A5092785641- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Vascular Tumors and Angiosarcomas
- Transgenic Plants and Applications
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Molecular Biology Techniques and Applications
Ministry of Health of the Russian Federation
2024-2025
Previously we discovered that among 15 DNA-binding plant secondary metabolites (PSMs) possessing anticancer activity, 11 compounds cause depletion of the chromatin-bound linker histones H1.2 and/or H1.4. Chromatin remodeling or multiH1 knocking-down is known to promote upregulation repetitive elements, ultimately triggering an interferon (IFN) response. Herein, using HeLa cells and applying fluorescent reporter assay with flow cytometry, immunofluorescence staining quantitative RT-PCR,...
Sarcomas of non-genital organs affect women 1.5–3 times less often than men. The mechanism such dimorphism is studied at various levels, mainly in the field influence on pathogenesis sex hormones and their receptors, effect which significantly related to histogenesis tumor, its localization, malignant transformation stage progression. Sex hormone receptors are found early stages tumor development lost during At same time, expression tumors different sometimes correlates with opposite...
Previously we discovered that among 15 DNA-binding plant secondary metabolites (PSMs) possessing anticancer activity, 11 compounds cause depletion of the linker histones H1.2 and/or H1.4 from chromatin fraction. Chromatin remodeling or multiH1 knocking-down is known to promote upregulation repetitive elements, ultimately triggering an interferon response. Herein, using HeLa cells and applying fluorescent reporter assay with flow cytometry quantitave RT-PCR, found PSMs depleting histones, 8...
Introduction . The active use of highly toxic chemotherapy in the treatment soft tissue sarcomas determines need to search for criteria and markers chemoresistance patients therapy. Aim. To study connection between tumor cell resistance expression levels apoptosis-regulating proteins (PUMA, PMAIP-1, PIDD-1, AIFM-2, Bax, GADD45a) primary cultures sarcomas. Materials methods. Primary were obtained using enzymatic digestion, death was evaluated resazurine assay. Gene measured real-time...
Treatment of highly malignant soft tissue sarcomas (STSs) requires multicomponent therapy including surgery, radiotherapy, and chemotherapy. Despite the advancements in targeted cancer therapies, cytostatic drug combinations remain gold standard for STS The lack algorithms personalized selection chemotherapy leads to unhelpful treatment chemoresistant tumors, causing severe side effects patients. goal our study is assess applicability vitro chemosensitivity/resistance assays (CSRAs)...