A5029592452- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Ovarian cancer diagnosis and treatment
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Cancer therapeutics and mechanisms
- Protein Degradation and Inhibitors
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Neonatal Respiratory Health Research
- PARP inhibition in cancer therapy
- Protein Tyrosine Phosphatases
- Medicinal Plant Pharmacodynamics Research
- Nutrition, Genetics, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Chronic Myeloid Leukemia Treatments
- Reproductive System and Pregnancy
- Occupational and environmental lung diseases
Yakult Honsha (Japan)
2014-2024
Yakult Central Institute
2013-2024
Hiroshima University
2006-2008
Abstract The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator cancer cell proliferation, survival invasion. Aberrant STAT3 has been demonstrated in various malignant cancers. YHO‐1701 novel quinolinecarboxamide derivative generated from STX‐0119. Here, we examined the effect on evaluated antitumor activity as single agent combination. inhibited STAT3‐SH2 binding to phospho‐Tyr peptide selectively more potently than STX‐0119 biochemical assays....
Abstract Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell growth, survival, metastasis. STAT3 signaling is constitutively activated various types hematologic or solid malignancies. YHO-1701 has been developed as an orally available inhibitor. Herein, combination with molecular-targeted agents was evaluated. Additive synergistic effects were observed broad spectrum “combination treatment + line” pairs. Of particular interest the effect when...
Regulation mechanism of lung fibroblast proliferation remains unknown. To elucidate the key molecules in it, authors here established mortal and immortal nontransformed cell line/strains with elongated life span by telomerase reversetranscriptase gene transfection. Comparing expression profiles them, 51 genes were explored to be candidates responsible for regulation cellular fibroblasts. This set fibrobrast strains same origin different proliferative capacities may become useful model cells...
Metastatic brain tumors are regarded as the most advanced stage of certain types cancer; however, chemotherapy has played a limited role in treatment metastases. Here, we established murine models metastasis using cell lines derived from human metastatic tumors, and aimed to explore antitumor efficacy perifosine, an orally active allosteric Akt inhibitor. We evaluated effectiveness perifosine by it single agent ectopic orthotopic created injecting DU 145 NCI-H1915 into mice. Initially,...
Signal transducer and activator of transcription 3 (STAT3) plays key roles in regulating cancer cell proliferation, survival, metastasis. We aimed to determine the effects YHO-1701, an oral STAT3 inhibitor, ovarian (OC).
Abstract Background: Accumulating evidence reveals effectiveness of histone deacetylase (HDAC) inhibition in various types cancer, and resminostat is a novel oral HDAC inhibitor. In this study, we investigated the preclinical activity human non-small-cell lung cancer (NSCLC) cells, especially combination with docetaxel (DTX). Materials Methods: Anti-proliferative was evaluated 9 NSCLC cell lines vitro. Monolayers cultured cells were exposed to viability determined. The amount p21, acetylated...
Signal transducer and activator of transcription (STAT) 3 plays a key role not only in regulating variety biological properties, including survival, proliferation, metastasis cancer cells, but also modifying the tumor microenvironment to promote angiogenesis immunosuppression, rendering STAT3 valuable target cancer.
Abstract Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell growth, survival, metastasis. STAT3 signaling is constitutively activated various types hematologic or solid malignancies. YHO-1701 has been developed as an orally available inhibitor. Herein, combination with molecular-targeted agents was evaluated. Additive synergistic effects were observed broad spectrum “combination treatment + line” pairs. Of particular interest the effect when...
Abstract Background: Perifosine is an oral anticancer compound that inhibits the PH-domain of AKT, which frequently activated in human cancers including gastric cancer. In this study, mode action perifosine, especially association with mTOR, and antitumor activity combination paclitaxel were examined cancer cell lines. Materials Methods: The following lines used study: MKN1, MKN45, MKN74, AGS, NCI-N87. Monolayers cultured cells exposed to perifosine for 48 hours antiproliferative was...