A5102955399- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Cardiovascular Health and Disease Prevention
- Microbial Metabolites in Food Biotechnology
- Genetic Mapping and Diversity in Plants and Animals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Digestive system and related health
- Neurological and metabolic disorders
- Respiratory viral infections research
- Nosocomial Infections in ICU
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Mental Health Research Topics
University of Maryland, Baltimore
2023-2024
Background: Elevated blood pressure (BP) is a modifiable risk factor associated with cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on white matter brain aging remains unclear. Methods: In this study, we focused N = 228 473 individuals European ancestry who had genotype data clinical measurements available (103 929 men 124 544 women, mean age 56.49, including 16 901 participants neuroimaging available) collected from UK Biobank (UKB). We first established...
Preliminary evidence suggests that people with schizophrenia have decreased relative abundance of butyrate-producing bacteria in the gut microbiota. Butyrate plays a critical role maintaining integrity gut-blood barrier and has number anti-inflammatory effects. This proof-of-concept study was designed to assess whether addition oligofructose-enriched inulin (OEI) prebiotic: Prebiotin could increase production butyrate.
White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on aging remains unknown. In this study, we assessed using multi-system composite allostatic load (AL) index based inflammatory, anthropometric, respiratory, lipidemia, glucose metabolism measures, investigated its association with age gap (BAG), computed from diffusion tensor imaging data...
Abstract The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9-10 years from 21 sites using standardized protocols for multi-site MRI data collection analysis. While multi-scanner design enhances robustness generalizability analysis results, it may also introduce non-biological variances including scanner-related variations, subject motion, deviations protocols. imaging were...
Abstract The functional connectome changes with aging. We systematically evaluated aging related alterations in the using a whole-brain network analysis 39,675 participants UK Biobank project. used adaptive dense discovery tools to identify networks directly associated from resting-state fMRI data. replicated our findings 499 Lifespan Human Connectome Project Aging study. results consistently revealed two motor-related subnetworks (both permutation test p-values <0.001) that showed...
Abstract An accurate diagnosis is critical to reducing mortality in people with lower respiratory tract infections (LRTIs). Current microbiological culture time-consuming, and nucleic acid amplification-based molecular technologies cannot distinguish between colonization infection. Previously, we described developing a sampling system for effectively capturing biomolecules from human breath. We identified new class of proteoform markers protease activation, termed proteolytic products...
The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9-10 years from 21 sites using standardized protocols for multi-site MRI data collection analysis. While multi-scanner design enhances robustness generalizability analysis results, it may also introduce nonbiological variances including scanner-related variations, subject motion, deviations protocols. imaging were collected...
The American Heart Association introduced Life's Essential 8 (LE8) as a checklist of healthy lifestyle factors to help older individuals maintain and improve cardiovascular health live longer. How LE8 can foster brain aging interact with genetic risk render the less vulnerable dementia is not well understood.
Abstract Background Elevated blood pressure (BP) is a modifiable risk factor associated with cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on white matter (WM) brain aging remains unclear. Methods In this study, we focused N=219,968 non-pregnant, family-unrelated individuals European ancestry who had genotype data two non-null clinical measurements available (99,532 male 120,436 female, mean age=56.55, including 16,901 participants neuroimaging...
Poor glycemic control with elevated levels of hemoglobin A1c (HbA1c) is associated increased risk cognitive impairment, potentially varying effects between sexes. However, the causal impact poor on white matter brain aging in men and women uncertain.
Abstract Introduction Nicotine addiction, a multifaceted neuropsychiatric disorder, profoundly impacts brain functions through interactions with neural pathways. Despite its significance, the impact of tobacco smoking on whole-brain functional connectome remains largely unexplored. Methods We conducted analysis 24,539 adults aged 40 and above from UK Biobank cohort. Subjects were categorized into individuals who use nicotine do not based current chronic information. Functional connectivity...
Abstract The functional connectome changes with aging. We systematically evaluated aging-related alterations in the using a whole-brain network analysis 39,675 participants UK Biobank project. used adaptive dense discovery tools to identify networks directly associated aging from resting-state fMRI data. replicated our findings 499 Lifespan Human Connectome Project Aging study. results consistently revealed two motor-related subnetworks (both permutation test p-values &lt;0.001) that...
Abstract Network analysis of whole-brain connectome data is widely employed to examine systematic changes in connections among brain areas caused by clinical and experimental conditions. In these analyses, the data, represented as a matrix, are treated outcomes, while subject conditions serve predictors. The objective network identify subnetworks whose edges associated with Data-driven powerful approach that automatically organizes individual predictor-related (edges) into subnetworks,...
Abstract White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on aging remains unknown. In this study, we assessed using multi-system composite allostatic load (AL) index based inflammatory, anthropometric, respiratory, lipidemia, glucose metabolism measures, investigated its association with age gap (BAG), computed from diffusion tensor imaging...
APOE4 is a strong genetic risk factor of Alzheimer's disease and associated with changes in metabolism. However, the interactive relationship between plasma metabolites on brain remains largely unknown.In UK Biobank, we investigated moderation effects 249 derived from nuclear magnetic resonance spectroscopy whole-brain white matter integrity, measured by fractional anisotropy using diffusion imaging.The increase concentration metabolites, mainly LDL VLDL, decrease integrity (b= -0.12, CI=...