A5058327038- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Multiple Sclerosis Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Thyroid Disorders and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Mesenchymal stem cell research
- Neuroendocrine regulation and behavior
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- Wound Healing and Treatments
- Vestibular and auditory disorders
- Spinal Cord Injury Research
- Laser Applications in Dentistry and Medicine
- Neurological Disease Mechanisms and Treatments
University of Bologna
2015-2025
Fondazione IRET ONLUS
2012-2023
Chiesi (Italy)
2020
Technologies pour la Santé
2011-2020
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2016
University of Milan
1990-2012
Istituto Nazionale Biostrutture e Biosistemi
2009
BioPharm (United Kingdom)
2009
Hesperia Hospital
1995-2005
Morpho (United States)
2000-2004
In postnatal tissues, angiogenesis occurs in nontumoral conditions on appropriate stimuli. the nervous tissue, hypoxia, neural graft, increased function, and synaptic activity are associated with neoangiogenesis. We have investigated occurrence of neoangiogenesis superior cervical ganglia (scg) newborn rats treated for 8–21 days 6-hydroxy-dopamine (6-OHDA), nerve growth factor (NGF), or 6-OHDA + NGF. The two latter treatments induced a significant increase scg size. However, after combined...
Remyelination in the adult central nervous system has been demonstrated different experimental models of demyelinating diseases. However, there is no clear evidence that remyelination occurs multiple sclerosis, most diffuse disease. In this article, we explore possibility promoting myelination allergic encephalomyelitis, a widely used model by recruiting progenitors and channeling them into oligodendroglial lineage through administration thyroid hormone (T4). A large number proliferating...
Chronic disabilities in multiple sclerosis are believed to be due neuron damage and degeneration, which follow remyelination failure. Due the presence of numerous oligodendrocyte precursors inside demyelination plaques, one reason for failure could inability precursor cells turn into myelinating oligodendrocytes. In this study, we show that thyroid hormone enhances accelerates an experimental model chronic demyelination, i.e., allergic encephalomyelitis congenic female Dark Agouti rats...
Proliferating cells in the subventricular zone (SVZ) of adult rat brain could provide a source for repair attempts during degenerative diseases. However, very few reports dealt with spontaneous regulation this cell population experimental conditions. In paper, we describe an increase proliferation activity SVZ allergic encephalomyelitis, demyelinating disease widely used as model human multiple sclerosis. Moreover, p75 LNGFR -immunoreactive elements were larger encephalomyelitis compared...
Nitric oxide synthesizing (NOS) enzyme has been localized in distinct neural populations, including the hypothalamic paraventricular nucleus (PVN). Using situ hybridization, we have investigated possible changes NOS mRNA PVN of young and old rats after 2 h immobilization stress. In a 3-fold increase was observed immediately stressor, whereas reached significance when animals were killed 3 end stress procedure. The present results suggest that nitric may be involved response. differences...
A growing number of studies provided the evidence that human decidua is a pregnancy-related tissue capable hormone production and metabolism. The aim presentstudy was to evaluate possible presence inhibin subunits in decidua. Tissue samples were collected pregnant women during first (8 weeks) second trimester (18 gestation at term (40 weeks). Immunohistochemical data obtained using affinity purified polyclonal antisera raised rabbit against porcine α, βA, or βB subunits. Levels respective...
Clinical symptoms in multiple sclerosis include cognitive dysfunction. Difficulties learning and remembering new information represent the most common deficit are associated with a general progressive brain pathology. Possible pathogenetic mechanisms for neuronal damage such as neuroprotective strategies under active investigation also experimental allergic encephalomyelitis, widely used model sclerosis. In this paper we demonstrate that selective memory performance, investigated by Morris...
Considerable interest has been aroused in recent years by the well-known notion that biological systems are sensitive to visible light. With clinical applications of radiation far-red near-infrared region spectrum mind, we explored effect coherent red light irradiation with extremely low energy transfer on a neural cell line derived from rat pheochromocytoma. We focused pulsed laser vis-à-vis two distinct effects: neurite elongation under NGF stimulus laminin-collagen substrate and viability...
The effects of compounds interfering with γ-secretase, the enzymatic complex responsible formation amyloid-β (Aβ) peptide from protein precursor (AβPP), on plaque deposition in transgenic mouse models Alzheimer's disease ar
Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibrillary tangles, but primary cause only partially understood. Thus, there growing interest in developing agents that might target multiple mechanisms leading to degeneration. CHF5074 nonsteroidal anti-inflammatory derivative has been shown behave as γ-secretase modulator vitro inhibit...
Experimental allergic encephalomyelitis (EAE) is the most commonly used experimental animal model for human multiple sclerosis (MS) that has been so far to study acute and remission-relapsing phases of disease. Despite vast literature on neuroinflammation onset progression in EAE, important questions are still open regarding particular early asymptomatic phase between immunization clinical onset. In this study, we performed a time-course investigation demyelination biomarkers spinal cord...
Nerve growth factor (NGF) is a pleiotropic molecule acting on different cell types in physiological and pathological conditions. However, the effect of NGF survival, differentiation maturation oligodendrocyte precursor cells (OPCs) oligodendrocytes (OLs), responsible for myelin formation, turnover, repair central nervous system (CNS), still poorly understood heavily debated.Here we used mixed neural stem (NSC)-derived OPC/astrocyte cultures to clarify role throughout entire process OL...
Blood–brain barrier dysfunction (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an model multiple sclerosis (MS). We have previously shown that blocking microglial proliferation using GW2580, selective inhibitor CSF1R (Colony stimulating factor 1 receptor), reduced disease progression and severity prevented the relapse phase. However, whether this was due to effects GW2580 on functional integrity BBB not determined. Therefore, here, we examine properties...
Trophoblast and fetal membranes (amnion chorion) are the tissues forming anatomical/functional interface between mother fetus. The aim of present study was to evaluate presence a possible effect inhibin activin in human amnion chorion. expression inhibin/activin alpha, beta A, B subunit messenger RNA (mRNA) localization immunoreactive material were evaluated chorion collected at term pregnancy by Northern blot analysis immunohistochemistry. Amnion cells expressed mRNA three subunits, with...
Abstract Oligodendrocyte development and myelination are under thyroid hormone control. In this study we analysed the effects of chronic manipulation status on expression a wide spectrum oligodendrocyte precursor cells (OPCs) markers myelin basic protein (MBP) in subventricular zone (SVZ), olfactory bulb optic nerve, neural stem cell (NSC) lineage adult rats. Hypo‐ hyperthyroidism were induced male rats, by propyl‐thio‐uracil (PTU) l ‐thyroxin (T4) treatment, respectively. Hypothyroidism...