A5112427775- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Alcohol Consumption and Health Effects
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Chromosomal and Genetic Variations
- Biosensors and Analytical Detection
- Genetics and Neurodevelopmental Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic Neurodegenerative Diseases
- Homelessness and Social Issues
- Science, Research, and Medicine
- Cancer-related gene regulation
- Viral Infections and Vectors
- Gene expression and cancer classification
- Plant Virus Research Studies
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Substance Abuse Treatment and Outcomes
- Digestive system and related health
- Glioma Diagnosis and Treatment
Indiana State University
2025
Cancer Research Center
2025
Tempus Labs (United States)
2020-2022
University of British Columbia
2015-2019
British Columbia Children's Hospital
2018
Child and Family Research Institute
2015-2016
Bangladesh Council of Scientific and Industrial Research
2013
The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study tissue-specific DNA methylation (DNAm) variation human populations. To date, characterizations inter-individual DNAm variability and concordance across have been largely performed adult therefore are limited their relevance to profiles from pediatric samples. Given that patterns early life undergo rapid changes linked a wide range health outcomes environmental exposures,...
Despite extensive progress in Huntington's disease (HD) research, very little is known about the association of epigenetic variation and HD pathogenesis human brain tissues. Moreover, its contribution to tissue-specific transcriptional regulation huntingtin gene (HTT), which HTT expression levels are highest testes, currently unknown. To investigate role DNA methylation HTT, we utilized Illumina HumanMethylation450K BeadChip array measure a cohort age-matched control cortex liver In samples,...
Glioblastoma multiforme (GBM) is the most deadly brain tumor, and currently lacks effective treatment options. Brain tumor-initiating cells (BTICs) orthotopic xenografts are widely used in investigating GBM biology new therapies for this aggressive disease. However, genomic characteristics molecular resemblance of these models to tumors remain undetermined. We massively parallel sequencing technology decode genomes transcriptomes BTICs their matched order delineate potential impacts distinct...
ABSTRACT The precise regulation of transcription required for embryonic development is partially controlled by the actions Trithorax group (TrxG) and Polycomb (PcG) proteins. genes trithorax (trx), trithorax-related (trr), SET domain containing 1 (Set1) encode COMPASS-like histone methyltransferases, a subgroup TrxG proteins that impart H3K4 methylation modifications onto chromatin in order to activate maintain transcription. In this study, we identify role these heart fruit fly Drosophila...
Abstract Background: PRAME (Preferentially Expressed Antigen in Melanoma) is an intracellular cancer-testis antigen over-expressed across solid tumor types. Elevated expression associated with poor prognosis, particularly lung cancer. Further, its selective cells and ability to induce robust T-cell-mediated immune responses make it a promising pan-cancer immunotherapy target. This study investigates the influence of histological subtypes on impact outcome first line (1L) cancer patients....
Abstract Several studies have shown an association of alcohol dependence with DNA methylation (DNAm), suggesting that environmentally-induced changes on epigenomic variation may play important role in dependence. In the present study, we analysed genome-wide DNAm profiles purified CD3 + T-cells from pre- and post-treatment dependent patients, as well closely matched healthy controls. We identified 59 differentially methylated CpG sites comparing patients prior to treatment controls were able...
3077 Background: While targeted DNA-seq can detect clinically actionable fusions in tumor tissue samples, technical and analytical challenges may give rise to false negatives. RNA-based, whole-exome sequencing provides a complementary method for fusion detection, improve the identification of variants. In this study, we quantify benefit using large, real-world clinical dataset assess detected from RNA conjunction with DNA profiling. Methods: Using Tempus Research Database, retrospectively...
Abstract Gene fusions can serve as key drivers in the development of various cancers and represent important therapeutic targets diagnostic biomarkers. Due to high detection candidate from RNA-sequencing data, there is a recognized need build tools that will make reasonable automated predictions identify clinically or biologically relevant fusion events tumor sample. We developed computational pipeline which scores prioritizes all detected transcripts within sample determine are likely...
Background: Asthma is the most prevalent chronic disease among children and affects 235 million people worldwide [1].Although incidence of asthma in South America highest worldwide, underlying causes phenotypes are poorly defined may differ to developed countries.Recent evidence mice [2] human [3] has identified a 'critical window' early life where effects gut microbial changes (dysbiosis) influential immune development experimental asthma.Given differences microbiota between North American...