A5085604472- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- HIV/AIDS drug development and treatment
- Cancer therapeutics and mechanisms
- Malaria Research and Control
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related gene regulation
- Berberine and alkaloids research
- Cancer Mechanisms and Therapy
- Innovative Microfluidic and Catalytic Techniques Innovation
Erasmus MC
2024-2025
Erasmus University Rotterdam
2023-2024
Somatic mutations in ARID1A (AT-rich interactive domain-containing protein 1A) are present approximately 25% of bladder cancers (BC) and associated with poor prognosis. With a view to discover effective treatment options for ARID1A-deficient BC patients, we set out identify targetable effectors dysregulated consequent deficiency. Integrative analyses depletion normal organoids data mining publicly available datasets revealed upregulation DNA repair cell cycle-associated genes loss identified...
Malaria, a major public health burden, is caused by
Malaria, a major public health burden, is caused by Plasmodium spp parasites that first replicate in the human liver to establish infection before spreading erythrocytes. Liver-stage malaria research has remained challenging due lack of clinically relevant and scalable vitro model liver. Here, we demonstrate organoids derived from intrahepatic ductal cells differentiated into hepatocyte-like fate can support maturation falciparum. The P. falciparum exoerythrocytic forms observed expressed...