A5020269386- Pregnancy and preeclampsia studies
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Endometrial and Cervical Cancer Treatments
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Maternal and Perinatal Health Interventions
- Intraperitoneal and Appendiceal Malignancies
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Blood Coagulation and Thrombosis Mechanisms
- Endometriosis Research and Treatment
- Neurological Complications and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Moyamoya disease diagnosis and treatment
- Neonatal and fetal brain pathology
- Appendicitis Diagnosis and Management
- RNA modifications and cancer
- Lymphatic System and Diseases
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
Nagoya University Hospital
2024-2025
Nagoya University
2014-2025
Toyota Memorial Hospital
2014-2024
Fujita Health University
2022
Mie University
2011
Kitasato University
1995
Histological chorioamnionitis (HCA) is a form of maternal immune activation (MIA) linked to an increased risk neurodevelopmental disorders in offspring. Our previous study identified impairments MIA mouse model mimicking HCA. Thus, this investigated the role CD11c+ microglia, key contributors myelination through IGF-1 production, pathology. In model, microglial population was significantly lower group than control on postnatal day 3 (PN3d). Furthermore, myelination-related protein levels...
( Int J Obstet Anesth . 58;2024:103957. https://doi.org/10.1016/j.ijoa.2023.103957) Postpartum hemorrhage (PPH) is a significant obstetric emergency that accounts for ∼20% of maternal deaths globally. In cesarean deliveries (CD), PPH often described as blood loss >1000 mL, with reported rates ranging from 4.8% to 30%. High-risk pregnancies, like those advanced age, assisted reproductive technology, multiple or placenta accreta spectrum disorders, are major contributors the rising PPH....
Abstract Background Cesarean delivery rates are increasing globally with almost half of them occurring due to a previous delivery. A trial labor after (TOLAC) is considered safe procedure, but most eligible women instead undergo before 39 weeks gestation. Lack education about TOLAC often associated increased repeat Cesarean. To reveal the safety and feasibility TOLAC, we conducted this observational, prospective study women’s independent decisions. We aimed clarify relationship between their...
Abstract Aim Prenatal maternal depression is known to affect the neurodevelopment of offspring. This study aimed investigate profile umbilical cord serum in mothers with major depressive disorder (MDD). Methods Liquid chromatography–tandem mass spectrometry (LC–MS) was conducted using from MDD ( n = 5) and controls (control, 5). The levels several differentially expressed proteins were compared between 10) control groups by enzyme‐linked immunosorbent assay. Results proteomic profiles...
Abstract Introduction Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing excessive activation of thrombin. rhTM potentially reduces morbidity and mortality in patients with sepsis-induced disseminated intravascular (DIC). However, efficacy obstetric DIC has not yet been established. We performed this study to examine whether administration was effective treatment for induced one or more underlying...
Adipocyte-rich omentum offers "good soil" for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report induction of adipocyte dedifferentiation by OvCa cells pro-tumorigenic effects resulted adipocyte-derived fibroblasts. We confirmed that malignant ascites promoted primary human obtained from surgical omental specimen into fibroblast...
Abstract Aims To evaluate the effect of vaginal bleeding on efficacy controlled‐release dinoprostone delivery system (PROPESS) for cervical ripening and factors affecting PROPESS in a Japanese clinical setting. Methods A total 100 term pregnant women whom was used due to an unfavorable cervix (Bishop score ≤ 6) were enrolled. We retrospectively investigated which factors, including bleeding, associated with success using logistic regression analysis. Moreover, acidity examined 24 selected...
Abstract Background Although infection and inflammation within the genital tract during pregnancy is considered a major risk factor for spontaneous preterm birth (PTB), there are few studies on association between vaginal microorganisms in early stage of PTB. The aim this study was to investigate relationship Group B streptococcus (GBS) colonization, leading cause pregnancy, Methods This single-center, retrospective cohort utilized data from 2009 2017 obtained at TOYOTA Memorial Hospital....
To investigate the mechanism underlying increased risk of subsequent neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated neurodevelopment offspring a preeclampsia rat model induced by administration N-nitro-L-arginine methyl ester (L-NAME) and identified unique protein signatures cerebrospinal fluid.Pregnant rats received an intraperitoneal injection L-NAME (250 mg/kg/day) during gestational days 15-20 establish model. Behavioral experiments (negative...
Weight gain during interpregnancy period is related to hypertensive disorders of pregnancy (HDP). However, in care/counseling, the unpredictability timing next conception and difficulties preventing age-related body weight must be considered while setting management goals. Therefore, we suggest considering annual change mass index (BMI). This study aimed clarify association between BMI changes HDP risk subsequent pregnancies. A multicenter retrospective data from 2009 2019 examined adjusted...
A 68-year-old-woman was referred to our hospital because of obstructive jaundice. The patient had itching, but no abdominal pain, fever, or weight loss. Laboratory tests showed elevated levels alkaline phosphatase (2035 U/L; normal 35 – 104 U/L), γ-glutamyltransferase (497 < 39 and bilirubin (16.8 mg/dL; 1.2 mg/dL). C-reactive protein (1.35 mg/L; 0.5 mg/L) tumor antigen CA 19-9 (960.8 37 U/L) were slightly raised. Abdominal computed tomography (CT) revealed enhanced wall thickening the...
Hepatic infarction is an extremely rare and fatal complication associated with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. It can develop into fulminant failure, which increases both maternal neonatal mortality rates. A 34-year-old woman no remarkable past medical history developed eclampsia after delivery at 40 weeks of gestation. Imaging indicated massive hepatic rupture followed by cardiac arrest failure. Despite replacement therapy plasma exchange continuous...
Weight change during the interpregnancy is related to gestational diabetes mellitus (GDM) in subsequent pregnancy. In care/counseling, timeframe for goal setting important, while timing of next conception unpredictable and preventing age-related body weight gain difficult. This study aimed investigate association between annual interpregnancy, which provide clearer timeframe, GDM pregnancies.
Abstract Aims To predict preterm birth (PTB) accurately, we conducted a comprehensive cytokine assay using cervicovaginal fluid (CVF) and evaluated the additive effects of levels on fetal fibronectin (fFN) test. Methods A total 645 CVF samples were collected from 256 asymptomatic pregnant women between 24 35 weeks gestation, exhibiting short cervix. After selection based specific criteria, 17 cytokines in 105 simultaneously measured multiplex assay. Multivariate logistic regression analysis...
Given the increasing recognition of importance postpartum follow-up care for women with a history hypertensive disorders pregnancy (HDP) to mitigate their future risk cardiovascular and metabolic diseases, here we aimed evaluate current status in Japan explore challenges its implementation.
Abstract Congenital diaphragmatic hernia (CDH) is a life‐threatening condition with high morbidity and mortality rates. The survival rate of neonates severe CDH reportedly only 10%–15%. However, prenatal prediction cases difficult, the discovery new predictive markers an urgent issue. In this study, we focused on microRNAs (miRNAs) in amniotic fluid‐derived small EVs (AF‐sEVs). We identified four miRNAs (hsa‐miR‐127‐3p, hsa‐miR‐363‐3p, hsa‐miR‐493‐5p, hsa‐miR‐615‐3p) AUC > 0.8 to classify...