A5004007494- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nuclear Receptors and Signaling
- Diabetes and associated disorders
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Virus-based gene therapy research
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- DNA Repair Mechanisms
- Biotin and Related Studies
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Animal Genetics and Reproduction
- Viral Infections and Vectors
- interferon and immune responses
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- CRISPR and Genetic Engineering
- Congenital Diaphragmatic Hernia Studies
- Pancreatic function and diabetes
- Mycobacterium research and diagnosis
- Gastroesophageal reflux and treatments
Texas Tech University
2025
NIHR Bristol Cardiovascular Biomedical Research Unit
2017
University of Bristol
2017
Saint Louis University
2010
Monroe Carell Jr. Children's Hospital
2006
Montreal Children's Hospital
2005
Kansas State University
2004
University of Utah
2004
Washington University in St. Louis
2004
Queen's University
1991-1993
Recent evidence has identified the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) as a regulator of cardiac energy metabolism and mitochondrial biogenesis. We describe development transgenic system that permits inducible, cardiac-specific overexpression PGC-1alpha. Expression PGC-1alpha transgene in this (tet-on PGC-1alpha) is presence doxycycline (dox) not leaky absence dox. Overexpression tet-on mice during neonatal stages leads to dramatic increase number...
The mechanism of insulin dysregulation in children with hyperinsulinism associated inactivating mutations short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined mice a knock-out the hadh gene (hadh(-/-)). hadh(-/-) had reduced levels plasma glucose and elevated levels, similar to SCHAD deficiency. were hypersensitive oral amino acid decrease level elevation insulin. Hypersensitivity can be explained by abnormal responses physiological mixture acids increased sensitivity leucine...
Genes actively involved in the G0/G1 switch (G0S genes) may be differentially expressed during lectin-induced of lymphocytes from G0 to G1 phases cell cycle. This paper presents studies G0S2, a member set putative G0S genes, for which cDNAs were cloned and selected on basis differential cDNA hybridization. G0S2 mRNA increases transiently within 1–2 hr addition lectin or cycloheximide cultured blood mononuclear cells. Comparison nearly full-length sequence with corresponding genomic reveals...
Virgin D. melanogaster females were kept at near-freezing temperatures for up to one week, whereupon they mated. Daily collections of offspring showed evidence spindle malfunction in meiosis, but not earlier mitoses, despite our usage a colder temperature (5.5˚C) than previous studies (10˚C). The greater sensitivity meiosis mitosis is baffling, considering that the opposite true males, where primary spermatocytes are most vulnerable.
Cyclosporin A (CsA) may achieve its immunosuppressive effects by inhibiting the calcium- and calmodulindependent phosphatase calcineurin which is required for activation of target genes members NFAT (nuclear factor activated T cells) transcription family. Among these gene encoding interleukin-2 (IL2), a cytokine facilitating progression through GI phase cell cycle. However, IL2 does not reverse CsA inhibition, suggesting that at least one other NFAT-sensitive be involved. The human G0/G1...
G0S3 is a member of set putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from human blood mononuclear cells cultured for 2 hr with lectin and cycloheximide. The sequence shows high homology the murine FOSB gene, which encodes component API transcriptional regulator. Comparison genomic sequences reveals 4-exon structure characteristic FOS family genes. Freshly isolated show levels FOSB/G0S3 FOS/G0S7 mRNAs, decline rapidly during incubation in...
The human G0/G1 switch (G0S) gene, G0S24, and its rodent immediate-early homolog (TIS11, TTP, NUP475) are part of a mammalian gene family whose members encode CCCH zinc finger domains similar to the large subunit RNA polymerase II Mei2 regulator G1 arrest in fission yeast. We compared expression G0S24 with that other G0S genes cultured blood mononuclear cells examined levels various processing intermediates. Freshly isolated contained high several RNAs, which declined by 24 h, suggesting...
The murine gene, MIP1α, encodes a cytokine (macrophage inflammatory protein 1α) that inhibits the proliferation of bone marrow stem cells. Two human homologs have been characterized, G0S19-1 and G0S19-2. Like these genes contain three exons, first which hydrophobic signal sequence. existence third G0S19 present in one four individuals, has predicted from restriction enzyme analyses. This paper reports previously identified genomic clone containing sequence (G0S19-3), corresponds to gene....
The GOS19-1/MIP1α and GOS19-2/MIP1α genes locate to human chromosomes 17q encode similar copies of the β-chemokine GOS19/MIP1α. GOS19-3 gene, present in 1 4 humans, is a 5′ truncated version GOS19-2; CpG island-containing upstream sequence (CpG-US), rich potential transcriptional activation motifs, replaces much first intron exon. Sequences hybridizing with CpG-US sequence, normally exist all genomes. Thus, it appears that there has been recombination between duplicated GOS19 gene...
The question "what is the prognosis of this tumour?" same as "how will tumour evolve next?".Consequently, it seems logical that efficacious prognostic and treatment-predictive biomarkers can be found by measuring evolutionary process cancer development itself.But current biomarkers, including state-of-the-art in molecular diagnostics, measure only outputs process: factors organisation, spread, shape expression profiles cells.I describe our (and others') quantify underlying dynamics evolution...