A5073640321- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Computational Drug Discovery Methods
- interferon and immune responses
- T-cell and B-cell Immunology
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Biosensors and Analytical Detection
Tianjin University
2023-2024
CRISPR-Cas9 has been explored as a therapeutic agent for down-regulating target genes; the controlled delivery of Cas9 ribonucleoprotein (RNP) is essential efficacy and remains challenge. Here, we report cascade dynamic assembly/disassembly DNA nanoframework (NF) that enables RNP. NF was prepared with acrylamide-modified initiated hybridization chain reaction (HCR). Through an HCR, single-guide RNA incorporated to NF; simultaneously, internal space expanded, facilitating loading protein....
RNA molecules are essential regulators of biological processes and promising therapeutic targets for various diseases. Discovering small that selectively bind to specific conformations remains challenging due RNA's structural complexity the limited availability high-resolution data. Herein, we introduce GerNA-Bind, a geometric deep learning framework predict RNA-ligand binding specificity by integrating multi-state representations interactions. GerNA-Bind achieves state-of-the-art...