A5087352589- Renal and related cancers
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray Imaging Techniques
- Cancer Cells and Metastasis
- Handwritten Text Recognition Techniques
- Digestive system and related health
- Hedgehog Signaling Pathway Studies
Lund University
2023
Skåne University Hospital
2023
Abstract Purpose: While patients with intermediate-risk (IR) Wilms tumors now have an overall survival (OS) rate of almost 90%, those affected by high-stage diffuse anaplasia OS only around 50%. We here identify key events in the pathogenesis mapping cancer cell evolution over anatomic space tumors. Experimental Design: spatially mapped subclonal landscapes a retrospective cohort 20 using high-resolution copy-number profiling and TP53 mutation analysis followed clonal deconvolution...
<p>Supplementary Table 3. Table. Sample list with TP53 status. All 20 WT cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) IR= intermediate risk, BT= blastemal type, DA= diffuse anaplasia. Headings marked grey show sequencing results; wt=wild mut=mutation, NA= not annotated (i.e. sequenced), aa= amino acid, REF= reference nucleotide, ALT= alternative ref= number of...
<p>Supplementary Table 4. Segmental aberrations. All 20 Wilms tumor (WT) cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) For each genetic event following information is given: ploidy level (Ploidy), chromosome (chr), genomic start end positions, events annotated as gain, loss, CNNI (copy neutral imbalance) or homozygous length of aberration (bp), which chromosomal...
<p>Supplementary Table 2. Representativeness of study participants. Details on how the patients with Wilms tumor in present compare to general population diagnosed tumor.</p>
<div>Abstract<p>Purpose: While patients with intermediate-risk Wilms tumors (WT) now have an overall survival rate of almost 90%, those affected by high-stage diffuse anaplasia (DA) only around 50%. We here identify key events in the pathogenesis DA mapping cancer cell evolution over anatomic space WTs. Experimental Design: spatially mapped subclonal landscapes a retrospective cohort 20 WTs using high-resolution copy number profiling and <i>TP53</i> mutation analysis...
<p>Supplementary Table 1. Overview of the study cohort and clinical data. This table contains basic information, including age, sex, whether tumors were uni- or bilateral, histology, stage, risk group, treatment to which resection specimen analyzed was subjected to, final outcome record adverse events.</p>
<p>Supplementary Figure 1 Geographic overview of histological and genetic features.</p>
<p>Supplementary Figure 3. Relationship between anaplasia, copy number aberrations, regression and mitotic rate.</p>
<p>Supplementary Figure 2. Complexity of phylogenetic tree, comparing WT DA to IR and BT WT.</p>
<p>Supplementary Figure 2. Complexity of phylogenetic tree, comparing WT DA to IR and BT WT.</p>
<p>Supplementary Table 4. Segmental aberrations. All 20 Wilms tumor (WT) cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) For each genetic event following information is given: ploidy level (Ploidy), chromosome (chr), genomic start end positions, events annotated as gain, loss, CNNI (copy neutral imbalance) or homozygous length of aberration (bp), which chromosomal...
<p>Supplementary Table 1. Overview of the study cohort and clinical data. This table contains basic information, including age, sex, whether tumors were uni- or bilateral, histology, stage, risk group, treatment to which resection specimen analyzed was subjected to, final outcome record adverse events.</p>
<p>Supplementary Figure 1 Geographic overview of histological and genetic features.</p>
<p>Supplementary Figure 3. Relationship between anaplasia, copy number aberrations, regression and mitotic rate.</p>
<p>Supplementary Table 3. Table. Sample list with TP53 status. All 20 WT cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) IR= intermediate risk, BT= blastemal type, DA= diffuse anaplasia. Headings marked grey show sequencing results; wt=wild mut=mutation, NA= not annotated (i.e. sequenced), aa= amino acid, REF= reference nucleotide, ALT= alternative ref= number of...
<p>Supplementary Table 2. Representativeness of study participants. Details on how the patients with Wilms tumor in present compare to general population diagnosed tumor.</p>
<p>Supplementary Figure 1 Geographic overview of histological and genetic features.</p>
<p>Supplementary Table 4. Segmental aberrations. All 20 Wilms tumor (WT) cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) For each genetic event following information is given: ploidy level (Ploidy), chromosome (chr), genomic start end positions, events annotated as gain, loss, CNNI (copy neutral imbalance) or homozygous length of aberration (bp), which chromosomal...
<p>Supplementary Table 2. Representativeness of study participants. Details on how the patients with Wilms tumor in present compare to general population diagnosed tumor.</p>
<p>Supplementary Figure 2. Complexity of phylogenetic tree, comparing WT DA to IR and BT WT.</p>
<p>Supplementary Figure 3. Relationship between anaplasia, copy number aberrations, regression and mitotic rate.</p>
<p>Supplementary Table 1. Overview of the study cohort and clinical data. This table contains basic information, including age, sex, whether tumors were uni- or bilateral, histology, stage, risk group, treatment to which resection specimen analyzed was subjected to, final outcome record adverse events.</p>
<p>Supplementary Table 4. Segmental aberrations. All 20 Wilms tumor (WT) cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) For each genetic event following information is given: ploidy level (Ploidy), chromosome (chr), genomic start end positions, events annotated as gain, loss, CNNI (copy neutral imbalance) or homozygous length of aberration (bp), which chromosomal...
<p>Supplementary Table 3. Table. Sample list with TP53 status. All 20 WT cases and their corresponding samples are listed. ‘Sample position’ refers to the individual sample its position in a certain paraffin block (see Figure 1 for details.) IR= intermediate risk, BT= blastemal type, DA= diffuse anaplasia. Headings marked grey show sequencing results; wt=wild mut=mutation, NA= not annotated (i.e. sequenced), aa= amino acid, REF= reference nucleotide, ALT= alternative ref= number of...