A5068438387- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Electrospun Nanofibers in Biomedical Applications
- Congenital heart defects research
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
ProteinQure (Canada)
2024
University of Toronto
2020
University of Wisconsin–Madison
2019
The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 skew humoral immune response toward generating abnormal immature memory cells (MB), while impairing plasma differentiation. At molecular level, mutants co-opt SMRT/HDAC3 repressor complexes binding MB transcription factor (TF) BACH2 at expense of germinal center (GC) TF BCL6, leading to pre-memory transcriptional...
Abstract Sortilin (SORT1) is a member of the vacuolar protein sorting 10 (Vps10p) family that functions as receptor regulating peptide and trafficking between plasma membrane, lysosomes, trans-golgi network. As cell surface receptor, SORT1 able to mediate efficient endocytosis extracellular ligands lysosomal compartment. Numerous reports have identified enriched expression in variety tumor types, including triple-negative breast cancer (TNBC), subtype associated with aggressive clinical...
Abstract Introduction: Antibody and peptide-conjugated drugs are rapidly entering the clinic for treatment of patients with early advanced breast cancer. These designed to achieve more targeted delivery cytotoxic agents tumor cells robust clinical activity. ARB-1-6, a sortilin (SORT1) peptide conjugated agent MMAE, has demonstrated pre-clinical activity tolerability in cell line xenografts To further characterize its spectrum antitumor biomarker correlates we evaluated ARB-1-6 collection...
Abstract The most aggressive B-cell lymphomas frequently manifest extranodal distribution and carry somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 skew humoral immune response towards generating abnormal immature memory B-cells (MB), while impairing plasma cell differentiation. At molecular level, mutants co-opt SMRT/HDAC3 repressor complexes binding MB transcription factor (TF) BACH2, at expense of germinal center (GC) TF BCL6, leading to pre-memory...