A5058950559- Meat and Animal Product Quality
- Effects of Environmental Stressors on Livestock
- Adipose Tissue and Metabolism
- Pharmacological Effects and Assays
- Neurological diseases and metabolism
- Growth Hormone and Insulin-like Growth Factors
- Muscle metabolism and nutrition
- Animal Nutrition and Physiology
- Exercise and Physiological Responses
- Lysosomal Storage Disorders Research
- Genetic Neurodegenerative Diseases
- Galectins and Cancer Biology
- RNA regulation and disease
- Genetic Mapping and Diversity in Plants and Animals
University of Nebraska–Lincoln
2020-2024
Abstract Heat stress (HS) triggers oxidative stress, systemic inflammation, and disrupts growth efficiency of livestock. β-adrenergic agonists supplemented to ruminant livestock improve performance, increase skeletal muscle mass, decrease carcass fat. The objective this study was understand the independent interacting effects HS zilpaterol hydrochloride (ZH) supplementation on transcriptome subcutaneous white adipose tissue longissimus dorsi in steers. Twenty-four Red Angus-based steers were...
Abstract The objective of this study was to investigate the effects acute heat stress on skeletal muscle epigenome using reduced representation bisulfite sequencing (RRBS). March-born crossbred (5/8 Red Angus, 3/8 Simmental) steers (n = 14; average body weight 308.7 kg) were exposed (HS) conditions 35°C + 35% relative humidity (Temperature Humidity Index 81) for 12h/d 2 d (48 h). Longissimus dorsi samples collected via biopsy and flash-frozen in liquid nitrogen immediately following HS...
Abstract Background Between 2020 and 2022, eight calves in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) displayed exercise intolerance during forced activity. In some cases, the collapsed did not recover. Available sire pedigrees contained paternal ancestor within 2–4 generations all affected calves. Pedigrees of calves’ dams were unavailable, however, cows ranch-raised retained from prior breeding seasons, where bulls used for occasionally had common ancestor. Therefore, it...
Abstract Bovine familial convulsions and ataxia (BFCA) is considered an autosomal dominant syndrome with incomplete penetrance. Nine Angus calves from the same herd were diagnosed BFCA within days of birth. Necropsy revealed cerebellar spinal cord lesions associated condition. Parentage testing confirmed that all affected had a common sire. The sire was then bred to 36 cows across two herds using artificial insemination, producing additional 14 calves. objective this investigation identify...
Thirteen American Hereford cattle were reported blind with presumed onset when ~12-mo-old. All shared a common ancestor through both the maternal and paternal pedigrees, suggesting recessive genetic origin. Given pedigree relationships novel phenotype, we characterized ophthalmo-pathologic changes associated blindness identified responsible gene variant. Ophthalmologic examinations of 5 revealed retinal degeneration. Histologically, 2 had loss photoreceptor layer. Whole-genome sequencing...
Abstract Between 2020 and 2022, eight calves (6 heifers, 2 bulls) in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) experienced exercise intolerance during extended physical activity. These exhibited an inability to keep pace with the rest of herd, some eventually succumbing collapse from which they did not recover. Increased creatine kinase, indication muscle degeneration, was confirmed biopsy necropsy samples. Available sire pedigrees revealed common paternal ancestor within 4...
Abstract The response to zilpaterol hydrochloride supplementation by two breeds of beef steers under controlled heat stress conditions were evaluated for impacts on growth, carcass merit, and physiological indicators. In separate studies, Brahman Angus placed in environmental chambers housed 21 d 1 2 1) (THI = 73 85) or thermoneutral 68). a x factorial, also received 8.38 mg· kg-1· d-1 88% DM (ZH) soybean meal carrier only the 21-d period. Feed intake, respiratory rate, rectal temperatures...
Abstract Red Angus steers (n = 24; 260 ± 25 kg) were used to analyze the effects of supplementation zilpaterol hydrochloride (ZH) under heat stress conditions on respiration rate (RR), rectal temperature (RT), growth performance (GP), and carcass traits (CT). Steers randomly assigned a 2 x factorial treatment arrangement 6/group) with factors including (HS; THI=71 83) or thermal neutral (TN; THI=27 39) with/without ZH (0 8.38 mg/kg/d 88% DM basis). provided 9 d acclimate tie stalls rooms TN...
Abstract Heat stress (HS) negatively impacts livestock performance and carcass traits while beta-adrenergic agonist (βAA) supplementation improves animal production efficiency; both can stimulate lipolysis in adipose. The objective of this study was to understand the independent interacting effects HS βAA on subcutaneous adipose transcriptome lambs visceral fatty acid mobilization steers. For 1, 24 wethers were assigned thermal neutral (TN THI = 65) or (THI 80) conditions supplemented...
Abstract Heat stress reduces livestock performance while supplementation of beta-adrenergic agonists (βAA) such as zilpaterol hydrochloride (ZH) improve production efficiency; both stimulate lipolysis. The objective this study was to understand the effects (independent, interacting) heat and ZH on subcutaneous adipose transcriptome in fed steers. 24 Red Angus steers were assigned thermoneutral (TN; THI=68) or (HS; THI=83) conditions no supplement (NS) (8.33 mg/kg/day) for 21d a 2x2...