A5029171060- Melanoma and MAPK Pathways
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Retinal Development and Disorders
- Cellular Mechanics and Interactions
- Erythrocyte Function and Pathophysiology
- Sphingolipid Metabolism and Signaling
- Spaceflight effects on biology
- Endoplasmic Reticulum Stress and Disease
Huazhong University of Science and Technology
2024
At the synapse, presynaptic neurotransmitter release is tightly controlled by machinery, involving soluble N -ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins and Munc13. The Ca 2+ sensor Doc2 cooperates with Munc13 to regulate release, but underlying mechanisms remain unclear. In our study, we have characterized binding mode between found that originally occludes inhibit SNARE complex assembly. Moreover, investigation unveiled EphB2, a adhesion molecule (SAM)...
Despite medical interventions, the regenerative capacity of peripheral nervous system is limited. Dorsal root ganglion (DRG) neurons possess to detect mechanical signals from their microenvironment, but impact and mechanism by which these regulate axon regrowth even regeneration in DRG remain unclear. In this study, newborn rats are cultured on substrates with varying degrees stiffness vitro investigate role regrowth. The findings reveal that substrate plays a crucial regulating regrowth, an...