A5047768241- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
École Polytechnique
2022-2025
Inserm
2023-2025
Centre National de la Recherche Scientifique
2023-2025
Abstract Cell migrations are crucial for embryonic development, wound healing, the immune response, as well cancer progression. During mesenchymal cell migration, Rac1-WAVE-Arp2/3 signalling pathway induces branched actin polymerisation, which protrudes membrane and allows migration. Fine-tuning activity of modulates protrusion lifetime migration persistence. Recently, NHSL1, a novel interactor Scar/WAVE complex has been identified negative regulator in vitro. We here analysed its function...
Summary Cell migrations are crucial for embryonic development, wound healing, the immune response, as well cancer progression. During mesenchymal cell migration, Rac1-WAVE-Arp2/3 signalling pathway induces branched actin polymerisation, which protrudes membrane and allows migration. Fine-tuning activity of modulates protrusion lifetime migration persistence. Recently, NHSL1, a novel interactor Scar/WAVE complex has been identified negative regulator in vitro . We here analysed its function...
Summary Morphogenesis, wound healing and some cancer metastases depend upon migration of cell collectives that need to be guided their destination as well coordinated with other movements. During zebrafish gastrulation, extension the embryonic axis is led by mesendodermal polster migrates towards animal pole, followed axial mesoderm undergoes convergence extension. We here investigate how cells are pole. Using a combination precise laser ablations, advanced transplants functional in silico...