A5093320454- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Modular Robots and Swarm Intelligence
- Pluripotent Stem Cells Research
- Evolutionary Algorithms and Applications
- RNA Research and Splicing
École Polytechnique Fédérale de Lausanne
2023-2024
ABSTRACT Gastruloids have recently emerged as an efficient four-dimensional model for studying some aspects of post-implantation embryonic patterning. They undergo gastrulation-like processes leading to the self-organization into highly reproducible biological objects. Here, we sought uncover molecular and cellular mechanism underlying this remarkable property. We report that competence is associated with a cell-specific coordination Cadherin switch. find N-Cadherin hinders gastruloids...
Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-implantation mammalian development, provide powerful platform to address this question. Here, we show that physical parameters, particularly system size, critically influence timing outcomes processes. Larger gastruloids exhibit delayed symmetry breaking, increased multipolarity, prolonged axial...