A5011604909- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Food Security and Health in Diverse Populations
- Folate and B Vitamins Research
- GDF15 and Related Biomarkers
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Risk Factors
- Health disparities and outcomes
- Employment and Welfare Studies
- Sleep and related disorders
- Frailty in Older Adults
- Head and Neck Cancer Studies
- COVID-19 Pandemic Impacts
- Agricultural risk and resilience
- Sleep and Work-Related Fatigue
- Optimism, Hope, and Well-being
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Retirement, Disability, and Employment
- Metabolism, Diabetes, and Cancer
- Housing, Finance, and Neoliberalism
- Geriatric Care and Nursing Homes
- Nutrition, Health and Food Behavior
- Aging and Gerontology Research
National Institute on Aging
2023-2025
University of Illinois Urbana-Champaign
2019-2024
National Institutes of Health
2023-2024
The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown. Data from 3953 UK Biobank participants were used (40-70 years, 2006-2010), with a neuroimaging visit 2014 2021. Poor CVH was determined using Life's Essential 8 (LE8) reversing standardized z-scores (LE8z _rev). proteome examined as potential mediator moderator of LE8z _rev's effects on quantitative...
This cross-sectional study explored the associations between spiritual transcendence (ST) - prayer/meditation fulfillment, connectedness, and universality American Heart Association's Life's Simple 7 (LS7), if variations across within racial socioeconomic groups emerged. Data were taken from Healthy Aging in Neighborhoods of Diversity Life Span included 1,110 midlife older African (AA) White adults (mean [standard deviation] age=56.13 [8.91] years; 65.0% above poverty; 78.1% ≥ high school...
Improving care for the older population is a growing clinical need in United States. Ageism and other attitudes of healthcare professionals can negatively impact adults. This study investigated professionals' (N = 140) views towards aging characterized confluence factors influencing ageism perspectives workers using path analysis models. These models proposed relationships between anxiety, expectations regarding aging, age, ageism, knowledge. Aging anxiety had less critical role final model...
The plasma proteome can mediate the association of hospital-treated infections with dementia incidence. We screened up to 37,269 UK Biobank participants aged 50–74 years for presence a prevalent infection, subsequently tested as predictor ≤1,463 proteins and Four-way decomposition models decomposed infection-dementia total effect into pure mediation, interaction, neither or both through proteome. Hospital-treated increased two-fold. strongest mediation was growth differentiation factor 15...
No studies, to date, have examined the relationship between dietary fiber and recurrence or survival after head neck cancer diagnosis. The aim of this study was determine whether pretreatment intake whole grains predicted outcomes in newly diagnosed (HNC) patients. This a prospective cohort 463 participants baring new diagnosis who were recruited into prior initiation any therapy. Baseline (pre-treatment) clinical data measured upon entry cohort. Clinical ascertained at annual medical...
Background: Loneliness, dementia, and mortality are interconnected. Objective: We aimed at understanding mediating pathways interactions between loneliness dementia in relation to risk. Methods: The study tested bi-directional relationships loneliness, mortality, by examining both effects a large sample of older US adults participating the nationally representative Health Retirement Study. Out of≤6,468 participants selected 2010, with mean baseline age 78.3 years follow-up time up end 2020,...
Abstract Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels anxiety. We examined longitudinal adults, before after stratifying by anxiety level, using data from 1460 Healthy Aging in Neighborhoods Diversity the Lifespan Study (HANDLS) participants aged 30–64 y at v 1 (2004–2009), followed 3 visits up to 2017. In addition LnHcy v1 , we used group-based trajectory models predicting...
Head and neck squamous cell carcinoma (HNSCC) is a class of heterogenous cancers involving the upper aerodigestive tract. We previously demonstrated utility
(1) Background: Food insecurity (FI) is a public health and sociodemographic phenomenon that besets many cancer survivors in the United States. FI may arise as consequence of financial toxicity stemming from treatment costs, physical impairment, labor force egress, or combination those factors. To our knowledge, an understanding dietary intake practices this population has not been delineated but imperative for addressing needs vulnerable population; (2) Methods: Using data NHANES,...
Dietary intake is understood to contribute nutrition impact symptoms (NIS) in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of this study was evaluate the performance four a priori-defined diet quality indices on presence NIS 1 year following diagnosis using data 323 participants from University Michigan Head Neck Specialized Program Research Excellence (UM-SPORE). Pretreatment dietary measured before treatment initiation food frequency questionnaire. were along...
No studies, to date, have scrutinized the role of a priori dietary patterns on prognosis following head and neck squamous cell carcinoma (HNSCC) diagnosis. The purpose this analysis was evaluate associations between adherence six defined diet quality indices (including AHEI-2010, aMED, DASH, three low-carbohydrate indices) throughout first 3 years observation all-cause cancer-specific mortalities in 468 newly diagnosed HNSCC patients from University Michigan Head Neck Specialized Program...
Evidence points to associations between sleep quality, dementia, and mortality. We examined whether poor quality mediated or moderated the association dementia mortality risk among older US adults vice versa, these differed by sex race.
Abstract Background Housing instability is a known barrier to healthcare utilization potentially affecting the prevention, diagnosis and treatment of chronic diseases among diverse groups adults. We examined intersection recent housing with prevalent cardiovascular disease, diabetes, cancer psychiatric diagnoses aging Methods Cross-sectional data on 147 465 participants ‘All Us’ Research Program (6 May 2018–1 July 2022), ≥50 years age at enrollment, were analyzed. Self-reported over past 6...
Abstract Alzheimer’s Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk’s relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006–2010) were followed-up for ≤ 15 y incidence. Plasma proteomics performed on sub-sample of ( k = 1,463 proteins). AD risk scores (PRS) used as primary exposure and Cox proportional hazards models conducted examine PRS-dementia...
Background Sleep, cognition, and mortality may be interdependent. Objective We explored paths between sleep, cognition potential interactions. Methods The study examines the relationship among global mental status, risk using data from 1364 participants Healthy Aging in Neighborhood of Diversity across Life Span (HANDLS) study. used Cox proportional hazards models four-way decomposition to analyze sleep patterns status. Results After a median time at 8.2 years, 172 deaths occurred, with rate...
Abstract Background Loneliness, dementia, and mortality are interconnected. Thus, understanding the pathways, along with their potential interaction provides a relevant area of research to be developed. Method The study tested bi‐directional relationships between loneliness mortality, while examining both interactions mediating effects in large sample older US adults participating nationally representative Health Retirement Study. Out ≤6,468 participants selected 2010, mean baseline age 78.3...
Abstract Purpose Food insecurity—the lack of unabated access to nutritious foods—is a consequence many cancer survivors face. insecurity is associated with adverse health outcomes and lower diet quality in the general public. The goal this analysis was extract major prevailing dietary patterns among food insecure from observed 24-h recall data evaluate their relationship survival after diagnosis. Methods We implemented two approaches: penalized logistic regression principal components...