A5018005804- Medical Imaging Techniques and Applications
- Schizophrenia research and treatment
- Radiopharmaceutical Chemistry and Applications
- Fluorine in Organic Chemistry
- Cancer Treatment and Pharmacology
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Selenium in Biological Systems
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Amino Acid Enzymes and Metabolism
- HER2/EGFR in Cancer Research
- S100 Proteins and Annexins
- Galectins and Cancer Biology
- Mycobacterium research and diagnosis
- Neuroscience and Neuropharmacology Research
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Electroconvulsive Therapy Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Whipple's Disease and Interleukins
University of Groningen
1989-2024
University Medical Center Groningen
2023-2024
Ruhr University Bochum
2006
Heart and Diabetes Center North Rhine-Westphalia
1996-2003
Abstract Aims Heart failure (HF) is recognized as an inflammatory disease in which cytokines play important role. In animal HF models, interleukin‐17A (IL‐17) has been linked to deterioration of cardiac function and fibrosis, whereas knock‐out IL‐17 showed beneficial effects. However, there limited evidence involvement patients with HF. This study aims investigate the clinical characteristics, outcomes, pathophysiological processes associated circulating concentrations Methods results was...
Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum blood biomarker and transcriptomic profiles patients HF.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBehavior of reaction mixtures under microwave conditions: use sodium salts in microwave-induced N-[18F]fluoroalkylations aporphine and tetralin derivativesS. Zijlstra, T. J. De Groot, L. P. Kok, G. M. Visser, W. VaalburgCite this: Org. Chem. 1993, 58, 7, 1643–1645Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March...
The transforming growth factor-β (TGF-β) superfamily member, myostatin, is a negative regulator of muscle and may contribute to adverse cardiac remodeling. Whether suppressing myostatin could benefit pressure-overloaded heart remains unclear. We investigated the effects pharmacological inhibition on fibrosis hypertrophy in mouse model pressure overload induced by transverse aortic constriction (TAC). Two weeks after surgery, TAC sham mice were randomly divided into groups receiving mRK35,...
Although DWORF overexpression significantly delayed heart failure development and strongly prolonged life span in PLN-R14del mice, the current study shows that deletion of does not accelerate or exacerbate cardiomyopathy mice harboring pathogenic R14del allele. In addition, appears to be dispensable for cardiac function during aging. Changes gene expression are therefore unlikely contribute clinical heterogeneity observed patients with cardiomyopathy.
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Dutch Research Council, through the Open Competition ENW-KLEIN grant Background Low selenium concentrations are associated with worse outcomes in patients heart failure (HF). However, underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum blood proteomic and transcriptomic profiles HF. Methods Circulating proteins, whole...
Abstract Background Heart Failure (HF) is characterized by impediments in exercise capacity. Disruptions the energy metabolism of skeletal muscle contribute to this condition. Pre-clinical and clinical evidence showed that reductions carbohydrate FA HF may be partially overcome a compensatory increase ketone body oxidation suggest suppletion bodies (KB) improve HF. Purpose We tested effect exogenous KB on pH balance during cycling using 31P Magnetic Resonance (MR) Spectroscopy exercising...
Louwerens, J. W.; Buddingh', A.; Zijlstra, S.; Pruim, J.; Korf, Paans, A MJ.; Slooff, C J Author Information