A5037781966- Phytochemistry and biological activity of medicinal plants
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Phosphodiesterase function and regulation
- Genetic Associations and Epidemiology
- Analytical Chemistry and Chromatography
- Cancer Mechanisms and Therapy
- Anorectal Disease Treatments and Outcomes
- Natural Compounds in Disease Treatment
- melanin and skin pigmentation
- Cholinesterase and Neurodegenerative Diseases
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Diverticular Disease and Complications
- Phytochemicals and Antioxidant Activities
- Genetics and Neurodevelopmental Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Bioactive Compounds in Plants
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects of Natural Compounds
Weatherford College
2024
Yangpu Hospital of Tongji University
2024
Sun Yat-sen University
2012-2014
Accumulating evidences have indicated that lipid-lowering drugs effect for the treatment of cancers. However, causal associations between and risk cancers are still unclear. In our study, we utilized single nucleotide polymorphisms proprotein convertase subtilis kexin 9 (PCSK9) inhibitors 3-hydroxy-3-methylglutaryl-assisted enzyme A reductase (HMGCR) performed a drug target Mendelian randomization to explore association Five regression methods were carried out, including inverse variance...
Multi-component analysis has been considered to be one of the key techniques for quality control traditional Chinese medicines. However, shortage and high cost reference standards have become greatest obstacles in implementing this goal. An alternative method using only an easily available standard as internal determine multiple analogues gained increasing attention. In present study, a practical HPLC was established simultaneous quantification seven chromones Aloe barbadensis Miller single...
Introduction Chromones and pyrones are the major secondary metabolites of Aloe barbadensis Miller. As they minor components plant, an efficient purification procedure for them is great importance promoting their pharmacological studies. Objective To develop methods one-step separation two chromones (5-((S)-2′-oxo-4′-hydroxypentyl)-2-hydroxymethylchromone (1) 5-((4E)-2′-oxo-pentenyl)-2-hydroxymethylchromone (3)) one pyrone (aloenin aglycone (2)) from A. via reversed-phase flash chromatography...
Aloin, isoaloeresin D, and aloenin-2′-p-coumaroyl ester were separated purified from Aloe barbadensis Mill by one step of high-speed counter-current chromatography for the first time. The separation was performed with an optimized two-phase solvent system composed hexane-ethyl acetate- acetone-water (0.2:5:1.5:5, v/v/v/v), using lower phase as mobile in head-to-tail elution mode. revolution speed column, flow rate phase, UV detection wavelength 860 rpm, 1.5 mL · min−1, 300 nm, respectively....
Evidence from observational researches have suggested that mental diseases are able to affect thyroid diseases. However, the causal relationship between and risk of still remains unclear. Herein, we conducted a two-sample Mendelian randomization (MR) statistical analysis method assess causality Initially, publicly available genome-wide association studies summary data were leveraged obtain single-nucleotide polymorphisms based on set parameters. Subsequently, MR was utilized analyze...
<title>Abstract</title> <bold>Objective</bold> To explore the single-center clinical experience of polydocanol foam in antithrombotic treatment mixed hemorrhoid patients with bleeding and review related literature.<bold>Methods</bold> From March 2018 to May 2023, we retrospectively analyzed data 7 who were admitted General Surgery Department Yangpu Hospital affiliated Tongji University. Patients therapy combined failed receive conservative need be treated injection sclerotherapy. We...
A bioactive chromone, 8-C-glucosyl-7-O-methyl-(S)-aloesol (compound 1), was prepared by the acid-catalyzed hydrolysis of isoaloeresin D in Aloe barbadensis Miller. The conditions were successfully optimized response surface methodology (RSM). results indicated that RSM present study adequate and effective. Then, reversed-phase flash chromatography utilized for isolation. In a one-step operation within 45 min, 26 mg compound 1 isolated from 153 product, with purity 99.3%. These achievements...
We report a new method of aloe-emodin separation and purification that is based on the simplex optimization an acetone-ammonium sulfate aqueous double-phase system. investigated partitioning trends conditions this system identified optimized recipe for purification. With recipe, was extracted at purity 95.23%. The reported here only requires simple equipment, mild experimental conditions. operations are cheap easy, produce products with high yield. Thus, effective in optimizing systems...