Daniela León

ORCID: 0009-0001-2349-0060
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About
Contact & Profiles
Research Areas
  • Photodynamic Therapy Research Studies
  • Skin Protection and Aging
  • Nanoplatforms for cancer theranostics
  • Orthopedic Surgery and Rehabilitation
  • Reproductive tract infections research
  • Adolescent Sexual and Reproductive Health
  • Phytochemicals and Antioxidant Activities
  • Peripheral Nerve Disorders
  • Reconstructive Surgery and Microvascular Techniques
  • Pelvic floor disorders treatments
  • Nerve Injury and Rehabilitation
  • Shoulder Injury and Treatment
  • Sex work and related issues
  • Cinema History and Criticism
  • Viral-associated cancers and disorders
  • Lymphoma Diagnosis and Treatment
  • Genital Health and Disease
  • Cytomegalovirus and herpesvirus research
  • Tea Polyphenols and Effects
  • Click Chemistry and Applications
  • Breast Implant and Reconstruction
  • Breast Cancer Treatment Studies
  • Cardiovascular Effects of Exercise
  • Cervical Cancer and HPV Research
  • Urinary Tract Infections Management

Millennium Institute on Immunology and Immunotherapy
2024

Universidad de La Frontera
2013-2024

Adolfo Ibáñez University
2023

Asociación Mexicana de Psicología y Desarrollo Comunitario
2023

Complejo Hospitalario Universitario de Albacete
2012

Photodynamic therapy (PDT) has been used to treat certain types of non-melanoma skin cancer with promising results. However, some lesions have not fully responded this treatment, suggesting a potential PDT-resistant phenotype. Therefore, novel therapeutic alternatives must be identified that improve PDT in resistant cancer. In study, we analyzed the cell viability, intracellular protoporphyrin IX (PpIX) content and subcellular localization, proliferation profile, death, reactive oxygen...

10.3390/ijms21093327 article EN International Journal of Molecular Sciences 2020-05-08

Photodynamic therapy (PDT) treats nonmelanoma skin cancer. PDT kills cells through reactive oxygen species (ROS), generated by interaction among cellular O

10.3390/ijms25168683 article EN International Journal of Molecular Sciences 2024-08-09

Frequency of Chlamydia trachomatis infection in a group women from Region Araucanía, ChileBackground: is the most commonly reported sexually transmitted bacterial worldwide.Between 70 and 90% are asymptomatic, however, untreated persistent infections can lead to development urethritis, pelvic inflammatory disease, infertility ectopic pregnancy.Aims: To determine C. frequency Chile, using quantitative real time PCR (qPCR) compare usefulness endocervical urine samples for detection.Methods: 87...

10.4067/s0716-10182013000600006 article EN Revista chilena de infectología 2013-12-01

Molecular detection of sexually transmitted agents in a symptomatic group men and its relationship with sexual behaviorBackground: Sexually infections (STIs) affect reproductive health millions men.Pathogens such as human papillomavirus (HPV), herpes simplex virus type 1 2 (HSV-1 y HSV-2), Chlamydia trachomatis, Mycoplasma genitalium, hominis Ureaplasma urealyticum are associated STIs.Aim: To detect pathogens STIs behavior.Methodology: DNA was obtained from exfoliated cells penis 20 were...

10.4067/s0716-10182016000500003 article EN Revista chilena de infectología 2016-10-01

A rare and seldom diagnosed condition: Parsonage-Turner Syndrome (acute brachial neuritis)El hombro doloroso es un motivo de consulta frecuente en centros Atención Primaria y urgencias hospitalarias pediátricas.Establecer correcto diagnóstico diferencial evitará la iatrogenia sobre el paciente.Presentamos caso Síndrome (también conocido como neuritis braquial aguda) que, aunque causa infrecuente doloroso, presenta una clínica muy sugestiva caracterizada por dolor agudo seguido síntomas...

10.4321/s1139-76322012000300007 article ES cc-by-nc-nd Pediatría Atención Primaria 2012-06-01

The Epstein–Barr virus (EBV) is a globally dispersed pathogen involved in several human cancers of B-cell and non-B-cell origin. EBV has been classified into EBV-1 EBV-2, which have differences their transformative ability. can transform B-cells LCL more efficiently than EBV-2 preferentially infects T-cell lymphocytes. EBNA3A oncoprotein transcriptional regulator host cell genes, required order to B-cells. six peptide motifs called nuclear localization signals (NLSs) that ensure...

10.3390/cancers13112569 article EN Cancers 2021-05-24

Abstract Introduction: Photodynamic therapy (PDT) is a treatment for non melanoma skin cancer. PDT kills cells through reactive oxygen species (ROS), produced by interaction between cellular O2 and an excited photosensitizer (PS) specific light. One of the most used PS in dermatology Protoporphyrin IX (PpIX) its precursor methyl aminolevulinate (MAL). MAL enters into converted to PpIX enzymes heme group synthesis pathway. The insertion ferrous iron forms molecule, which has no action. A...

10.1158/1538-7445.am2023-2845 article EN Cancer Research 2023-04-04

Abstract Introduction: Squamous skin cancer is one of the most common neoplasia worldwide and may be preceded by Bowen's disease (BD) Actinic Keratosis (AK). These preneoplastic lesions can treated with photodynamic therapy (PDT). PDT causes cell death mainly reactive oxygen species (ROS) produced through a combination O2, photosensitizer light. BD AK have well overcomes after PDT. However, high recurrence rates some been reported. Objective: To generate resistant cells to as an in vitro...

10.1158/1557-3125.cellcycle16-b30 article EN Molecular Cancer Research 2016-11-01

Abstract Non-melanoma skin cancer (NSCLC) is the most frequent in humans worldwide. Solar UV radiation main risk factor to NSCLC developing areas such as face, neck, arms, etc. Basal cell carcinoma and precursor lesions of squamous (SCC), actinic keratosis, Bowen’s disease, can be treated with Photodynamic Therapy (PDT). PDT consists applying a cream containing photosensitizer on lesion, then being irradiated light at specific wavelength. The used PS methyl aminolevulinate (MAL). Light...

10.1158/1538-7445.am2023-2422 article EN Cancer Research 2023-04-04

Este artículo propone un análisis comparado de dos obras cinematográficas: el documental francés Visages Villages (2017), codirigido por Agnès Varda junto al fotógrafo JR y largometraje Medianeras (2011), del director argentino Gustavo Taretto. El escrito aborda desde la hipótesis que ambos films registran relatan, medios audiovisuales, historias en las lo humano pierde su preeminencia sobre otras agencias. Esto no ocurriría solo como tema a nivel narrativo, sino también materialidades film...

10.53382/issn.2452-445x.738 article ES cc-by-nc-nd Revista de humanidades (Santiago En línea) 2023-07-01
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