025
The reversible glycosylation of nuclear and cytoplasmic proteins (O-GlcNAcylation) is catalyzed by a single enzyme, namely O-GlcNAc transferase (OGT). mammalian Ogt gene X-linked, it essential for embryonic development the viability proliferating cells. We perturbed OGT’s function in vivo creating murine allelic series four amino acid substitutions, reducing catalytic activity to range degrees. severity lethality was proportional extent impairment catalysis, demonstrating that modification...
Abstract Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist , an X-linked long non-coding RNA (lncRNA). At the onset chromosome inactivation (XCI), is up-regulated and spreads along future inactive chromosome. Contextually, it recruits repressive histone DNA modifiers that transcriptionally silence regulation tightly coupled to differentiation its expression under control both pluripotency...
Abstract The reversible glycosylation of nuclear and cytoplasmic proteins (O-GlcNAcylation) is catalyzed by a single enzyme, namely O-GlcNAc transferase (OGT). mammalian Ogt gene X-linked it essential for embryonic development the viability proliferating cells. We perturbed OGT’s function in vivo creating murine allelic series four amino acid substitutions reducing catalytic activity to range degrees. severity lethality was proportional degree impairment catalysis, demonstrating that...