A5030030815- Cancer, Hypoxia, and Metabolism
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Inflammatory mediators and NSAID effects
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Click Chemistry and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics and Neurodevelopmental Disorders
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Redox biology and oxidative stress
The University of Texas MD Anderson Cancer Center
2011-2023
The University of Texas Health Science Center at Houston
2022
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to propensity metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) a proposed model for initiation metastasis. During EMT cell-cell adhesion reduced allowing cells dissociate and invade. Of EMT-associated transcription factors, ZEB1 uniquely promotes NSCLC disease progression. Here we apply two independent screens, BioID an Epigenome shRNA dropout screen, define interactors that...
Anaplastic lymphoma kinase (ALK) constitutes a part of the oncogenic fusion proteins nucleophosmin-ALK and echinoderm microtubule-associated protein like 4-ALK, which are aberrantly expressed in subset T-cell anaplastic large-cell non-small-cell lung cancer, respectively. The expression mutated, constitutively active ALK also occurs neuroblastoma tumors. is believed to play an important role promoting tumor survival. Nevertheless, mechanisms underlying cancer cells not completely known....
Abstract NPM‐ALK chimeric oncogene is aberrantly expressed in an aggressive subset of T‐cell lymphomas that frequently occurs children and young adults. The mechanisms underlying the oncogenic effects are not completely elucidated. Inducible nitric oxide synthase ( iNOS ) promotes survival maintains malignant phenotype cancer cells by generating NO , a highly active free radical. We tested hypothesis deregulated + lymphoma this lymphoma. In line with possibility, inhibitor scavenger...
Background Type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase induces significant oncogenic effects. Strategies to block IGF-IR signaling are being tested in clinical trials that include patients with aggressive solid malignancies. Mantle cell lymphoma is a B-cell neoplasm poor prognosis and tendency develop resistance. The expression potential significance of mantle not known.Design Methods We used reverse transcriptase polymerase chain reaction, quantitative real-time...
// Suraj Konnath George 1,* , Deeksha Vishwamitra 1,2,* Roxsan Manshouri 1,2 Ping Shi 3 and Hesham M. Amin 1 Department of Hematopathology, The University Texas D. Anderson Cancer Center, Houston, TX 2 Graduate School Biomedical Sciences, State Key Laboratory Bioreactor Engineering, East China Science Technology, Shanghai, * These authors contributed equally to this work Correspondence: Amin, email: Keywords : NPM-ALK, ASP3026, T-cell lymphoma, crizotinib, CHOP Received June 22, 2014...
// Mary E. Irwin 1 , Blake P. Johnson 1,2 Roxsan Manshouri 3 Hesham M. Amin and Joya Chandra Department of Pediatrics Research, The University Texas MD Anderson Cancer Center, Houston, TX, USA 2 Graduate School Biomedical Sciences at Hematopathology, Correspondence to: Chandra, email: Keywords : TKI-resistance, CML, NOX, Fyn, Egr-1 Received April 14, 2015 Accepted June 12, Published 23, Abstract Tyrosine kinase inhibitors (TKI) have improved CML response rates, some are effective against...
Epithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes gene promoter regions suppress the expression genes. ZEB1 has inconsistent molecular weights, which have been attributed post-translational modifications (PTMs). We performed mass spectrometry identified K811 acetylation as a novel PTM ZEB1. To define role regulating...
Abstract The primary oncogene associated with CML is BCR/ABL which controls proliferative and survival signaling a potent inducer of reactive oxygen species (ROS). ROS play both positive negative roles in proliferation survival; this dual nature has been exploited by leukemia cells to promote growth, genomic instability, drug resistance. However, the distinct molecular alterations that occur as result BCR/ABL-induced are not well described. BCR/ABL-targeted therapeutics have improved...
Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine with structural similarities to the insulin receptor. ALK physiologically expressed in neuronal cells at early stages of human development. Thereafter, expression largely limited malignant neoplasms including T-cell anaplastic large-cell (ALCL), non-small cell lung cancer (NSCLC), and neuroblastoma. It has been previously established that ALK, form chimeric proteins or constitutively activated mutants, plays central role...
<div>Abstract<p>Epithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes gene promoter regions suppress the expression genes. ZEB1 has inconsistent molecular weights, which have been attributed posttranslational modifications (PTM). We performed mass spectrometry identified K811 acetylation as a novel PTM ZEB1....
<p>S1. K811 acetylation is integral to ZEB1 molecular weight. S2. &tilde225 kDa band regulates protein stability. S3. facilitates ZEB1/NuRD interaction. S4. directs the complex bind at genomic promoters. S5. decreased epithelial expression levels. S6. RNA-seq reveals downregulates of genes. S7. in KO cells promotes lung adenocarcinoma migration and invasion. S8. enhances metastatic potential murine NSCLC cells.</p>
<div>Abstract<p>Epithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes gene promoter regions suppress the expression genes. ZEB1 has inconsistent molecular weights, which have been attributed posttranslational modifications (PTM). We performed mass spectrometry identified K811 acetylation as a novel PTM ZEB1....