A5101888057- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Ion Transport and Channel Regulation
- Advanced Measurement and Metrology Techniques
- Advanced Optical Sensing Technologies
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Optical measurement and interference techniques
- Inflammatory mediators and NSAID effects
- Microbial Metabolic Engineering and Bioproduction
- Photoreceptor and optogenetics research
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Hemoglobin structure and function
- Fermentation and Sensory Analysis
- Neuroscience and Neuropharmacology Research
- Advanced Fiber Optic Sensors
- Gut microbiota and health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Remote Sensing and LiDAR Applications
- Laser Design and Applications
- Advanced Measurement and Detection Methods
East China University of Science and Technology
2024-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Yantai University
2024
Harbin Engineering University
2024
Jiangnan University
2023-2024
Chongqing University
2022-2024
Shanghai Ocean University
2023-2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Huazhong Agricultural University
2023-2024
Recent studies have shown that angiotensin-(1-7) (Ang-[1-7]), which is generated endogenously from both Ang I and II, a bioactive component of the renin-angiotensin system may play an important role in regulation blood pressure. However, little known about its regulating reactivity afferent arteriole or mechanism(s) involved. We hypothesized Ang-(1-7), acting on specific receptors, participates control tone. first examined direct effect Ang-(1-7) rabbit arterioles microperfused vitro, we...
Abstract β‐Phenylethanol (2‐PE), as an important flavor component in wine, is widely used the fields of chemistry and food health. 2‐PE can be sustainably produced through Saccharomyces cerevisiae . Although significant progress has been made obtaining high‐yield strains, well improving synthesis pathways 2‐PE, there still lies a gap between these two to unpin. In this study, macroscopic metabolic characteristics low‐yield strains were systematically compared analyzed. The results indicated...
The aromatic compound β-phenylethanol (2-PE) is inherently toxic and can inhibit cell activity in Saccharomyces cerevisiae, making it highly challenging to enhance strain tolerance through rational design due the lack of reliable connections between phenotype genetic loci. This study employed adaptive laboratory evolution strategy investigate characteristics S. cerevisiae S288C under inhibitory concentrations 2-PE. tolerant mutant SEC4.0 was characterized comprehensive analysis whole genome...
Spontaneously hypertensive rats (SHRs) have normal glomerular capillary pressure even though renal perfusion is higher, suggesting that preglomerular vessels exhibit abnormally high resistance. This may be due to increased superoxide (O(2)(-)) production, which contributes the vasoconstriction in hypertension. We tested hypothesis myogenic response of afferent arteriole (Af-Art) exaggerated SHRs because levels reactive oxygen species (ROS). Single Af-Arts were microdissected from kidneys and...
Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis tumour management. However, its association with adrenocortical carcinoma (ACC) is rarely discussed.Differential analysis, Cox regression survival analysis were used to screen hub TCGA GTEx databases sets. Then, we performed an between clinically relevant factors ACC patients. Univariate multivariate analyses evaluate prognostic value of factors. Weighted...
Utilizing the periodicity of rotating machinery, dynamic clearance measurement can be achieved with a single swept light source without any additional auxiliary devices, which has advantages simplicity and reliability. However, there is shortcoming that previous algorithm not fast enough to achieve real-time when machinery rotates at high speed. Aiming this shortcoming, utilizing correlation between mimic signal signal, combined information for multiple periods, algorithms corrected model...
The macula densa detects changes in NaCl concentration tubular fluid and transmits a feedback signal, known as tubuloglomerular (TGF), which helps to control glomerular afferent arteriole resistance. We other investigators have reported that synthesis of NO the inhibits TGF. can be scavenged by superoxide (O − 2 ) form peroxynitrite, effectively reducing bioavailability NO; there is growing evidence O regulates vascular tone kidney. hypothesized produced enhances TGF this effect acts only an...
Superoxide (O(2)(-)) enhances tubuloglomerular feedback by scavenging nitric oxide at the macula densa. However, singling pathway of O(2)(-) production in densa is not known. We hypothesized that increase tubular NaCl concentration initiates induces via NAD(P)H oxidase, which activated depolarization. isolated and microperfused thick ascending limb loop Henle attached rabbits. A fluorescent dye, dihydroethidium, was used to detect When luminal switched from 10 80 mM, a situation initiating...
Increasing Na delivery to epithelial channels (ENaC) in the connecting tubule (CNT) dilates afferent arteriole (Af-Art), a process we call glomerular feedback (CTGF). We hypothesize that aldosterone sensitizes CTGF via nongenomic mechanism stimulates CNT ENaC receptor GPR30. Rabbit Af-Arts and their adherent CNTs were microdissected simultaneously perfused. Two consecutive curves elicited by increasing luminal NaCl CNT. During control period, concentration of half-maximal response (EC50) was...
In recent years, unmanned aerial vehicle (UAV) remote sensing systems have advanced rapidly, enabling the effective assessment of crop growth through processing and integration multimodal data from diverse sensors mounted on UAVs. UAV-derived encompass both multi-source non-remote data. This study employs Image Guided Filtering Fusion (GFF) to obtain high-resolution multispectral images (HR-MSs) selects three vegetation indices (VIs) based correlation analysis feature reduction in HR-MS for...
In the renal cortex, connecting tubule (CNT) returns to glomerular hilum and contacts afferent arteriole (Af-Art). Increasing Na delivery CNT dilates Af-Art by activating epithelial channels, a process that we call feedback (CTGF). However, mediator(s) of CTGF are unknown. We tested hypothesis reabsorption induces release arachidonic acid metabolites diffuse dilate Af-Art. Microdissected rabbit Af-Arts adherent CNTs were simultaneously microperfused. was measured as increase in diameter...
Connecting tubule glomerular feedback (CTGF) is a mechanism in which Na reabsorption the connecting (CNT) causes afferent arteriole (Af-Art) dilation. CTGF mediated by eicosanoids, including prostaglandins and epoxyeicosatrienoic acids; however, their exact nature source remain unknown. We hypothesized that during CTGF, CNT releases prostaglandin E2, binds its type 4 receptor (EP4) dilates Af-Art. Rabbit Af-Arts with adherent intact were microdissected, perfused, preconstricted...