A5092500315- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Microtubule and mitosis dynamics
- Environmental DNA in Biodiversity Studies
- Glioma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Evolution and Genetic Dynamics
- Single-cell and spatial transcriptomics
Queen Mary University of London
2023-2025
The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while different chromosomes assort independently
Abstract Glioblastoma (GBM) is the most aggressive form of primary brain tumor. The infiltrative nature GBM makes complete surgical resection impossible. selective forces that govern gliomagenesis are strong, shaping composition tumor cells during initial progression to malignancy with late consequences for invasiveness and therapy response. Here, we developed a mathematical model incorporates ploidy level tissue microenvironment simulate growth invasion used make inferences about initiation...
ABSTRACT The chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes different chromosomes assort independently, providing a fundamental tenet Mendelian inheritance. Extrachromosomal DNA (ecDNA) is frequent event in that drives oncogene amplification, dysregulated gene expression and intratumoral heterogeneity, through random segregation during cell division. Distinct ecDNA sequences, herein termed...
Abstract Extrachromosomal DNA (ecDNA) emerges as a crucial promoter of rapid intra-tumour heterogeneity and oncogene amplification, contributing to tumour progression adaptability resistance. Multiple types ecDNA are often observed within the same cancer cell, promoting high levels complexity. While study multiple is still in its early stages with exciting new clinical experimental studies human cancers, few theoretical models have been proposed understand mechanisms enabling maintenance...
Extrachromosomal DNA (ecDNA) can drive oncogene amplification, gene expression and intratumor heterogeneity, representing a major force in cancer initiation progression. The phenomenon becomes even more intricate as distinct types of ecDNA present within single cell. While exciting new significant observation across various types, there is lack general framework capturing the dynamics multiple theoretically. Here, we novel mathematical models investigating proliferation expansion growing...
Abstract Resource limitations shape the outcome of competitions between heterogeneous pre-malignant cells. One example such heterogeneity is in ploidy (DNA content) High-ploidy cells need more resources, to synthesize increasing amounts DNA, RNA and proteins. To model how subpopulations with variable DNA-content compete resource limited environment human brain we developed a stochastic state-space (S3MB). The discretizes into voxels, whereby state each voxel defined by 8+ variables that are...
Abstract Glioblastoma (GBM) is the most aggressive form of primary brain tumor. Complete surgical resection GBM almost impossible due to infiltrative nature cancer. While no evidence for recent selection events have been found after diagnosis, selective forces that govern gliomagenesis are strong, shaping tumor’s cell composition during initial progression malignancy with late consequences invasiveness and therapy response. We present a mathematical model simulates growth invasion glioma,...