A5102000493- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Pelvic floor disorders treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Asthma and respiratory diseases
- Vascular Tumors and Angiosarcomas
- Reconstructive Surgery and Microvascular Techniques
- Social Media in Health Education
- Osteoarthritis Treatment and Mechanisms
- Hernia repair and management
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Hearing Loss and Rehabilitation
- Inhalation and Respiratory Drug Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health Literacy and Information Accessibility
Chelsea and Westminster Hospital NHS Foundation Trust
2020-2024
Imperial College London
2017-2021
Hammersmith Hospital
2021
Chelsea and Westminster Hospital
2017-2020
Royal Marsden Hospital
2017-2020
Addenbrooke's Hospital
2012
West Middlesex University Hospital
2012
A comparison between NCCN, ESMO and JSCCR Guidelines is presented, concerning the treatment of rectal cancer, with an analysis discussion their discrepancies. Differences indicate areas for research.Overall survival from cancer has almost doubled over last 20 years. Following recommendations in management guidelines plays some part this, but extent discrepancies them not been evaluated.National Comprehensive Cancer Network (NCCN, USA), European Society Medical Oncology (ESMO, Europe)...
Rationale: Airway wall inflammation, IL-4, and mucus hypersecretion are thought to be associated.Objectives: To quantify bronchial inflammatory cells in smokers with chronic bronchitis (CB) without airflow obstruction (AO), determining the expressing IL-4 IL-5 their association submucosal gland mucin.Methods: We applied immunohistochemistry identify, double-labeling colocalize, distinct resected bronchi from (1) 11 asymptomatic (AS), (2) CB, (3) 10 CB AO.Measurements Main Results: There were...
Adequate oncological outcomes have been demonstrated with rectal resection and handsewn coloanal anastomosis (CAA) in tumours close proximity to the internal anal sphincter. Our aim was assess functional differences between CAA ultralow stapled anastomosis. Participants were identified from a single-surgeon series. Included participants underwent anorectal physiology testing of sphincter function, addition completion several questionnaires: Wexner Incontinence Score (WIS); Birmingham Bowel,...
Earlier detection of colorectal cancer (CRC) results in improved survival. Existing non-invasive biomarkers have suboptimal accuracy. Neurotensin (NTS) is involved CRC carcinogenesis. This study evaluated the diagnostic potential plasma NTS for polyps and cancers. Participants were selected based on national referral guidelines. All subjects underwent colonoscopy. Average concentrations compared across different groups. Predictors detecting neoplasia identified. Receiver operator...
Colorectal cancer screening programs aim at early detection of to reduce incidence rates and mortality. The objective this study is identify the role neurotensin in endoscopic high-risk population for developing colorectal neoplasia. Blood samples from patients referred urgent colonoscopy investigate symptoms suspicious were collected. levels measured using enzyme-linked immunosorbent assay. Colonoscopy findings used as reference determining diagnostic accuracy blood neurotensin. comprised...
Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association CRC expression neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 NTSR3) clinical outcomes. Methods: A prospective cohort which quantifies protein NTS, NTSR1 NTSR3 human CRCs using immunohistochemistry. Expression levels were then compared with clinico-pathological outcome including histological grade, overall survival...
Prostatic abscess (PA) is a rare clinical entity due to variety of causative organisms including gram-negative bacilli, anaerobic and fungal agents. We report on 55-year-old, HIV+ patient presenting with 2-week history urethral discharge large PA. He was successfully treated combination radiological-guided transperineal drainage plus antibiotics. Treatment decisions in patients PA are multifactorial should be made all diagnostic information available from the most current modes medical...
Scalp pneumocoele is a rare complication of cochlear implantation surgery. We present the largest case series to date; consisting four cases over 8 years from one centre. The presentation, diagnosis, and management each are reviewed. Previously unreported complications pneumocoeles highlighted.Three our cases, two adults (aged 53 81 years) child 26 months), developed scalp within first 3 months implantation. Another 10) 7 after common diagnostic features include soft, non-tender, fluctuant...
Abstract Aim To demonstrate the quality improvement associated with implementation of a specialist family history bowel cancer service in secondary care. Method The following outcomes were assessed: (1) adherence to British Society Gastroenterology ( BSG ) guidelines for colonoscopic surveillance individuals colorectal (CRC); (2) revised Bethesda criteria identification CRC patients suspected Lynch syndrome; (3) inherited syndromes increased risk; and (4) adenoma detection rate. Data...
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare, often misdiagnosed malignancy of vascular origin. We describe case 36-year-old, who presented with burning sensation in his chest on exercise and was believed to have bilobar intrahepatic cholangiocarcinoma. After receiving chemotherapy partial response, the patient underwent staged resection modified associating liver partition portal vein ligation for hepatectomy (ALPPS) procedure-laparoscopic radiofrequency-assisted ALPPS...
Abstract A retrospective cohort study of patients undergoing laparoscopic inguinal hernia repair compared short- and long-term outcomes between individuals with or without history previous abdominopelvic surgery, aiming to determine the feasibility totally extraperitoneal (TEP) within this population. All who underwent elective TEP by one consultant surgeon across three London hospitals from January 2017 May 2023 were retrospectively analysed assess perioperative outcomes. Two hundred...
<h3>Introduction</h3> The British Society of Gastroenterology (BSG) updated guidelines for colonoscopic screening people with family history (FH) colorectal cancer (CRC) in 2010. In the UK, most patients anxious about their FH CRC are referred by primary care doctors to non-specialist hospitals. Previous studies indicate guideline adherence is poor significant clinical, medico-legal, and resource implications. <h3>Methods</h3> Our study analysed 2010 BSG a district general hospital...