A5102833364- Nanoparticles: synthesis and applications
- Effects of Radiation Exposure
- Microplastics and Plastic Pollution
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Tendon Structure and Treatment
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Circular RNAs in diseases
- Radiation Therapy and Dosimetry
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Recycling and Waste Management Techniques
- MicroRNA in disease regulation
First Affiliated Hospital of Wannan Medical College
2024
Second Military Medical University
2022-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Radiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF poor prognosis and limited therapeutic options available in clinic. Lactobacillus rhamnosus GG (LGG) advantaged widely used health promotion. However. Whether LGG applicable prevention of relative underlying mechanism poorly understood. Here, we reported unique comprehensive analysis the impact its' derived lncRNA SNHG17 on radiation-induced...
Abstract Ionizing radiation (IR) has been extensively used for cancer therapy, but the radioresistance hinders and undermines radiotherapy efficacy in clinics greatly. Here, we reported that spliceosomal protein thioredoxin‐like 4B (TXNL4B) is highly expressed lung tissues from patients with radiotherapy. Lung cells TXNL4B knockdown illustrate increased sensitivity to IR. Mechanistically, interacts RNA processing factor 3 (PRP3) co‐localizes nucleus post‐IR. Nuclear localization of PRP3...
Abstract The study aimed to investigate the regulatory mechanism of intracellular tension signaling in endplate chondrocytes and its impact on extracellular matrix synthesis. Human were subjected load using Flexcell FX‐5000™, changes phenotype, morphology, expression Hippo pathway α‐Catenin assessed through various techniques. Through overexpression YAP inhibition α‐Catenin, clarified regulation synthesis cartilage. In vitro‐cultured human significantly suppressed phenotype‐related genes...
Abstract Background Nano-Zinc oxide (Nano-ZnO) has been increasingly applied in agriculture, industry and biomedicine. However, the genotoxic effects of Nano-ZnO underlying mechanisms remain incompletely clear. Methods Human bronchial epithelial cell line (HBE) was used to observe on DNA damage repair-related proteins mesenchymal transition (EMT) by Western blotting. Then, CRISPR/cas9-based technique create p53 knockout (p53-KO) line. RNA-seq analysis performed uncover circular RNA (circRNA)...