A5073718373- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Metabolomics and Mass Spectrometry Studies
- Phytochemical compounds biological activities
- Medicinal Plant Pharmacodynamics Research
- Traditional and Medicinal Uses of Annonaceae
- Traditional Chinese Medicine Analysis
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Respiratory Support and Mechanisms
- Botanical Studies and Applications
- Food Quality and Safety Studies
- Cardiovascular Disease and Adiposity
- Phytoestrogen effects and research
- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Tea Polyphenols and Effects
- Cancer-related molecular mechanisms research
- Medicinal Plants and Bioactive Compounds
- Hormonal Regulation and Hypertension
- Redox biology and oxidative stress
- thermodynamics and calorimetric analyses
- Cholesterol and Lipid Metabolism
Institute of Biomedical Science
2025
Shandong Normal University
2025
Nanjing University of Chinese Medicine
2020-2024
Kaiping Central Hospital
2014
Atherosclerotic plaque calcification is an oxidative-stress-dependent process involved in the onset of disruption and subsequent atherothrombotic events. Excessive reactive oxygen species (ROS) production determines structural modification protein cysteine sulfhydryl (Cys-SH), leading to alteration functions redox signaling outputs. Although these redox-centered pathways have been found play important roles calcification, extent Cys-SH modifications regulatory regions specific proteins...
The rhizome of Atractylodes lancea (Thunb.) DC. (AL), called Maocangzhu in Chinese, is a geoherbalism medical herb Jiangsu Province that often used the prescription traditional Chinese medicine (TCM), such as for treatment COVID-19. landform and climatic environment each province varies greatly from south to north, which has an important influence on chemical constituents AL. However, there lack research significance its geoherbalism, especially water-soluble parts other than volatile oil....
In this study, a fingerprint-activity relationship modeling between chemical fingerprints and antirheumatic activity was established, multivariate statistical analysis used to evaluate the quality of Taxilli Herba (TH) from different hosts. Characteristic 20 batches TH samples were generated by high-performance liquid chromatography coupled with triple quadrupole-time flight tandem mass spectrometry (HPLC-Triple TOF-MS/MS), similarity calculated based on thirteen common characteristic peaks...
Lysimachiae Herba (LH), called Jinqiancao in Chinese, is an authentic medical herb Sichuan Province often used the prescription of traditional Chinese medicine (TCM). However, recent years, there has been a lack comprehensive research on its chemical components. In addition, landform varies greatly from east to west and terrain complex diverse, which important influence constituents LH. this study, ultrafast liquid chromatography coupled with triple-quadrupole time-of-flight tandem mass...
Tetrastigmae Radix, also known as Sanyeqing (SYQ) in Chinese, is an important traditional Chinese medicine with a long history. Tetrastigma hemsleyanum Diels et Gilg mainly grows the south of Yangtze River and widely distributed. The content bioactive constituents SYQ varies greatly different habitats, there are obvious differences between southwestern (WS) southeastern (ES). To distinguish evaluate quality ES WS, analytical method based on ultrafast performance liquid chromatography coupled...
A method based on ultra-high performance liquid chromatography coupled with triple quadrupole linear ion trap-tandem mass spectrometry(UHPLC-QTRAP-MS/MS) was developed for the simultaneous determination of 41 bioactive constituents flavonoids, organic acids, nucleosides, and amino acids in Lysimachiae Herba. The content multiple compared among samples from different habitats. chromatographic separation performed a Waters XBridge®C_(18) column(4.6 mm×100 mm, 3.5 μm) at 30 ℃. gradient elution...
Tetrastigmae Radix (TR) is the tuber of Tetrastigma hemsleyanum Diels et Gilg, which frequently used in Chinese folklore medicine as a therapeutic food. TR becoming more popular because its superior pharmacological properties, including anticancer and antioxidant properties. However, wild-TR (WTR) resources are few market, cultivated-TR (CTR) progressively replacing WTR primary source commercial herbs. Furthermore, diverse growing environment, CTR may differ from terms characteristics,...
Epimedii Folium (EF) is a commonly used traditional Chinese drug that includes many species. In Pharmacopoeia (2020 edition), EF Epimedium brevicornu Maxim, E. Sagittatum (Sieb. et Zucc) pubescens koreanum Nakai, and Wushanense T.S. Ying. It has been reported the active constituents in are different, resulting uneven quality of commercial medicinal materials. To explore specific differences make comprehensive evaluation EF, we established an analytical method to simultaneously detect 45...
A comprehensive analytical method based on ultra-fast liquid chromatography coupled with triple quadrupole/linear ion trap tandem mass spectrometry(UFLC-QTRAP-MS/MS) was established for simultaneous determination of the content 45 bioactive constituents including flavonoids, alkaloids, amino acids, phenolic and nucleosides in Epimedium brevicornum. The multiple leaves, petioles, stems rhizomes E. brevicornum were analyzed. gradient elution performed at 30 ℃ an XBridge~® C_(18) column(4.6...
Taxilli Herba (TH) is famous for its semi-parasitic feature, with hundreds of host species. The molecular mechanisms governing the accumulation bioactive constituents in TH from different hosts have yet to be completely understood. purpose this study was investigate differences synthesis and Morus alba L. Liquidambar formosana Hance. proteome two were compared, proteins identified using tandem mass tag (TMT) technology. Sixteen quantitatively determined analyzed conjunction results...
Taxilli Herba (TH) is a semi-parasitic herb and the host key factor affecting its quality. Flavonoids are main bioactive constituents in TH. However, studies on difference accumulation of flavonoids TH from different hosts vacant. In this study, integrated transcriptomic metabolomic analyses were performed Morus alba L. (SS) Liquidambar formosana Hance (FXS) to investigate relationship between regulation gene expression constituents. The results showed that total 3319 differentially...
The medicinal halophyte plant Apocynum venetum L. can tolerate high salt levels in the soil, which significantly affects its growth and development. To study molecular mechanisms underlying environmental adaptations, omics tools were employed. plants subjected to varying of stress. corresponding RNA Apocyni Veneti Folium (AVF), leaf L., was sequenced using a de novo approach. Functional annotation expression analysis utilised identify differentially expressed transcription factors (TFs)....
Abstract Background: Taxilli Herba (TH) is a semi-parasitic therapeutic herb and the host plant key factor affecting its quality. Morus alba L. (SS) Liquidambar formosana Hance (FXS) are two most frequent hosts. The purpose of this study was to elucidate underlying molecular mechanism causing variation in accumulation bioactive constituents TH from SS FXS. Results: In paper, 3319 differentially expressed genes (DEGs) comprising transcription families AP2/ERF MYB super_family were identified....