A5042188968- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Treatment of Major Depression
- Epilepsy research and treatment
- Poisoning and overdose treatments
- Analytical Chemistry and Chromatography
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Cholinesterase and Neurodegenerative Diseases
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Metabolomics and Mass Spectrometry Studies
Saarland University
2020-2024
The new psychoactive substances (NPS) market continues to be very dynamic. A large number of compounds belonging diverse chemical groups continue emerge. This makes their detection in biological samples challenging for clinical and forensic toxicologists. Knowledge the metabolic fate NPS is crucial developing comprehensive screening procedures. As human studies are not feasible due ethical concerns, current study aimed compare NPS' pattern incubations with pooled liver S9 fraction (pHLS9),...
Ketamine derivatives such as deschloroketamine and deschloro-N-ethyl-ketamine show dissociative psychoactive properties their abuse new substances (NPSs) has been reported. Though some information is available on the biotransformation of NPSs, data deschloro-N-cyclopropyl-ketamine deschloro-N-isopropyl-ketamine deschloro-N-propyl-ketamine concerning and, thus, urinary detectability are not available. The aims presented work were to study in vivo phase I II metabolism; vitro metabolism, using...
Wastewater (WW)-based epidemiology is an approach for the objective surveillance of consumption (illicit) drugs in populations. The aims this study were to monitor abuse, cognitive enhancers, and their metabolites as biomarkers influent WW. Data obtained from different sampling points mean daily loads compared with previously published data. prevalence analytes was monitored WW grab samples collected monthly over 22 months at two 24 h composite 2 weeks a treatment plant same city....
Sewage-based epidemiology using influent wastewater is used to estimate the consumption trends of (illicit) drugs over a short or long period time in subpopulation. The current study aimed develop two separate methods for quantitative analysis selected abuse (DOA) and cognitive enhancers reversed-phase (RP) hydrophilic interaction liquid chromatography (HILIC) coupled high-resolution tandem mass spectrometry (LC-HRMS/MS). performance RP HILIC column was evaluated. A simple solid phase...
Wastewater (WW)-based epidemiology (WBE) is a powerful tool for screening and surveillance of drugs (of abuse) or new psychoactive substances (NPSs) in larger population. Since the drug market changes frequently, it crucial WBE to define biomarkers considering metabolism (microbial) stability. The aims presented work were first identify metabolites, potentially serving as biomarker five deschloroketamine derivatives (DCKDs) rat feces samples after oral administration addition already known...
Chloroquine, a drug approved for the treatment of malaria, is frequently used to commit suicide. We report about suicide attempt by ingesting high dose chloroquine in combination with other drugs. Findings emergency toxicology screening blood and urine those follow-up analyses are discussed. Systematic toxicological analysis approaches revealed presence chloroquine, butylscopolamine, cafedrine, diazepam, lorazepam, metoclopramide, nordazepam, norephedrine...