A5080501031- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Neurosurgical Procedures and Complications
- Oral and Maxillofacial Pathology
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Bone Tumor Diagnosis and Treatments
- HIV-related health complications and treatments
- Neurogenesis and neuroplasticity mechanisms
- Scoliosis diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Syphilis Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Glioma Diagnosis and Treatment
- HIV Research and Treatment
University of Miami
2022-2025
Neurological Surgery
2024
<h3>Background</h3> Surgical management of severe thoracolumbar kyphosis (TLK) is challenging due to the necessity achieving adequate sagittal realignment without increasing operative risk or compromising hardware integrity. Performing large corrective maneuvers during deformity correction may increase neurological complications, especially when correcting hyperkyphosis in distal spine. The present article describes first use a custom-made articulating rod manipulate patient's TLK into...
Elevated brain deposits of amyloid beta (Aβ40) contribute to neuropathology and cognitive dysfunction in Alzheimer's disease (AD). However, the role blood-brain barrier (BBB) as an interface for transfer Aβ40 from periphery into is not well characterized. In addition, a substantial population neural progenitor cells (NPCs) resides close proximity capillaries that form BBB. The aim this study understand impact endothelium-derived extracellular vesicles (EV) containing on metabolic functions...
Ischemic stroke and cerebral amyloid angiopathy (CAA) pose significant challenges in an aging population, particularly post-stroke recovery. Using the 5xFAD mouse model, we explore relationship between CAA, ischemic stroke, tissue We hypothesize that amyloid-beta accumulation worsens outcomes by inducing blood-brain barrier (BBB) dysfunction, leading to impaired neurogenesis. Our findings show CAA exacerbates outcomes, with mice exhibiting constricted BBB microvessels, reduced blood flow,...
<h3>Background</h3> Adjacent segment disease (ASD) is a known sequela of thoracolumbar instrumented fusions. Various surgical options are available to address ASD in patients with intractable symptoms who have failed conservative measures. However, the optimal treatment strategy for symptomatic has not been established. We examined several clinical outcomes utilizing different interventions ASD. <h3>Methods</h3> A retrospective review was performed consecutive series undergoing revision...
Minimally invasive surgical approaches to the spine that leverage indirect decompression are gaining increasing popularity. While there is excellent literature on value of decompression, limitations this procedure. Specifically, in patients with severe stenosis and neurogenic claudication, a concern among many surgeons regarding adequacy alone. In these cases, lateral approach often abandoned favor an open posterior or minimally approach. Unfortunately, some distinct benefits direct then...
Epidural arteriovenous fistulas (eAVFs) are rare vascular malformations often mistaken for their intradural counterparts due to similar angiographic features. Differentiation between epidural and lesions is crucial as it impacts surgical planning prognosis. Despite advancements in diagnostic imaging, these entities can be misinterpreted challenge management.