A5014860981- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Genomic variations and chromosomal abnormalities
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Genomics and Rare Diseases
First Affiliated Hospital of Kunming Medical University
2020-2024
Kunming Medical University
2020-2024
Abstract Schizophrenia (SCZ) is influenced by a combination of genetic and environmental factors. Although several studies have been conducted to identify the causative loci genes, few these or genes can be repeated due high phenotypic heterogeneity disease, their mechanisms are not fully understood. There may some “missing heritability” that has yet found. In order investigate deleterious heritable mutations, whole‐exome sequencing (WES) in pedigrees with SCZ was used current work. Two...
Schizophrenia (SCZ) is a prevalent, severe, and persistent mental disorder with an unknown etiology. Growing evidence indicates that immunological dysfunction vital in the development of SCZ. Our study aims to uncover potential immune-linked hub genes immune infiltration characteristics SCZ, as well develop diagnostic model based on central genes. GSE38484 GSE54913 chip expression data for patients SCZ healthy controls were retrieved. Weighted gene co-expression network analysis (WGCNA) was...
To explore the relationship between cognitive function and blood-brain barrier leakage in non-brain metastasis lung cancer healthy controls. 75 cancers without brain 29 controls matched with age, sex, education were evaluated by assessment, Patlak pharmacokinetic model was used to calculate average each region according automated anatomical labeling atlas. After that, relationships evaluated. Compared controls, of bilateral temporal gyrus whole higher patients (P < 0.05), mainly advanced but...
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Bipolar disorder (BD) is a debilitating neuropsychiatric disorder, which associated with genetic variation through "vast but mixed" Genome-Wide Association Studies (GWAS). Transcriptome-Wide Study (TWAS) more effective in explaining factors that influence complex diseases and can help identifying risk genes reliably. So, this study aims to identify potential BD pedigrees TWAS.
Abstract Background: To explore the relationship between cognitive function and blood-brain barrier leakage in non-brain metastasis lung cancer healthy controls. Methods: 75 cancers without brain 29 controls matched with age, sex, education were evaluated by assessment, Patlak pharmacokinetic model was used to calculate average each region according automated anatomical labelling atlas. After that, relationships evaluated. Results: Compared controls, of 3 regions higher patients early...