A5100388755- Endoplasmic Reticulum Stress and Disease
- Microtubule and mitosis dynamics
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Caveolin-1 and cellular processes
- Lower Extremity Biomechanics and Pathologies
- Horticultural and Viticultural Research
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- DNA Repair Mechanisms
- Plant Pathogens and Fungal Diseases
- Tendon Structure and Treatment
- RNA Research and Splicing
- Cancer-related gene regulation
- Fungal Plant Pathogen Control
- RNA and protein synthesis mechanisms
- Cellular transport and secretion
- Cellular Mechanics and Interactions
Dalian Medical University
2024-2025
Northwest University
2024
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
Second Affiliated Hospital of Nanjing Medical University
2021-2022
Hubei University of Science and Technology
2022
University of Utah
2018
Tsinghua University
2009
The medial patellofemoral ligament (MPFL) is the most important passive restraint of patella and provides approximately 53% to 80% soft-tissue restraints, although its relationship parapatellar structures still not completely understood. Twenty-six formalin-fixed knees (13 for P45 plastination, 10 dissection, 3 histology) were obtained from cadavers donated Department Anatomy at Dalian Medical University. mean age donors was 78.1 years (range, 52 95 years). These specimens 4 women men....
Regulated intramembrane proteolysis (RIP) by the Site-2 protease (S2P) results in release of a transmembrane signaling protein. Curiously, however, S2P cleavage must be preceded action Site-1 (S1P). To decipher underlying mechanism, we reconstituted sequential, vitro cleavages Escherichia coli protein RseA DegS (S1P) and RseP (S2P). After cleavage, newly exposed carboxyl-terminal residue Val-148 plays an essential role for its mutation to charged or dissimilar amino acids crippled cleavage....
Sec23 homolog A (SEC23A), a core component of coat protein complex II (COPII), has been reported to be involved in several cancers. However, the role SEC23A gastric cancer remains unclear.The expression was analyzed by using qRT-PCR, western blotting and IHC staining. The ER stress resistance explored functional experiments vitro vivo. occupation STAT3 on promoter region verified luciferase reporter plasmids CHIP assay. interaction between ANXA2 identified Co-IP mass spectrometry analysis.We...
Abstract The increasing incidence of hepatocellular carcinoma (HCC) is great concern globally, but the molecular pathogenesis these tumors remains unclear. Sorafenib a first-line drug for treatment advanced HCC. However, efficacy sorafenib in improving patient survival limited, and most patients inevitably develop resistance to this drug. Recent studies have demonstrated that activation IRE1α–XBP1s pathway might play protective role response contribute malignancy Here, we found RCN1, an...
Gastric cancer (GC) is one of the most common human malignancies worldwide, but molecular mechanism GC has not been fully elucidated. Tetraspanin 31 (TSPAN31) rarely studied in malignant tumors. This study aimed to investigate effects TSPAN31 on GC. We analyzed tissues through high-throughput sequencing technology and chose with high expression. The expression was bioinformatics website qRT-PCR. protein level determined by western blot immunochemistry. proliferation, migration, apoptosis...
To develop a deep learning model for synthesizing the first phases of dynamic (FP-Dyn) sequences to supplement lack information in unenhanced breast MRI examinations.In total, 97 patients with images were collected as training set (n = 45), validation 31), and test 21), respectively. An enhance border lifelike synthesize (EDLS) was developed used FP-Dyn from T1WI set. The peak signal-to-noise ratio (PSNR), structural similarity (SSIM), mean square error (MSE) absolute (MAE) synthesized...
There is increasing interest in utilizing AI-generated content for gadolinium-free contrast-enhanced breast MRI. To develop a generative model MRI and evaluate the diagnostic utility of generated scans. Retrospective. Two hundred seventy-six women with 304 examinations (49 ± 13 years, 243/61 training/testing). ZOOMit diffusion-weighted imaging (DWI), T1-weighted volumetric interpolated breath-hold examination (T1W VIBE), axial T2 3D SPACE at 3.0 T. A was developed to generate scans using...
Abstract The myodural bridge (MDB) is a fibrous structure that connects the suboccipital musculature to cervical spinal dura mater (SDM) via atlanto-occipital and atlanto-axial interspaces. Muscles, ligaments, MDB fibers integrated functional unit known as complex (MDBC). an evolutionarily conserved physiological considered dynamic source of cerebrospinal fluid circulation. Integrin α7 (ITGA7) plays crucial role in transmitting both longitudinal lateral forces generated by muscle...