A5077729424- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Voice and Speech Disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Virus Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cervical Cancer and HPV Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Tracheal and airway disorders
- Cancer Cells and Metastasis
- Photodynamic Therapy Research Studies
- Dermatological and COVID-19 studies
- Skin Protection and Aging
Universidad de La Frontera
2018-2025
University of Bologna
2024
Millennium Institute on Immunology and Immunotherapy
2022
Fundação Oswaldo Cruz
2012-2017
Universidade Estadual Paulista (Unesp)
2000
Abstract The Epstein-Barr virus (EBV) infects more than 90% of the human population, playing a key role in origin and progression malignant non-malignant diseases. Many attempts have been made to classify EBV according clinical or epidemiological information; however, these classifications show frequent incongruences. For instance, they use small subset genes for sorting strains but fail consider enormous genomic variability abundant recombinant regions present genome. These could lead...
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. GC's most used chemotherapeutic regimen based on platinum drugs such as cisplatin (CDDP). However, CDDP chemoresistance reduces the survival rate advanced GC. The immune C-C chemokine receptor type 5 (CCR5) have been proposed pivotal factor in progression since its blockade has linked with antineoplastic effects tumor cell proliferation; nevertheless, role GC not elucidated. This study aimed to determine induced by...
Background and Objectives The aim of this study was to examine the salivary microbiome in healthy peri-implant sites those with peri-implantitis. Methods Saliva samples were collected from 21 participants V4 hypervariable region 16S rRNA gene sequenced using Ion Torrent PGM System (Ion 318™ Chip v2 400). NGS analysis composition determined by taxonomy assignment. Downstream bioinformatic analyses performed QIIME (v 1.9.1). Results Clinical differences according condition status found. Alpha...
Colorectal cancer is a heterogeneous disease caused by both genetic and epigenetics factors. Analysing DNA methylation changes occurring during colorectal progression metastasis formation crucial for the identification of novel epigenetic markers patient prognosis. Genome-wide sequencing paired samples colon (normal adjacent, primary tumour lymph node metastasis) showed global hypomethylation CpG island (CGI) hypermethylation tumours compared to normal. In we observed high non-CGI regions...
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that emerged in Brazil by late 2014. In the country, two CHIKV foci characterized East/Central/South Africa and Asian genotypes, were established North Northeast regions. We characterized, phylogenetic analyses of full partial genomes, from Rio de Janeiro state (2014-2015). These strains belong to genotype, which determinant current Northern Brazilian focus, even though genome sequence presents particular single nucleotide variations....
Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen based on carboplatin (CBDCA). However, CBDCA resistance the main obstacle to better prognosis. An vitro drug-resistant cell model would help understanding molecular mechanisms underlying this drug-resistance phenomenon. aim study was characterize cellular and changes induced CBDCA-resistant ovarian line A2780. selection strategy dose-per-pulse method using concentration...
Parvovirus B19 (B19V) infects individuals worldwide and is associated with an ample range of pathologies clinical manifestations. B19V classified into three distinct genotypes, all identified in Brazil. Here, we report a complete sequence genotype 1A that was obtained by high-throughput metagenomic sequencing. This genome provides information will contribute to the studies on epidemiology evolution.
Photodynamic therapy (PDT) has been used to treat certain types of non-melanoma skin cancer with promising results. However, some lesions have not fully responded this treatment, suggesting a potential PDT-resistant phenotype. Therefore, novel therapeutic alternatives must be identified that improve PDT in resistant cancer. In study, we analyzed the cell viability, intracellular protoporphyrin IX (PpIX) content and subcellular localization, proliferation profile, death, reactive oxygen...
The lifetime risk of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development differs among ethnic groups. To better understand these differences, this prospective cohort study was conducted to investigate the cytokine profile and HTLV-1 proviral load (PVL) in Japanese non-Japanese populations with HAM/TSP asymptomatic carriers (ACs). serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ levels were quantified using Cytometric Bead Array 40 HTLV-1-infected patients (11 29...
ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes recognized. However, there complete genomes only from the HTLV-1a (cosmopolitan) HTLV-1c (Melanesian) subtypes. Here, first full-length genome of an HTLV-1b strain, subtype so far restricted to Central African countries, revealed. The size SF26, strain isolated in Brazil, was determined be 8,267 bp. genomic analysis showed all...
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. The most used chemotherapeutic regimen in GC based on platinum drugs such as cisplatin (CDDP). However, CDDP resistance reduces advanced survival. In vitro drug-resistant cell model would help the understanding molecular mechanisms underlying this drug-resistance phenomenon. aim study was to characterize new models CDDP-resistant lines (AGS R-CDDP and MKN-28 R-CDDP) obtained through stepwise increasing drug doses...
Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker immune function solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation. Additionally, for latter one, TTV-DNA quantification saliva has also been suggested. to investigate correlation between TTV paired samples patients on kidney was quantified from 71 before short-time after renal-transplantation by real-time PCR. The data obtained 213 showed slight...
We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 CV79). This is one major determinants HTLV-1 infections in North West Africa, recombinant strains involving this have been recently demonstrated. The CV21 CV79 from Cape Verde/Africa were as pure genomes, comparative analyses including subtypes subgroups revealed signatures envelope, pol, pX regions. These provide original information that will contribute to further...
Human T-cell lymphotropic virus type 1 (HTLV-1) is a globally-spread virus. It estimated that there are about 5–10 million infected people in the world. HTLV endemic Chile, with higher seroprevalence among indigenous people. However, little known HTLV-1 genetic diversity, its introduction and dispersion this country. To gain insights into these issues, phylogenetic dating analysis was conducted based on Chilean closed related long terminal repeat sequences. The time tree reconstruction...
The Epstein–Barr virus (EBV) is a globally dispersed pathogen involved in several human cancers of B-cell and non-B-cell origin. EBV has been classified into EBV-1 EBV-2, which have differences their transformative ability. can transform B-cells LCL more efficiently than EBV-2 preferentially infects T-cell lymphocytes. EBNA3A oncoprotein transcriptional regulator host cell genes, required order to B-cells. six peptide motifs called nuclear localization signals (NLSs) that ensure...
Introducción: El virus del papiloma humano de alto riesgo (VPH-AR) es responsable cáncer cuello uterino y sus lesiones preneoplásicas. Los genotipos VPH16 VPH18 son los más frecuentes en este cáncer. La integración VPH-AR el genoma la célula hospedera crucial carcinogénesis cervical, pero etapa que ocurre población chilena incierta.
The Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and world. Little is known about Chilean EBV strains. This study aims to investigate frequency genetic diversity GC patients southern Chile. To evaluate prevalence from population, we studied 54 samples using gold standard detection method EBV-encoded small RNA (EBER). EBV-positive were subjected amplification sequencing nuclear protein 3A (EBNA3A) gene strains circulating In...