A5102727098- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Advanced Synthetic Organic Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Metal complexes synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Nanomaterials for catalytic reactions
- Graphene research and applications
- Peptidase Inhibition and Analysis
- Vanadium and Halogenation Chemistry
- Chemistry and Chemical Engineering
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Catalytic Processes in Materials Science
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Characterization of Pyrroles
- Carbon dioxide utilization in catalysis
Peking University
2015-2024
Beijing National Laboratory for Molecular Sciences
2024
Yuncheng University
2020
University of Science and Technology of China
2018
Central South University
2014-2015
Anhui University
2012
An efficient Mn-catalyzed aerobic oxidative hydroxyazidation of olefins for synthesis β-azido alcohols has been developed. The generation azido radical employing air as the terminal oxidant is disclosed key process this transformation. reaction appreciated by its broad substrate scope, inexpensive Mn-catalyst, high efficiency, easy operation under air, and mild conditions at room temperature. This chemistry provides a novel approach to value-added alcohols, which are useful precursors...
Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp
The catalytic decarboxylative nitrogenation of aliphatic carboxylic acids for the synthesis alkyl azides is reported. A series tertiary, secondary, and primary organoazides were prepared from easily available by using K2S2O8 as oxidant PhSO2N3 nitrogen source. EPR experiment sufficiently proved that an radical process was generated in process, DFT calculations further supported SET followed a stepwise SH2 reaction to afford azide product.
Abstract A novel and efficient Fe‐catalyzed direct C−H amination (NH 2 ) of arenes is reported using a new redox‐active aminating reagent. The reaction simple, can be performed under air, mild, redox‐neutral conditions. This protocol has broad substrate scope could used in the late‐stage modification bioactive compounds. Mechanistic studies demonstrate that radical pathway involved this transformation.
Abstract The first example of Pd II ‐catalyzed enantioselective C−H olefination with non‐chiral or racemic sulfoxides as directing groups was developed. A variety chiral diaryl were synthesized high enantioselectivity (up to 99 %) through both desymmetrization and parallel kinetic resolution (PKR). This is the report C(sp 2 )−H functionalization PKR, it represents a novel strategy construct sulfur centers.
Oximes and oxime ethers are privileged building blocks can be conveniently converted to ketones, amines, hydroxylamines, nitriles. We describe the catalytic decarboxylation of aliphatic carboxylic acids ethers. With AgNO3 as catalyst, valuable bearing various substituents could easily obtained. The broad substrate scope, easy accessibility acids, mild reaction conditions make this strategy immediately applicable synthesis, late-stage functionalization, modification biologically active...
Control of selectivity is one the central topics in organic chemistry. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot attention, compared to selective C-H activation, radical O-H activation remains less explored. Herein, we report novel strategy diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO an essential reagent enables regioselective transformation diols. Mechanistic studies indicated existence alkoxyl...
Abstract Aerobic epoxidation of tertiary allylic alcohols remains a significant challenge. Reported here is an efficient and highly chemoselective copper‐catalyzed semipinacol rearrangement reaction with molecular oxygen. The solvent 1,4‐dioxane activates dioxygen, thereby precluding the addition sacrificial reductant.
Abstract A novel activation of acetonitrile for the construction cyclobutenones by [2+2] cyclization was developed. Acetonitrile is utilized first time as two‐carbon (C2) building block. The present protocol successfully inhibits competitive cycloaddition with C≡N bond acetonitrile, but enables in situ formation an unsaturated carbon–carbon and subsequent a C2 unit. This chemistry features simple reaction conditions, high chemoselectivities, wide substrate scope, offers new practical...
Abstract The first example of Pd II ‐catalyzed enantioselective C−H olefination with non‐chiral or racemic sulfoxides as directing groups was developed. A variety chiral diaryl were synthesized high enantioselectivity (up to 99 %) through both desymmetrization and parallel kinetic resolution (PKR). This is the report C(sp 2 )−H functionalization PKR, it represents a novel strategy construct sulfur centers.
A Pd catalyst on monolithic cordierite with graphene coating was prepared assistance from poly(diallyldimethylammonium chloride) (PDDA). The obtained exhibits both high stability and activity in the liquid hydrogenation reaction of styrene due to improved interaction between enhanced dispersion particles.
Abstract Control of selectivity is one the central topics in organic chemistry. Although unprecedented alkoxyl‐radical‐induced transformations have drawn a lot attention, compared to selective C−H activation, radical O−H activation remains less explored. Herein, we report novel strategy diols by combining spatial effects with proton‐coupled electron transfer (PCET). It was found that DMSO an essential reagent enables regioselective transformation diols. Mechanistic studies indicated...
Abstract A novel activation of acetonitrile for the construction cyclobutenones by [2+2] cyclization was developed. Acetonitrile is utilized first time as two‐carbon (C2) building block. The present protocol successfully inhibits competitive cycloaddition with C≡N bond acetonitrile, but enables in situ formation an unsaturated carbon–carbon and subsequent a C2 unit. This chemistry features simple reaction conditions, high chemoselectivities, wide substrate scope, offers new practical...
Abstract Aerobic epoxidation of tertiary allylic alcohols remains a significant challenge. Reported here is an efficient and highly chemoselective copper‐catalyzed semipinacol rearrangement reaction with molecular oxygen. The solvent 1,4‐dioxane activates dioxygen, thereby precluding the addition sacrificial reductant.
The regiodivergent synthesis of exomethylene-bearing azatricyclic products was achieved via aza-[4 + 2] annulations cyclic imines with a single C4 synthon, the α-vinyl MBH adduct.
Comprehensive Summary The advancement of bioorthogonal cleavage reactions (BCRs) has expanded the scope chemistry toolkit, leading to a diverse array innovative biological applications. These include but are not limited precise spatial and temporal activation intracellular probes, prodrugs, proteins, glycans, nucleic acids. Herein, we summarize recent efforts by our group develop BCRs for manipulating functional molecules in living species meet various needs, along with future perspectives...
In the triaryl-amine group of title compound, C(26)H(20)N(2)O(2), N atom adopts an approximately trigonal-planar geometry, lying 0.046 (5) Å from plane P defined by its three neighbouring C atoms; benzene and two terminal phenyl rings are twisted 37.4 (1), 31.4 (1) 47.8 (1)°, respectively P. trans-stilbene fragment, form a dihedral angle 31.3 (1)°. crystal, weak inter-molecular C-H⋯O inter-actions link mol-ecules into ribbons in [100].
Abstract Azido radical generation employing air as the terminal oxidant is disclosed key process for this transformation.
Abstract This novel decarboxylative azidation method is successfully applied to a number of tertiary, secondary, and primary aliphatic carboxylic acids.