A5101994092- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Fungal Infections and Studies
- Neurosurgical Procedures and Complications
- Cancer, Hypoxia, and Metabolism
- Neutropenia and Cancer Infections
- Spinal Dysraphism and Malformations
- Colorectal Cancer Screening and Detection
- Healthcare Systems and Technology
- Advanced MRI Techniques and Applications
- Urinary and Genital Oncology Studies
- Child and Adolescent Health
- Health and Medical Research Impacts
- Genetic factors in colorectal cancer
- Adolescent and Pediatric Healthcare
- Gastric Cancer Management and Outcomes
- Antifungal resistance and susceptibility
- Advances in Oncology and Radiotherapy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Advanced NMR Techniques and Applications
- Cervical and Thoracic Myelopathy
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cerebrospinal fluid and hydrocephalus
Clinical Trials New Zealand
2021
Stoke Mandeville Hospital
2019
University of Cambridge
2017-2019
Buckinghamshire Healthcare NHS Trust
2019
Cancer Research UK
2017
Cancer Research UK Cambridge Center
2016
Royal Children's Hospital
1997
Fred Hutch Cancer Center
1993
Royal College of Physicians
1976
King's Fund
1976
Abstract Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we a direct requirement for the androgen receptor (AR) maintain HR gene expression and activity cancer. We show that PARP-mediated repair pathways are upregulated cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of is essential survival cells synthetic lethality between ADT inhibition vivo....
The 2015 National Institute for Health and Care Excellence guidelines widened the referral criteria two-week-wait pathway suspected lower gastrointestinal cancer. We implemented a straight-to-test protocol to accommodate anticipated increase in referrals. evaluated impact of these changes relevant metrics clinical outcomes using retrospective cohort study with historic controls.We analysed data from all patients referred teaching hospital via cancer under previous between 1 March 31 August...
Superfi cial bladder tumors are the most prevalent form of cancers and transurethral resection is primary surgical modality for those tumors.However, nearly 65% patients will have tumor recurrence in fi ve years while about 15% progression to muscle invasion.Thus, therapeutic aim prevent multiple recurrences a more advanced, invasive disease.We here report an 87-year-old white male patient with cancer who received unconventional oral regimen D-fraction, bioactive extract Maitake mushroom...
Care management for children with complex care needs in the hospital setting is not just about managers developing and maintaining partnerships between community professionals, their families. It also requires organizational commitment to a system which patient centred, recognizes parental expertise offers clinical skills are co-ordinated across specialty areas.
Abstract Clinical studies have shown the improved benefit of combining androgen deprivation therapy (ADT) with radiotherapy, indicating a potential interaction between signalling and DNA damage response (DDR) pathways in PCa. We explored underlying basis this by interrogating mechanism regulation DDR men PCa, both untreated treated an inhibitor. show that receptor (AR) regulates promotes foci formation leading to ATM activation Our data showing AR provides explanation for outcome combined...
This work was supported by CRUK [C8742/A18097]. is a contribution from the Cancer Imaging Centre in Cambridge & Manchester, which funded EPSRC and Research UK. We would like to express our gratitude Experimental Medicine Centres (ECMC) for continued support. JK receives funding support GlaxoSmithKline.