Congenital heart disease (CHD) is the most prevalent hereditary disorder, affecting approximately 1% of all live births. A reduction in morbidity and mortality has been achieved with advancements surgical intervention, yet challenges managing complications, extracardiac abnormalities, comorbidities still exist. To address these, a more comprehensive understanding genetic basis underlying CHD required to establish how certain variants are associated clinical outcomes. This will enable...

Abstract Mechanical load is one of the main determinants cardiac structure and function. studied in vitro using preparations together with loading protocols (e.g., auxotonic, isometric). However, such studies are often limited by reductionist models poorly simulated mechanical profiles. This hinders physiological relevance findings. Living myocardial slices have been used to study vitro. (LMS) 300‐μm‐thick intact organotypic obtained from explanted animal or human hearts. They preserved...

Abstract A retrospective cohort study of patients undergoing laparoscopic inguinal hernia repair compared short- and long-term outcomes between individuals with or without history previous abdominopelvic surgery, aiming to determine the feasibility totally extraperitoneal (TEP) within this population. All who underwent elective TEP by one consultant surgeon across three London hospitals from January 2017 May 2023 were retrospectively analysed assess perioperative outcomes. Two hundred...

Abstract Background Laparoscopic inguinal hernia repair is among the most frequently performed day-case operations. Ambulatory surgery centres alleviate pressures on acute provider hospitals and reduce patient anxiety nosocomial infection risk. However, concerns remain regarding safety of these facilities occurrence complications that may require inpatient stay. Method In 2020, a dedicated day surgical unit was established in London with no beds, requiring patients to return home their...

Abstract Background The use of robotics in hernia surgery is increasing. Continuous, real-time outcome analysis vital to inform and protect patients, enable cost-benefit decisions. Method Prospective data capture on patients undergoing robotic repair during one surgeon’s introduction into their high-volume practice. Results In the year 2023, 60 repairs were performed robotically: 29 ventral (transabdominal retromuscular umbilical prosthetic n = 12, parastomal Sugarbaker 5, transabdominal...

Abstract Background Use of robotics in hernia surgery is increasing. Comparison outcomes between traditional laparoscopic and novel robotic procedures vital to determine safety inform cost-benefit decisions. Method Prospective data capture on patients undergoing inguinal repair during one surgeon’s transition from an exclusively practice incorporating robotics. Results 28 transabdominal preperitoneal 79 totally extraperitoneal repairs were performed the calendar year 2023. In arm, median age...

Abstract Background A retrospective cohort study of patients undergoing laparoscopic inguinal hernia repair compared short- and long-term outcomes between individuals with or without history previous abdominopelvic (AP) surgery, to determine the feasibility totally extra-peritoneal (TEP) within this population. Method All who underwent elective TEP by one consultant surgeon across three London hospitals were retrospectively analysed assess perioperative outcomes. Results 308 operated on 2017...

Abstract Introduction There is ongoing debate over whether to fix asymptomatic contralateral inguinal hernias during repair of the presenting hernia. This study reviewed practice one high-volume hernia surgeon, comparing unilateral and bilateral laparoscopic repairs, establish if associated with an increased risk post-operative complications compared repair. Material & Methods All patients operated on within a 5-year period were audited subcategorised depending they underwent or Data was...

Abstract Introduction This study reviews the practice of a high-volume surgeon, comparing laparoscopic and open surgery for inguinal hernia. In suitable patients default was Totally Extra Peritoneal (TEP) approach. Materials & Methods Data from referred over 5 years with hernias collated prospectively analysed retrospectively. Short long-term outcomes repairs were compared. Results 205 underwent repair 288 (90.7% laparoscopic, 9.3% open). 83 bilateral (95.2% laparoscopic). 22 27...

Abstract Introduction This study aims to understand whether previous abdomino-pelvic (AP) surgery is a predictor of peri-operative complication in inguinal hernia and if there are discrepancies between laparoscopic or open repairs. Material & Methods All patients operated on within 5-year period were audited subcategorised based upon history AP surgery. Patients also categorised into groups. Data collected included rates, recurrence rates readmission 30 days. Results 205 underwent repair...