A5036476043- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- DNA Repair Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Radiation Effects and Dosimetry
- PARP inhibition in cancer therapy
- Advanced Radiotherapy Techniques
- Plant Genetic and Mutation Studies
- Radiation Dose and Imaging
- Cell death mechanisms and regulation
- Neutrino Physics Research
- Particle Detector Development and Performance
- Connexins and lens biology
- Dental Anxiety and Anesthesia Techniques
- Radioactivity and Radon Measurements
- Per- and polyfluoroalkyl substances research
- Earthquake Detection and Analysis
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Systemic Sclerosis and Related Diseases
- Nanoparticle-Based Drug Delivery
- Air Quality and Health Impacts
Institute of Nuclear Physics, Polish Academy of Sciences
2015-2025
Jagiellonian University
2024
Medicina
2024
Institution of Engineering and Technology
2021
1 Military Clinical Hospital with Outpatient Clinic
2016-2017
Polish Academy of Sciences
2016
Cyclotron (Netherlands)
2015
The Cosmic Ray Extremely Distributed Observatory (CREDO) is a newly formed, global collaboration dedicated to observing and studying cosmic rays (CR) ray ensembles (CRE): groups of minimum two CR with common primary interaction vertex or the same parent particle. CREDO program embraces testing known CRE scenarios, preparing observe unexpected physics, it also suitable for multi-messenger multi-mission applications. Perfectly matched capabilities, could be formed both within classical models...
Significant progress has been made in the technological and physical aspects of dose delivery distribution proton therapy. However, mode cell killing induced by protons is less understood comparison with X-rays. The purpose this study to see if there any difference cell-killing, X-rays an ex vivo human peripheral blood lymphocyte (HPBL) model.HPBL were irradiated 60 MeV beam or 250-kVp range 0.3-4.0 Gy. Frequency apoptotic necrotic cells was determined Fluorescein (FITC)-Annexin V labelling...
The integrity of the chromatin structure is essential to every process occurring within eukaryotic nuclei. However, there are no reliable tools decipher molecular composition metaphase chromosomes. Here, we have applied infrared nanospectroscopy (AFM-IR) demonstrate difference between eu- and heterochromatin generate maps single chromosomes revealing detailed information on their composition, with nanometric lateral spatial resolution. AFM-IR coupled principal component analysis has...
Gamification is known to enhance users’ participation in education and research projects that follow the citizen science paradigm. The Cosmic Ray Extremely Distributed Observatory (CREDO) experiment designed for large-scale study of various radiation forms continuously reach Earth from space, collectively as cosmic rays. CREDO Detector app relies on a network involved users now working worldwide across phones other CMOS sensor-equipped devices. To broaden user base activate current users,...
Abstract Ionizing radiation (IR) has been extensively used for cancer therapy, but the radioresistance hinders and undermines radiotherapy efficacy in clinics greatly. Here, we reported that spliceosomal protein thioredoxin‐like 4B (TXNL4B) is highly expressed lung tissues from patients with radiotherapy. Lung cells TXNL4B knockdown illustrate increased sensitivity to IR. Mechanistically, interacts RNA processing factor 3 (PRP3) co‐localizes nucleus post‐IR. Nuclear localization of PRP3...
Purpose: The aim of our study was to investigate the amount initial DNA damage and cellular repair capacity human peripheral blood lymphocytes exposed therapeutic proton beam compare it X-rays. Materials methods: Lymphocytes from 10 healthy donors were irradiated in Spread Out Bragg Peak 60 MeV or, as a reference, 250 kV level assessed using alkaline version comet assay method. For both sources radiation, dose-DNA response (0-4 Gy) kinetics (0-120 min) estimated. observed then used calculate...
Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of along longitudinal axis is ~60 nm, while transverse ~20 nm. Raman, thermogravimetric analysis (TGA) differential scanning calorimetry (DCS) measurements showed, created...
To physically and cytogenetically screen medical personnel of Department Endocrinology Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland (DENM) who are occupationally exposed to 131I.The exposure was monitored by whole-body finger ring dosimeters. The thyroid iodine intake measured a spectrometer equipped with two semiconductor gamma radiation detectors. A cytokinesis-block micronucleus assay the premature chromosome condensation technique were used assess aberration score....
Abstract Herein, it is demonstrated that the toxic effect of gold nanoparticles (Au NPs) on three different cancer cell lines (U‐118 and LN‐299 glioblastoma HCT‐116 colon) depends their absorption dynamics by cells, related to shapes NPs. This hypothesis confirmed showing i) based refractive index (RI) values, typical for components nanoparticles, possible show accumulation locations latter ones inside outside cells. Moreover, ii) saturation accumulated Au NPs volume in cells nanoparticle...
Particle therapy is a growing cancer treatment modality worldwide. However, there still remains number of unanswered questions considering differences in the biological response between particles and photons. These questions, probing mechanisms general, necessitate experimental investigation. The "Infrastructure Proton International Research" (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on topic proton ion across Europe, facilitate...
The Cosmic Ray Extremely Distributed Observatory (CREDO) pursues a global research strategy dedicated to the search for correlated cosmic rays, so-called Ensembles (CRE). Its general approach CRE detection does not involve any priori considerations, and its encompasses both spatial temporal correlations, on different scales. Here we time clustering of ray events collected with small sea-level extensive air shower array at University Adelaide. consists seven one-square-metre scintillators...
Purpose of the study: One main difficulties in radiation dose assessment is cells inability to reach mitosis after exposure acute radiation. Premature chromosome condensation (PCC) has become an important method used biological dosimetry case high doses. Various ways induce PCC including mitotic fusion, chemical stimulation with calyculin A or okadaic acid give wide spectrum application. The goal this study was evaluate utility drug-induced scoring procedure by testing 2 experimental modes...
Purpose: The main aim of this study was to comparatively investigate the effects culturing methods on response human peripheral blood lymphocytes irradiation exposure.Materials and methods: Whole isolated were ex vivo exposed two radiation sources (60 MeV proton or 250 kV X-ray radiation) with different doses (0.3, 0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0 Gy), genotoxic markers subsequently assayed. observed compared as dose–response relationships using end points (CBMN PCC tests) biomarkers...
The Cosmic Ray Extremely Distributed Observatory (CREDO) is a newly formed, global collaboration dedicated to observing and studying cosmic rays (CR) ray ensembles (CRE): groups of minimum two CR with common primary interaction vertex or the same parent particle. CREDO program embraces testing known CRE scenarios, preparing observe unexpected physics, it also suitable for multi-messenger multi-mission applications. Perfectly matched capabilities, could be formed both within classical models...
The Cosmic Ray Extremely Distributed Observatory (CREDO) is a newly formed, global collaboration dedicated to observing and studying cosmic rays (CR) ray ensembles (CRE): groups of minimum two CR with common primary interaction vertex or the same parent particle. CREDO program embraces testing known CRE scenarios, preparing observe unexpected physics, it also suitable for multi-messenger multi-mission applications. Perfectly matched capabilities, could be formed both within classical models...