A5039363904- Cancer-related molecular mechanisms research
- Ferroelectric and Piezoelectric Materials
- RNA modifications and cancer
- Microwave Dielectric Ceramics Synthesis
- Multiferroics and related materials
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acoustic Wave Resonator Technologies
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Geochemistry and Elemental Analysis
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- Macrophage Migration Inhibitory Factor
- Lipid metabolism and disorders
- Phosphorus and nutrient management
- Caveolin-1 and cellular processes
- Metastasis and carcinoma case studies
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2022-2024
Hubei University
2018-2021
Abstract SULF1 has been implicated in a number of malignancies. The function gastric cancer is disputed. objective this study was to examine the role and underlying molecular mechanisms context cancer. We found that expression increased cancer, especially cancer-associated fibroblasts. overexpression be significantly correlated with unfavorable prognosis among individuals diagnosed Functionally, fibroblasts-derived served as oncogenic molecule which facilitated cells metastasis CDDP...
Sec23 homolog A (SEC23A), a core component of coat protein complex II (COPII), has been reported to be involved in several cancers. However, the role SEC23A gastric cancer remains unclear.The expression was analyzed by using qRT-PCR, western blotting and IHC staining. The ER stress resistance explored functional experiments vitro vivo. occupation STAT3 on promoter region verified luciferase reporter plasmids CHIP assay. interaction between ANXA2 identified Co-IP mass spectrometry analysis.We...
Gastric cancer (GC) is a common digestive malignancy that causes numerous cancer-related deaths. Long noncoding RNAs (lncRNAs) play crucial role in the development of various tumors, including GC. In this study, we revealed ELFN1-AS1, lncRNA with aberrantly high expression, contributes to proliferation and metastasis Mechanically, ELFN1-AS1 plays an oncogenic by binding protein kinase domain thousand one amino acid (TAOK1), tumor suppressor GC, disrupting TAOK1-STK3 interaction, leading...
Abstract Background The connection between obesity, lipid accumulation, and lymph node metastasis (LNM) in gastric cancer (GC) is unclear. Methods association of body mass index (BMI) serum levels with LNM was measured by calculating the odds ratio (OR) 95% confidence interval (CI) 1,058 eligible GC patients a mean age 61.4 years. Meanwhile, differentially expressed genes (DEGs) were identified metastasis-positive (N +) -negative (N0) groups using public RNA-seq data. Neutral lipids human...
Abstract Na 0.5 Bi 4.5‐ x Ce Ti 4 O 15 ( = 0, 0.02, 0.04, 0.06, 0.08, 0.10) lead‐free piezoelectric ceramics with high Curie temperatures are fabricated using the conventional solid‐phase method. The effects of content on phase structures, morphologies, and electrical properties systematically investigated. appropriate increases b/a c/a induces distortion crystal structure. increased leads to a transverse asymmetry ceramics, which facilitates dipole flipping, thus enhancing d 33 20 pC/N)....
Gastric cancer (GC) is a global health problem and further studies of its molecular mechanisms are needed to identify effective therapeutic targets. Although some long noncoding RNAs (lncRNAs) have been found be involved in the progression GC, many GC-related lncRNAs remain unclear. In this study, series vivo vitro assays were performed study relationship between FAM225A which showed that levels correlated with poor prognosis GC. Higher expression tended more profound lymphatic metastasis...
Recent studies have identified cuproptosis, a new mechanism of regulating cell death. Accumulating evidence suggests that copper homeostasis is associated with tumorigenesis and tumor progression, however, the clinical significance cuproptosis in gastric cancer (GC) unclear. In this study, we obtained 26 prognostic cuproptosis-related lncRNAs (CRLs) based on 19 genes (CRGs) via Pearson correlation analysis, differential expression univariate Cox analysis. A risk model 10 CRLs was established...
Background. Although tumor size is regarded as the “T” stage of tumor-node-metastasis (TNM) staging system for many solid tumors, its prognostic impact in gastric cancer remains uncertain and conflicting. Methods. We enrolled 6960 eligible patients from Surveillance, Epidemiology, End Results (SEER) database. The X-tile program was used to select best cut-off value size. Then, Kaplan–Meier method Cox proportional hazards model were applied examine efficacy on prediction overall survival (OS)...
Abstract Background Great progress has been made in studying the function of long non‐coding RNA (lncRNA) various tumors, including gastric cancer (GC). However, there are still numerous lncRNAs that have not yet studied and explored for their roles GC, important functions need to be further revealed. Methods Through analyzing The Cancer Genome Atlas (TCGA) database combined with bioinformatics survival tools, a novel GC‐related lncRNA LGALS8‐AS1 was identified. A quantitative real‐time...
ABSTRACTMounting evidence indicates the potential involvement of ATP-citrate lyase (ACLY) in modulation various cancer types. Nevertheless, precise biological significance ACLY gastric (GC) remains elusive. This study sought to elucidate function and uncover its influence on peritoneal metastasis GC. The expression was assessed using both real-time quantitative PCR western blot techniques. To investigate impact proliferation cells, colony formation 5-ethynyl-2'-deoxyuridine (EdU) assays were...
As one of the representatives lead-free NBT ceramics, Na[Formula: see text]Bi[Formula: text]Ti 4 O[Formula: text] has still attracted much attention due to its excellent dielectric properties and become focus research. However, piezoelectric are far from satisfactory. In order improve text], text]Ti[Formula: text]Mg x O y –BaTiO 3 (NBTM–BT) composite ceramics were synthesized by a conventional mixed oxide route sintered at 1040 ∘ C through two-step method. We optimized electrical NBTM–BT...
Abstract Electrocaloric effects due to entropy change and dipole coupling upon electric field in second‐order phase transition (tetragonal‐cubic) ferroelectrics are investigated by a three‐dimensional Devonshire's theory statistic method. In diabatic condition, increase vibration heat the ferroelectric is decreases polarization configuration of reorientation specific directions. Coupling effect originated from dipoles accompany with hysteresis loop happens nearest neighbor parallel...