A5038016931- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Esophageal Cancer Research and Treatment
- Cardiovascular Issues in Pregnancy
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Maternal and Perinatal Health Interventions
- Cancer Cells and Metastasis
- Neurological Complications and Syndromes
- Maternal and fetal healthcare
- Blood Coagulation and Thrombosis Mechanisms
- Moyamoya disease diagnosis and treatment
- Uterine Myomas and Treatments
- Fibroblast Growth Factor Research
- Cardiac Structural Anomalies and Repair
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Appendicitis Diagnosis and Management
- Lymphatic System and Diseases
- Ureteral procedures and complications
- Gastrointestinal Tumor Research and Treatment
- Chemotherapy-related skin toxicity
Nagoya University
2014-2025
Lund University
2020-2025
Toyota Memorial Hospital
2014-2022
Kyorin University
2011-2014
Mayo Clinic in Arizona
2013
Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum. Mesothelial cells (MCs) act as barriers in abdominal cavity, preventing adhesion of cells. However, patients with OvCa, they are transformed into cancer-associated mesothelial (CAMs) via mesenchymal transition and form favorable microenvironment for tumors promote metastasis. attempts restoring CAMs their original state have been limited. Here, we investigated whether inhibition restoration MCs by...
Abstract Background In ovarian cancer (OvCa), achieving complete resection (RO) in initial surgery is crucial for improving prognosis. However, patients with undetected microscopic metastasis post-RO often have poorer outcomes. This study explores prognostic factors OvCa who underwent RO surgery, focusing on the role of ascites cytology as an indicator peritoneal metastasis. Methods We analyzed data from 975 cases Tokai Ovarian Tumor Study Group database (1986–2019). Excluding without...
<title>Abstract</title> The impact on prognosis of neutrophil infiltration in the microenvironment ovarian cancer remains to be elucidated. In this study, we analyzed association between peritoneal metastasis and prognosis. Furthermore, correlation number peripheral blood neutrophils, degree neutropenia, vascular endothelial area, stromal cells. Thirty-four specimens each primary metastatic advanced with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, αSMA was...
Abstract Background Cesarean delivery rates are increasing globally with almost half of them occurring due to a previous delivery. A trial labor after (TOLAC) is considered safe procedure, but most eligible women instead undergo before 39 weeks gestation. Lack education about TOLAC often associated increased repeat Cesarean. To reveal the safety and feasibility TOLAC, we conducted this observational, prospective study women’s independent decisions. We aimed clarify relationship between their...
Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions an important aspect of EOC cells when they detach from the primary site ovary. However, mechanism remains underexplored. Our study aimed to reveal role chondroitin sulfate proteoglycan 4 (CSPG4) in a major focus on cell-cell interactions. We examined expression CSPG4 clinical samples and cell lines EOC. The proliferation, migration, invasion abilities knockdown were assessed. also...
Abstract Introduction Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing excessive activation of thrombin. rhTM potentially reduces morbidity and mortality in patients with sepsis-induced disseminated intravascular (DIC). However, efficacy obstetric DIC has not yet been established. We performed this study to examine whether administration was effective treatment for induced one or more underlying...
Adipocyte-rich omentum offers "good soil" for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report induction of adipocyte dedifferentiation by OvCa cells pro-tumorigenic effects resulted adipocyte-derived fibroblasts. We confirmed that malignant ascites promoted primary human obtained from surgical omental specimen into fibroblast...
Abstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in early stage of PTB. The aim this study was to investigate relationship Group B streptococcus (GBS) colonization, leading cause pregnancy, Methods This single-center, retrospective cohort utilized data from 2009 2017 obtained at TOYOTA Memorial Hospital....
Abstract Most patients with ovarian cancer experience recurrence and develop resistance to platinum-based agents. The diagnosis of platinum based on the platinum-free interval is not always accurate timely in clinical settings. Herein, we used laser ablation inductively coupled plasma mass spectrometry visualize distribution tissues at time debulking surgery after neoadjuvant chemotherapy 27patients advanced high-grade serous cancer. Two distinct patterns were observed. Type A (n = 16):...
Abstract Objective The clinical significance of a higher BMI on the prognosis ovarian cancer remains controversial; therefore, more detailed analysis is demanded. This study investigated impact peritoneum‐specific recurrence to clarify involvement adipose tissue in proliferation cells at sites peritoneal dissemination. Methods Among 4,730 patients with malignant tumors, 280 diagnosed International Federation Gynecology and Obstetrics (FIGO) stage IIB IIIC epithelial who underwent complete...
Abstract Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information currently available on the impact of positive patient prognoses under each clinical background. We herein investigated comprehensive epithelial OvCa and effectiveness additional therapeutic interventions, including complete staging surgery chemotherapy. Among 4730 malignant neoplasms, retrospectively identified multiple institutions, 1906 were...
The aim of the present study was to examine effects incomplete surgery and adjuvant chemotherapy on prognosis patients with intraoperative rupture capsulated stage I epithelial ovarian cancer (OvCa).A regional retrospective conducted between 1986 2019. Among 4,730 malignant tumors, 534 women International Federation Gynecology Obstetrics IA IC1 OvCa were eligible. Differences in survival outcomes examined tumors uterine preservation, complete-staging lymphadenectomy, investigated by an...
Ovarian cancer is an intractable disease that mostly diagnosed at advanced stage and has a high recurrence rate. The early development of characteristic peritoneal dissemination via ascites contributes to poor prognosis. Based on the "seed soil" theory, ovarian considered form disseminated tumor interacts with peritoneum; superficial mesothelial cells are structurally important. Thus far, we have reported cells, which originally ecological defenses, transform into cancer-associated allies...