A5072895200- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Dementia and Cognitive Impairment Research
- Preterm Birth and Chorioamnionitis
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Fetal and Pediatric Neurological Disorders
- Tryptophan and brain disorders
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Amyotrophic Lateral Sclerosis Research
- Morphological variations and asymmetry
University of Miami
2019-2024
Miami University
2022
King's College London
2012-2020
St Thomas' Hospital
2012-2019
Kings Health Partners
2015-2019
University of Connecticut
2008-2013
Imperial College London
2010-2012
Hammersmith Hospital
2012
Columbia University
2008
Universitat Jaume I
2008
Fetal/neonatal brain injury is an important cause of neurological disability. Hypoxia-ischemia and excitotoxicity are considered insults, and, in spite their acute nature, develops over a protracted time period during the primary, secondary, tertiary phases. The concept that most with delay after insult makes it possible to provide effective neuroprotective treatment insult. Indeed, hypothermia applied within 6 hours birth neonatal encephalopathy reduces disability clinical trials. In order...
Abstract Schizophrenia (SCZ) is a psychiatric disorder that can include symptoms of disorganized speech and thoughts with uncertain underlying mechanisms possibly linked to over‐activated microglia. In this study, we used brain samples from sixteen donors SCZ thirteen control assess the differential activation microglia by quantifying density 3D reconstruction stained ionized calcium‐binding adaptor molecule‐1 (Iba1). Our consisted sections frontal, temporal, cingulate cortical gray matter,...
Cetaceans are well-regarded as sentinels for toxin exposure. Emerging studies suggest that cetaceans can also develop neuropathological changes associated with neurodegenerative disease. The occurrence of neuropathology makes an ideal species examining the impact marine toxins on brain across lifespan. Here, we describe TAR DNA-binding protein 43 (TDP-43) proteinopathy and Alzheimer's disease (AD) in a beached harbor porpoise (
Goal-directed actions are sensitive to work-related response costs, and dopamine in nucleus accumbens is thought modulate the exertion of effort motivated behavior. Dopamine-rich striatal areas such as also contain high numbers adenosine A 2A receptors, and, for that reason, behavioral neurochemical effects receptor agonist CGS 21680 [2- p -(2-carboxyethyl) phenethylamino-5′- N -ethylcarboxamidoadenosine] were investigated. Stimulation receptors disrupted performance an instrumental task...
The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature are more severe persistent than TBI in mature brain. Understanding this developmental sensitivity is critical as children under four years of age sustain frequently any other group. Microglia (MG), resident immune cells that mediate neuroinflammation, activated following However, type temporal profile activation consequences altering it still largely unknown. In a mouse model closed head weight drop...
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity (ADHD). The mechanism gray matter injury preterm children unclear likely to be multifactorial; however, inflammation, a high predictor poor outcome infants, has been disrupted interneuron maturation number animal models. Interneurons are important for...
Perinatal brain injury is a major cause of neurodevelopmental handicaps. Multiple pathways oxidant stress, inflammation, and excitotoxicity lead to cell damage death, including caspase-dependent apoptosis. Caspase-2 (Casp2; Nedd-2, Ich-1) developmentally regulated initiator caspase, which poorly cleaves other caspases but can initiate mitochondrial outer membrane permeabilization. We have investigated if Casp2 could mediate perinatal ischemic damage.Casp2 expression in human neonatal brains...
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative that destroys memory and cognitive function. Inflammasome activation has been suggested to play critical role in the neuroinflammatory response AD progression, but cell‐type expression of inflammasome proteins brain not fully characterized. In this study, we used samples from hippocampus formation, subiculum, entorhinal cortex 17 donors with low‐level pathology intermediate assess proteins. We performed analysis hippocampal...
Abstract Schizophrenia (SCZ) is a complex psychiatric disorder that involves an inflammatory response thought to be characterized by microglial activation. The inflammasome may play critical roles in the pathomechanism of neuroinflammation but how this relates SCZ remains unclear. In study, we performed immunohistochemical (IHC) analysis compare expression proteins brain tissue from donors with (n = 16) and non-psychiatric (NP; n 13) isolated superior frontal cortex (SFC), temporal cortex,...
Toll-like receptors (TLRs) are members of the pattern recognition receptor family that detect components foreign pathogens or endogenous molecules released in response to injury. Recent studies demonstrate TLRs also have a functional role regulating neuronal proliferation developing brain. This study investigated cellular expression TLR3 using immunohistochemistry on human brain tissue. The tissue sections analysed contained anterior and lateral periventricular white matter from frontal...
Periventricular leukomalacia (PVL) is the most common form of preterm brain injury affecting cerebral white matter. This type involves a multiphase process and induced by many factors, including hypoxia-ischemia (HI) infection. Previous studies have suggested that lymphocytes play significant role in pathogenesis injury, aim this study was to determine contribution lymphocyte subsets injury.Immunohistochemistry on sections from neonatal mice performed evaluate extent wild-type T cell B...
Infection and sepsis are associated with brain white matter injury in preterm infants the subsequent development of cerebral palsy. In present study, we used a neonatal mouse sepsis-induced model to determine contribution different T cell subsets (αβT cells γδT cells) consequent behavioral changes. C57BL/6J wild-type (WT), receptor (TCR) δ-deficient (Tcrd −/−, lacking cells), TCRα-deficient (Tcra αβT mice were administered lipopolysaccharide (LPS) at postnatal day (PND) 2. Brain myelination...
Toll-like receptor-3 (TLR3) has been identified in a variety of intracellular structures (e.g. endosomes and endoplasmic reticulum); it detects viral molecular patterns damage-associated patterns. We hypothesized that, after white matter injury (WMI) occurred, localization activation TLR3 are altered gray response to activated glia. Therefore, we investigated the subcellular its downstream signaling pathway postmortem brain sections from preterm infants with without WMI (7 patients each)....
Abstract Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated deviations in cortical development evidenced by simplified gyral appearance reduced surface area. Radial glia are neuronal glial progenitors that also create a scaffolding structure essential for migrating neurons to reach targets therefore play critical role development. The aim this study was characterise radial expression pattern morphology the frontal lobe developing fetal brain DS age-matched...
Abstract INTRODUCTION Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology. METHODS We investigated protein expression, morphological differences of Ng, and correlated Ng hyperphosphorylated tau post mortem brains 17 cases age‐ sex‐matched controls. addition, we expression with two different epitopes apoptosis‐associated speck‐like containing caspase recruitment domain...
Introduction Severity and distribution of aggregated tau neurofibrillary tangles (NFT) are strongly correlated with the clinical presentation Alzheimer’s disease (AD). Clearance could decrease rate NFT formation delay AD onset. Recent studies implicate corpora amylacea (CA) as a regulator onset or accumulation pathology. Normally, CA clear brain waste products by amassing cellular debris, which then extruded into cerebrospinal fluid to be phagocytosed. The proper functioning may slow...
Ischemic stroke and cerebral amyloid angiopathy (CAA) pose significant challenges in an aging population, particularly post-stroke recovery. Using the 5xFAD mouse model, we explore relationship between CAA, ischemic stroke, tissue We hypothesize that amyloid-beta accumulation worsens outcomes by inducing blood-brain barrier (BBB) dysfunction, leading to impaired neurogenesis. Our findings show CAA exacerbates outcomes, with mice exhibiting constricted BBB microvessels, reduced blood flow,...
Neuronal heterotopia are ectopic nodules of nerve cells that failed to migrate appropriately during the early development fetal brain. Subcortical and periventricular neuronal have been described previously in association with agenesis corpus callosum (ACC). Most common migration disorders related rare genetic mutations, but ACC, basis is unknown up 55-70% cases or heterogeneous nature[1]. In this case report, we investigated a neonatal brain (ACC-H) diagnosed on antenatal MR imaging...
Dementia is a group of symptoms including memory loss, language difficulties, and other types cognitive functional impairments that affects 57 million people worldwide, with the incidence expected to double by 2040. Therefore, there an unmet need develop reliable biomarkers diagnose early brain so emerging interventions can be applied before degeneration. Here, we performed biomarker analyses for apoptosis-associated speck-like protein containing caspase recruitment domain (ASC),...
Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally catalase. acetaldehyde show differences in their behavioral effects depending upon route administration. In terms on motor activity motivated behaviors, when administered tends to more potent than but shows very similar potency centrally. Since dopamine (DA) rich areas have an...
Abstract Introduction Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive. Methods Using large‐scale transcriptomic dataset, we analyzed the neurogranin‐centered integrative gene network and assessed correlation neurogranin ( NRGN ) expression with post mortem brains. We studied association Clinical Dementia Rating (CDR) neuropathological diagnosis AD. Results find that genes positively correlated are involved...