A5009461822- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Complications and Syndromes
- Pharmacological Receptor Mechanisms and Effects
- Ovarian cancer diagnosis and treatment
- Lymphatic System and Diseases
- Endometrial and Cervical Cancer Treatments
- Stress Responses and Cortisol
- Intraperitoneal and Appendiceal Malignancies
- Maternal and fetal healthcare
- Moyamoya disease diagnosis and treatment
- Appendicitis Diagnosis and Management
- Uterine Myomas and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Memory and Neural Mechanisms
- Angiogenesis and VEGF in Cancer
- Hernia repair and management
Nagoya University
2014-2023
Toyota Memorial Hospital
2013-2022
Meijo University
1996-2018
Toyota Motor Corporation (Switzerland)
2015
Emory University
1987-1988
Cancer cell–derived extracellular vesicles (EVs) have unique protein profiles, making them promising targets as disease biomarkers. High-grade serous ovarian carcinoma (HGSOC) is the deadly subtype of epithelial cancer, and we aimed to identify HGSOC-specific membrane proteins. Small EVs (sEVs) medium/large (m/lEVs) from cell lines or patient serum ascites were analyzed by LC-MS/MS, revealing that both EV subtypes had proteomic characteristics. Multivalidation steps identified FRα,...
The effects of i.c.v. injection the mu-selective opioid receptor agonist DAMGO and its combination with endogenous kappa-opioid dynorphin A-(1-13) on memory processes were examined in mice, using spontaneous alternation performance associated working a Y-maze. (10 and/or 30 ng) impaired increased total arm entries, which are considered to reflect locomotor activity. beta-Funaltrexamine (5 micrograms, i.c.v.), antagonist, almost completely antagonized impairment induced by ng). Physostigmine...
Abstract Introduction Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing excessive activation of thrombin. rhTM potentially reduces morbidity and mortality in patients with sepsis-induced disseminated intravascular (DIC). However, efficacy obstetric DIC has not yet been established. We performed this study to examine whether administration was effective treatment for induced one or more underlying...
Abstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in early stage of PTB. The aim this study was to investigate relationship Group B streptococcus (GBS) colonization, leading cause pregnancy, Methods This single-center, retrospective cohort utilized data from 2009 2017 obtained at TOYOTA Memorial Hospital....
Hepatic infarction is an extremely rare and fatal complication associated with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. It can develop into fulminant failure, which increases both maternal neonatal mortality rates. A 34-year-old woman no remarkable past medical history developed eclampsia after delivery at 40 weeks of gestation. Imaging indicated massive hepatic rupture followed by cardiac arrest failure. Despite replacement therapy plasma exchange continuous...
The present study was designed to clarify whether opioid neuronal systems are involved in the beneficial effects of tachykinins such as neurokinin NK1 receptor agonist, substance P (SP), NK2 A (NKA), and NK3 senktide, on scopolamine-induced impairment spontaneous alternation performance mice. Intracerebroventricular injections SP (0.1 microgram), NKA (0.3 microgram) senktide (3 ng) inhibited scopolamine (1 mg/kg)-induced without influencing total arm entries, indicating antiamnesic...
A bstract : We examined whether dopamine D4 receptor is involved in morphine dependence mice. Mice pretreated with (10 mg/kg, s.c.) twice a day for 5 days showed withdrawal syndromes such as jumping, rearing, and forepaw tremors after the administration of naloxone (2 i.p.) on sixth day. Such mice exhibited significant elevation cAMP levels thalamus compared control L‐745,870 (1 i.p.), selective antagonist, day, significantly attenuated severity increase naloxone. These results suggest that...
Ovarian clear cell carcinoma (OCCC) has been treated with surgery and chemotherapy; however, the prognosis remains poor because of chemoresistance. Therefore, immunotherapies are attracting attention, including GPC3 peptide vaccine, which improves overall survival. However, response rate is limited there no sufficient predictive biomarkers that can identify responders before treatment. Our purpose was to circulating serum miRNAs as for vaccine. Eighty-four patients in a phase II trial...
The present study was carried out to determine the involvement of dopamine receptor subtypes D3 and D4, in discriminative stimulus effects cocaine rats trained discriminate 10 mg/kg from vehicle. (1-10 mg/kg) were dose-dependent. D2 agonist bromocriptine (1.25-20 R(+)-7-OH-DPAT (0.0001-0.3 produced (10 mg/kg)-like effects. Both antagonist GR103691 (1 D4 L745870 partially antagonized (0.3 mg/kg). (0.001 inhibited antagonistic on mg/kg), whereas drug enhanced combination with did not markedly...