A5102816658- Mast cells and histamine
- melanin and skin pigmentation
- Chronic Lymphocytic Leukemia Research
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Phytochemical compounds biological activities
- Platelet Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Antimicrobial Peptides and Activities
- Atherosclerosis and Cardiovascular Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Chinese Academy of Medical Sciences Dermatology Hospital
2021
Feed Research Institute
2017
China Agricultural University
2017
Two studies were performed to assess the efficacy of Lactobacillus plantarum B1 in prevention pathogenic Escherichia coli K88 gastrointestinal infection broilers. In an vitro study, L. showed resistance acid and bile inhibited growth E. K88. Additionally, exhibited high ability adhere broiler embryo ileal epithelium. animal trial, 240 broilers at 1 d age randomly assigned one 4 treatment arms: negative control (NC) fed a basal diet not challenged; positive (PC) challenged with K88; (LP)...
Vitiligo is an acquired depigmentation skin disease, which affects average of 1% the world's population. The purpose this study to identify key genes and pathways responsible for vitiligo find new therapeutic targets.The datasets GSE65127, GSE53146, GSE75819 were downloaded from Gene Expression Omnibus (GEO) database. R language was used differentially expressed (DEGs) between lesional non-lesional skin. Next, obtained by Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment...
Vitiligo is a skin disease characterized by selective loss of melanocytes, which seriously affects the appearance and causes great psychological stress to patients. In this study, we performed comprehensive analysis two vitiligo microarray datasets from GEO database using bioinformatics tools identify 297 up-regulated mRNAs 186 down-regulated mRNAs, revealing important roles for pathways related melanin synthesis, tyrosine metabolism, inflammatory factors, such as "PPAR signaling pathway",...
Herein we describe the medicinal chemistry efforts that led to discovery of clinical-staged Syk inhibitor sovleplenib (41) via a structure–activity relationship investigation and pharmacokinetics (PK) optimization pyrido[3,4-b]pyrazine scaffold. Sovleplenib is potent selective with favorable preclinical PK profiles robust anti-inflammation efficacy in collagen-induced arthritis model. now being developed for treating autoimmune diseases such as immune thrombocytopenic purpura warm antibody...