A5015835387- Semiconductor materials and devices
- Cell Adhesion Molecules Research
- Economic theories and models
- Blood disorders and treatments
- Nanoparticles: synthesis and applications
- Copper Interconnects and Reliability
- Neutropenia and Cancer Infections
- Angiogenesis and VEGF in Cancer
- Mass Spectrometry Techniques and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Advanced Banach Space Theory
- Economic Theory and Institutions
- Credit Risk and Financial Regulations
- Advanced Proteomics Techniques and Applications
- Metallurgical Processes and Thermodynamics
- Semiconductor materials and interfaces
- 3D Printing in Biomedical Research
- Power Line Communications and Noise
- Metabolomics and Mass Spectrometry Studies
- Blood Coagulation and Thrombosis Mechanisms
- Graphite, nuclear technology, radiation studies
- Hemophilia Treatment and Research
- Chalcogenide Semiconductor Thin Films
- Risk Management in Financial Firms
- Social Policies and Healthcare Reform
University Hospital Bonn
2024
Fraunhofer Institute for Solar Energy Systems
2024
Karlsruhe Institute of Technology
1986-2022
Ludwig-Maximilians-Universität München
2021
GlobalFoundries (Germany)
2010-2018
Johannes Gutenberg University Mainz
1994-2016
Ministry of Labour, Employment and the Social and Solidarity Economy
2016
SMS Siemag (Germany)
2016
GlobalFoundries (United States)
2010-2013
Community Farm Alliance
2013
This paper presents the outcomes from a workshop of European Network on Health and Environmental Impact Nanomaterials (NanoImpactNet). During workshop, 45 experts in field safety assessment engineered nanomaterials addressed need to systematically study sets with specific metrics generate data set which would allow establishment dose-response relations. The group concluded that international cooperation worldwide standardization terminology, reference materials protocols are needed make...
Osteopontin (OPN) is an extracellular matrix protein that has been implicated in the interactions between tumor cells and host matrix, including those involved invasion spread of cells. Because joint destruction rheumatoid arthritis (RA) mediated by invasive growth synovial tissue through its attachment to cartilage, we examined expression OPN synovia patients with RA effect on production collagenase 1 fibroblasts articular chondrocytes.The messenger RNA (mRNA) from 10 was situ hybridization...
Endothelial cells (ECs) are very responsive to proinfiammatory cytokines. ECs stimulated by these substances increase expression of cell surface adhesion molecules, leading dramatically altered interactions with leukocytes. In interactions, E-selectin, intercellular molecule-1 (ICAM-1) and vascular (VCAM-1) suggested play the most important role. Recent evidence has diversity in responses from different regions system. Human umbilical vein (HUVECs) often used EC culture model, although there...
Heavy metal ions can be released by corroding metallic implants into the surrounding tissue. When they enter blood vessels some of them are carried proteins like albumin and taken up endothelial cells lining vessels. To study their involvement in inflammatory response we investigated heavy ion induced effects cultured human vascular (HUVECs). NiCl2 CoCl2 upregulate, especially concentrations 1 mM, expression adhesion molecules (e.g., E-selectin intercellular molecule-1), as well cytokines...
To measure myoglobin, a marker for myocardial infarction, directly in human serum, two-dimensional liquid chromatography combination with electrospray ionization mass spectrometry was applied as an analytical method. High-abundant serum proteins were depleted by strong anion-exchange chromatography. The myoglobin fraction digested and injected onto 60 mm × 0.2 i.d. monolithic capillary column quantitation of selected peptides upon spectrometric detection. addition known amounts to the sample...
Cultured mesothelial cells (HOMES) are very responsive to the proinflammatory cytokines, interleukin (IL)-l and tumor necrosis factor-α (TNF-α). E-selectin, ICAM-1 VCAM-1 known play an important role, because they presented by diverse cell types, for example endothelial (ECs), interact with coresponding ligands on white blood membranes. In this study, expression of ICAM-1, VCAM-1, E-selectin as well PECAM-1 cultured HOMES was studied over 5,24,48 72 h exposure IL-1 β, interferon-γ TNF-α....
Metastasis is a complicated multi-step process involving interactions between tumour cells, the extracellular matrix and vessel walls. Experimental observations suggest that leucocyte migration function could be suitable model in order to understand cell dissemination. In present report we show quantify production of free radicals by human malignant melanoma cells (St-ml12) means spectrophotometrical method, using an enzyme immunoassay reader. Endothelial activated polymorphonuclear...
Endothelial cells (EC) are very responsive to proinfiammatory cytokines, e.g. interleukin-1 (IL-1) and tumor necrosis factor α (TNFα), as well bacterial lipopolysaccharide. EC stimulated by these substances secrete chemotactic factors increase expression of cell adhesion molecules (CAM), leading dramatically altered interactions with leukocytes, granulocytes monocytes. In E-selectin, ICAM-1 VCAM-1 known play an important role, they presented the interact corresponding ligands on white blood...
Severe congenital neutropenia (SCN) is a rare, heterogeneous, primary immunodeficiency disorder characterized by early onset of severe bacterial infections. We here describe case SCN associating and neurodevelopmental delay. The girl was well until the age 9 months, when she suffered from an episode convulsion. Subsequently, developed several episodes superficial abscesses, oral ulcers otitis media. Further work-up revealed caused homozygous mutation (R86X) in antiapoptotic molecule HAX1....
This is the report of 66th a series workshops organised by European Centre for Validation Alternative Methods (ECVAM). The aims this workshop were: a) to review assessment relevance in validation process, and b) develop an approach use references validation. participants critically discussed objectives, methods limitations different approaches when using reference test methods, substances results context toxicological methods.
PECVD and PEALD of ruthenium films using RuEtcp2 as a precursor N2/H2/Ar plasma reducing agent were characterized. A self-adjusting process to overcome the previously reported inhibition Ru on TaN substrates was investigated. Ellipsometric modelling demonstrated providing information both film thickness estimated content. The physical properties PECVD/PEALD compared characteristics sputtered within categories resistivity, impurites, crystal structure, conformity Cu plating. As result,...
Recent studies have presented evidence that the processes of hypoxaemia and reperfusion are involved in several pathogenetic mechanisms atherosclerotic lesions. The ability to activate circulating white blood cells (WBCs) enhance WBC-endothelial cell (EC) interactions is suspected be a major factor deleterious vessel wall. Various groups suggested adhesion molecules (CAMs), such as ICAM-1, VCAM-1 E-selectin their leukocyte ligands intercellular activities relevant types. We studied effects...
Mesothelial cells are actively involved in inflammatory processes by expressing a set of cell adhesion molecules (CAMs). Transmigration leukocytes into inflamed tissues requires chemotactic stimulus and engagement platelet-endothelial molecule-1 (PECAM-1). To investigate the kinetics peritonitis, pure cultures mesothelial necessary. In previous studies, we have found that human (HOMES) show weak constitutive expression PECAM-1, which cannot be further stimulated cytokines. It is known all...