A5062102759- Cancer Genomics and Diagnostics
- Evolution and Genetic Dynamics
- Fault Detection and Control Systems
- Single-cell and spatial transcriptomics
- Dynamics and Control of Mechanical Systems
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Hydraulic and Pneumatic Systems
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Electromagnetic Launch and Propulsion Technology
- Advanced biosensing and bioanalysis techniques
- Advanced Sensor and Control Systems
- Structural Response to Dynamic Loads
- Cancer-related molecular mechanisms research
Stanford University
2023-2024
Tongji University
2022
Nanjing University of Science and Technology
2022
The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while different chromosomes assort independently
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution drug resistance and poor outcomes. Applying computational methods for the detection reconstruction ecDNA across a retrospective cohort 481 medulloblastoma from 465 patients, we identify circular 82 patients (18%). Patients with ecDNA-positive were more than twice as likely to relapse three times die within 5 years diagnosis. A subset harbored multiple lineages, each...
Extrachromosomal DNA (ecDNA) is a hallmark of aggressive cancer, contributing to both oncogene amplification and tumor heterogeneity. Here, we used Hi-C, super-resolution imaging, long-read sequencing explore the nuclear architecture
ABSTRACT The chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes different chromosomes assort independently, providing a fundamental tenet Mendelian inheritance. Extrachromosomal DNA (ecDNA) is frequent event in that drives oncogene amplification, dysregulated gene expression and intratumoral heterogeneity, through random segregation during cell division. Distinct ecDNA sequences, herein termed...
In order to meet the particular environment and requirements of launch, model vibration characteristics a complex launch structure system need be analyzed. this paper, is regarded as multi-rigid-flexiblebody using transfer matrix method for multibody systems (MSTMM). By establishing relationship between various components, overall equation are obtained, then natural frequencies computed. Compared with finite element computed results, effectiveness verified. putting transient load on bottom...
To realize the static loading function, a new servomechanism using servo-proportional valve to control multi-chambers servo-cylinder is introduced in this paper. The boasts four working ports connected relative servo-cylinder, which can movement of and auxiliary brake, precise force position load test. analyze factors taking strategy step current application, give description on why how achieve demand performance based configuration. Thanks special construction valve, its flow gradient...