A5111142490- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Dysphagia Assessment and Management
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Medical Imaging Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Esophageal and GI Pathology
- Reconstructive Surgery and Microvascular Techniques
- Facial Nerve Paralysis Treatment and Research
- Nutrition and Health in Aging
- Meningioma and schwannoma management
- Airway Management and Intubation Techniques
- Lung Cancer Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Neurofibromatosis and Schwannoma Cases
- Esophageal Cancer Research and Treatment
- Oral Health Pathology and Treatment
- Magnetic properties of thin films
- Oral health in cancer treatment
- Trigeminal Neuralgia and Treatments
University Medical Center Utrecht
2013-2024
University of Cologne
2024
Heidelberg University
2014-2017
University Hospital Heidelberg
2014-2017
Central Military Hospital
2009-2010
Gelre Hospitals
2010
Erasmus University Rotterdam
2006-2010
Erasmus MC
2006-2010
To investigate the relationship between histologic characteristics of head and neck squamous cell carcinoma apparent diffusion coefficient (ADC) at diffusion-weighted magnetic resonance (MR) imaging.The institutional ethics committee approved this study waived informed consent. In carcinoma, local failure after chemotherapy and/or radiation therapy correlates with pretreatment ADC. However, histopathologic basis correlation remains unclear. study, 16 patients were enrolled (median age, 60...
Low skeletal muscle mass (SMM) is associated with postoperative complications, prolonged hospital stay, and short overall survival (OS) in surgical oncology. We aimed to investigate this association patients undergoing total laryngectomy (TL).A retrospective study was performed of TL. SMM measured using CT or MRI scans at the level third cervical vertebra (C3).In all, 235 were included. observed 109 (46.4%). Patients low had more pharyngocutaneous fistulas (PCFs) than normal (34.9% vs 20.6%;...
Background: Recurrent laryngeal nerve (RLN) injury caused by esophagectomy may lead to postoperative morbidity, however data on long-term recovery are scarce. The aim of this study was evaluate the consequences RLN palsy (RLNP) in terms pulmonary morbidity and functional recovery. Methods: Patients who underwent a 3-stage transthoracic (McKeown) or transhiatal for esophageal carcinoma University Medical Center Utrecht (UMCU) between January 2004 March 2016 were included from prospective...
Identification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is great importance. Human papillomavirus (HPV)-positive HNSCCs have favorable response to (chemo)radiotherapy. Apparent diffusion coefficient, derived from diffusion-weighted MRI, has also shown predict treatment response. The purpose this study was evaluate the correlation between HPV status apparent coefficient.Seventy-three patients with histologically proven HNSCC were retrospectively...
Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of apparent diffusion coefficient (ADC) for response prediction and monitoring, less known about biological background ADC. In tumor microenvironment, hypoxia increased proliferation cells contribute to resistance (radio-)therapy, while high T-cell influx related better prognosis. We investigated correlation between these three tissue...
Abstract Background To investigate if depth of invasion (DOI) can predict occult nodal disease in patients with cT1‐2N0 (7th TNM) oral squamous cell carcinoma (OSCC) staged by sentinel lymph node biopsy (SLNB). Methods In 199 OSCC patients, DOI measurements and SLNB were performed. Results Metastases found 64 (32%). Of these the mean was 6.6 mm compared to 4.7 without metastases ( P = .003). The ROC‐curve showed an area under curve 0.65 a most optimal cutoff point 3.4 (sensitivity 83%...
The aim of the present study was to elucidate systematic topography lateral sellar (cavernous sinus [CS]) nerve plexus and its connections in humans.Seven specimens human CS adjacent regions were dissected steps stained as whole-mount preparations by using a sensitive acetylcholinesterase method. Another specimen frozen, cut on frontal plane, for acetylcholinesterase. contains an extensive with small ganglia. is composed main part, proper, which located around abducent medial ophthalmic...
Background and purpose. To determine the spatial correspondence between gross tumor volume (GTV) delineated on computer tomography (CT) actual histopathology.Material methods. Sixteen patients with T3 or T4 laryngeal hypopharyngeal cancer underwent a CT scan before total laryngectomy. The GTV was by three independent observers consensus observers. After surgery, whole-mount hematoxylin-eosin stained (H&E) sections were obtained. One pathologist in H&E (tumorH&E). reconstructed specimen...
Neopharyngeal stenosis is a recognized sequela of total laryngectomy (TL). We aim to investigate the incidence requiring dilation, risk factors for and complications dilation.Retrospective cohort study patients undergoing TL in two dedicated head neck centers Netherlands.A 477 patients, (81% men, median age 64 at TL) were included. Indication was previously untreated primary tumor 41%, salvage following (chemo)radiotherapy (CRT) 44%, dysfunctional larynx 9% second 6%. The cumulative...
Objectives: Surgical manipulation of cartilage tissue is associated with chondrocyte death in the wound edges that hinders integration. The objective this study was to evaluate effect a short course treatment graft combination hyaluronidase and collagenase on density integrative capacity. Methods: Cartilage explants were treated enzymes for various time periods at concentrations. A central core punched out larger explant, enzymes, reimplanted, placed subcutaneously athymic mice. number...
Recent research shows that quasiparticle-induced decoherence of superconducting qubits depends on the superconducting-gap asymmetry originating from different thicknesses top and bottom films in Al/AlOx/Al junctions.Magnetic field is a key tuning knob to investigate this dependence as it can change gaps situ.We present measurements parity-switching time field-resilient 3D transmon with in-plane up 0.41 T. At low fields, small parity splitting requires qutrit pulse sequences for...
Laryngotracheal reconstruction requires a supportive structure with mucosal lining, which needs vascular supply in order to regenerate properly. We investigated the necessity of carrier and graft when using porous titanium for laryngotracheal reconstruction. Surgical defects complex 22 rabbits were reconstructed with: (a) implanted on vascularized fascia combined buccal (first stage) before transposing neck area (second stage); (b) (c) pedicled flap; (d) alone. The grafts tolerated well....
Pretreatment identification of radio-insensitive head and neck squamous cell carcinomas (HNSCC) would affect treatment modality selection. The apparent diffusion coefficient (ADC) a tumor could be predictor local recurrence. However, little is known about its prognostic value next to factors such as clinical T-stage. aim the present study determine added pretreatment ADC T-stage factor for recurrence.This retrospective cohort included 217 patients with HNSCC treated (chemo)radiotherapy...
To investigate whether porous titanium can provide a better support for revascularization of mucosal graft ideal tracheal reconstruction. In patients with laryngotracheal stenosis or tumor, the mucosa supporting structures be damaged, resulting in defect that has to reconstructed. Autologous tissues like cartilage and have been used The main problem incomplete reepithelialization.In first experiment, ear was combined implanted subcutaneously athymic mice different periods time. second using...
We investigate the effect of magnetic field on a photonic-crystal Josephson traveling-wave parametric amplifier (TWPA). show that observed change in photonic bandgap and plasma frequency TWPA can be modeled by considering suppression critical current junctions (JJs) due to Fraunhofer closing superconducting gap. Accounting for JJ geometry is crucial understanding dependence. In one in-plane direction, shifted 2 GHz using up 60 mT field, without losing gain or bandwidth, showing TWPAs SQUIDs...
Background: The role of 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET)/computed (CT) in routine diagnostic staging remains controversial. In case discordance between FDG-PET and CT, a compromise has to be made the risk false positive delaying appropriate salvage intervention. Second, with intensity modulated radiation therapy (IMRT), smaller fields allow tissue sparing, but could also lead more marginal failures.Methods: We retrospectively studied 283 patients head...
Background and Objective Current resection modalities for oral squamous cell carcinomas (OSCC) vary from cold steel over CO 2 laser to monopolar electro‐surgery (MO). We compared thulium (TL) as a new modality with MO regards pathological assessment. Study Design/Materials Methods Forty‐two patients who were treated OSCC by either TL or included. All resected specimens assessed special attention margin interpretation thermal damage. Results Depth of damage ranged 1.0 3.5 mm in the group...
de Ru, Jacob A. M.D., Ph.D.; van Benthem, Peter Paul G. Janssen, Luuk M. M.D. Author Information