A5008050394- Extracellular vesicles in disease
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Ear Surgery and Otitis Media
- Sinusitis and nasal conditions
- Diagnosis and treatment of tuberculosis
- RNA regulation and disease
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- Oral microbiology and periodontitis research
- Tuberculosis Research and Epidemiology
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
Translational Health Science and Technology Institute
2021-2024
Jawaharlal Nehru University
2021-2022
To survive and establish its niche, Mycobacterium tuberculosis (Mtb) engages in a steady battle against an array of host defenses barrage antibiotics. Here, we demonstrate that Mtb employs HupB, nucleoid-associated protein (NAP) as key player to simultaneously these two stress-inducing fronts. Typically, NAPs are bacterial survival under wide environmental or host-mediated stresses. report for different macrophage-induced assaults including acidic pH, nutrient depletion, oxidative...
Extracellular vesicles (EVs) have emerged into a novel vaccine platform, biomarker and nano-carrier for approved drugs. Their accurate detection visualization are central to their utility in varied biomedical fields. Owing the limitations of fluorescent dyes antibodies, here, we describe DNA aptamer as promising tool visualizing mycobacterial EVs vitro. Employing SELEX from large library, identified best-performing that is highly specific binds at nanomolar affinity derived three diverse...
An erratum was issued for: Enrichment of Native and Recombinant Extracellular Vesicles Mycobacteria. The Authors section updated from:
Most bacteria, including mycobacteria, generate extracellular vesicles (EVs). Since bacterial EVs (bEVs) contain a subset of cellular components, metabolites, lipids, proteins, and nucleic acids, several groups have evaluated either the native or recombinant versions bEVs for their protective potency as subunit vaccine candidates. Unlike EVs, are molecularly engineered to one more immunogens interest. Over last decade, different explored diverse approaches generating bEVs. However, here, we...
Abstract To survive and establish a niche for themselves, bacteria constantly evolve. Toward that, they not only insert point mutations promote illegitimate recombinations within their genomes but also pieces of ‘foreign’ deoxyribonucleic acid, which are commonly referred to as ‘genomic islands’ (GEIs). The GEIs come in several forms, structures types, often providing fitness advantage the harboring bacterium. In pathogenic bacteria, some may enhance virulence, thus altering disease burden,...
Most bacteria, including mycobacteria, generate extracellular vesicles (EVs). Since bacterial EVs (bEVs) contain a subset of cellular components, metabolites, lipids, proteins, and nucleic acids, several groups have evaluated either the native or recombinant versions bEVs for their protective potency as subunit vaccine candidates. Unlike EVs, are molecularly engineered to one more immunogens interest. Over last decade, different explored diverse approaches generating bEVs. However, here, we...