Na Chen

ORCID: 0009-0000-6115-2698
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About
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Research Areas
  • Inflammatory Bowel Disease
  • Gut microbiota and health
  • bioluminescence and chemiluminescence research
  • vaccines and immunoinformatics approaches
  • Microbial Fuel Cells and Bioremediation
  • Viral Infectious Diseases and Gene Expression in Insects
  • Systemic Lupus Erythematosus Research
  • Luminescence Properties of Advanced Materials
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Modular Robots and Swarm Intelligence
  • Electrocatalysts for Energy Conversion
  • Biosensors and Analytical Detection
  • Pancreatic and Hepatic Oncology Research
  • Helicobacter pylori-related gastroenterology studies
  • Nanocluster Synthesis and Applications
  • Molecular Communication and Nanonetworks
  • Trace Elements in Health
  • Metalloenzymes and iron-sulfur proteins
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Bacterial biofilms and quorum sensing
  • Photosynthetic Processes and Mechanisms
  • Gallbladder and Bile Duct Disorders
  • Photoreceptor and optogenetics research
  • Immune Cell Function and Interaction
  • Luminescence and Fluorescent Materials

Renmin Hospital of Wuhan University
2017-2024

Wuhan University
2017-2024

Hangzhou First People's Hospital
2024

Microbial communication can drive coordinated functions through sensing, analyzing and processing signal information, playing critical roles in biomanufacturing life evolution. However, it is still a great challenge to develop effective methods construct microbial system with behaviors. Here, we report an electron transfer triggered redox network consisting of three building blocks including router, optical verifier bio-actuator for metabolism regulation coordination. In the network,...

10.1038/s41467-023-42561-3 article EN cc-by Nature Communications 2023-10-26

Abstract Monitoring microbial metabolism is vital for revealing the mechanism of disease related to and providing guidance biomanufacturing processes optimization. However, it remains a grand challenge offer real‐time insights into owing complex dynamic process. In this paper, recent advances prospects optical biosensors including organic, genetic coding inorganic are briefly described monitoring metabolism. This paper points out that challenges remain in heterogeneity. We believe work will...

10.1002/cjoc.202200839 article EN Chinese Journal of Chemistry 2023-03-09

Background Imiquimod is a Toll-like receptor-7 agonist that regulates immunity and can be used as an immune adjuvant. Ulcerative colitis has close correlation with disorder. Aim To investigate the therapeutic effect of imiquimod on dextran sulfate sodium (DSS)-induced explore underlying mechanisms. Methods C57BL/6J C57 mice received 3% DSS for 7 days to induce ulcerative colitis. Groups were intraperitoneally injected dexamethasone (DXM, 1.5 mg/kg) or (IMQ, 30 at same time daily. During...

10.1371/journal.pone.0186138 article EN cc-by PLoS ONE 2017-10-19

Abstract Inspired by the natural responsive phenomena, herein multiple persistent luminescent Zn 1.2 Ga 1.6 Ge 0.2 O 4 :Ni 2+ (ZGGO:Ni) nanoparticles with near‐infrared (NIR) II emission peak ≈1330 nm derived from Ni doping through controlled synthesis based on hydrothermal method are obtained. The obtained NIR ZGGO:Ni can not only respond to temperature but also specific solvent stimulus. results demonstrate that luminescence intensity decreases in hydroxyl containing such as water (H 2 O)...

10.1002/adma.202416399 article EN Advanced Materials 2024-12-19

Endoscopic retrograde cholangiopancreatography (ERCP) is an important treatment for inoperable hilar cholangiocarcinoma (HCC). The aim of the present study as to evaluate clinical value three-dimensional visualization (3DV) and 3D printing (3DP) technologies ERCP in patients with HCC. data 15 HCC admitted were analyzed retrospectively, including 9 males 6 females. Thin-sliced computed tomography magnetic resonance (MRCP) acquired imported into Mimics Innovation Suite v17.0 software...

10.3892/etm.2018.5831 article EN Experimental and Therapeutic Medicine 2018-02-02

Programming precise and specific microbial intraspecies or interspecies interaction would be powerful for metabolic regulation, signal pathway mechanism understanding, therapeutic application. However, it is still of great challenge to develop a simple universal method artificially encode the interactions without interfering with intrinsic cell metabolism. Here, we proposed an extensible flexible framework nucleic acid strategy encoding upon self-assembly. With this spatial manipulation...

10.1126/sciadv.adr4399 article EN cc-by-nc Science Advances 2024-12-11

Abstract Objective The aim of the study was to investigate expression proteins in colonic tissues mice with ulcerative colitis (UC) by using isobaric tags for relative and absolute quantitation (iTRAQ), probe into pathogenesis UC, find potential biomarkers UC. Methods Forty C57 were randomly divided control model groups (20 each group). group administered dextran sulphate sodium (DSS) 7 consecutive days ad libitum induce acute colitis, colon tissue extracted on 8th day after successful...

10.1007/s10330-018-0317-7 article EN Oncology and Translational Medicine 2019-02-01
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