A5043708055- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Advanced Nanomaterials in Catalysis
- Adipokines, Inflammation, and Metabolic Diseases
- Chemokine receptors and signaling
- Systemic Sclerosis and Related Diseases
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Immunodeficiency and Autoimmune Disorders
- Nanocluster Synthesis and Applications
- Psoriasis: Treatment and Pathogenesis
- Alcohol Consumption and Health Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Electron Microscopy Techniques and Applications
- S100 Proteins and Annexins
- Structural Integrity and Reliability Analysis
- Angiogenesis and VEGF in Cancer
- Inflammation biomarkers and pathways
- Esophageal and GI Pathology
University of Science and Technology of China
2024-2025
Hefei Institutes of Physical Science
2024-2025
High Magnetic Field Laboratory
2024-2025
Chongqing Three Gorges Central Hospital
2024
Chongqing University
2024
Asthma UK
2012-2014
King's College London
2008-2014
Imperial College London
2013
ENT and Allergy
2011
Oregon Health & Science University
2009
Purpose: Pueraria lobata (P. lobata) , a dual-purpose food and medicine, displays limited efficacy in alcohol detoxification liver protection, with previous research primarily focused on puerarin its dried roots. In this study, we investigated the potential effects mechanisms of fresh P. root-derived exosome-like nanovesicles (P-ELNs) for mitigating alcoholic intoxication, promoting metabolism protecting C57BL/6J mice. Methods: We isolated P-ELNs from root using differential centrifugation...
Abstract Single‐atom nanozymes (SAzymes) with low coordination structure has more active sites at an atomic level, which is one of the effective strategies to improve efficiency tumor catalytic therapy. Herein, it reported that simple preparation single‐atom manganese‐doped carbon dots (SA Mn‐CDs) (Mn‐N 2 ) configuration formed by chelating manganese atoms ethylenediamine tetraacetic acid (EDTA). SA Mn‐CDs show good dispersibility different solvents, excellent biological safety and...
RELM-β has been implicated in airways inflammation and remodelling murine models. Its possible functions human are largely unknown. The aim was to address the hypothesis that plays a role extracellular matrix deposition asthmatic airways.The effects of gene deficiency were studied model allergen exposure mice sensitised challenged with Aspergillus fumigatus (Af). expression investigated bronchial biopsies from patients. Direct regulatory on lung fibroblasts examined using primary cultures...
Though implicated in vascular remodelling, a role for the resistin-like molecule (RELM)-β human airway remodelling remains unexplored. We hypothesised that RELM-β expression is increased airways of asthmatics and regulates epithelial cell function. Expression bronchial mucosa its concentrations bronchoalveolar lavage (BAL) fluid from controls were measured by immunohistochemistry ELISA, respectively. Proliferation assays, Western blotting, ELISA real-time PCR employed to detect effects on...
Unlike other IL-17 family members, the Th2-derived cytokine IL-25 (IL-17E) induces (promotes) Th2 responses. One or both of two receptors for (IL-17RA, IL-17RB) is expressed on inflammatory cells and tissue structural cells, suggesting that in addition to promoting Th2-type inflammation may also act at sites such as asthmatic bronchial mucosa promote remodelling changes.Our previous studies showed elevated expression IL-17RB immunoreactivity airways with co-localization latter endothelial...
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder accompanied by ovulatory dysfunction. Insulin resistance (IR) a key pathogenic mechanism in PCOS, insulin sensitizers, such as metformin pioglitazone, can improve PCOS symptoms. Chiglitazar, pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist, also sensitizer; however, its therapeutic effects have not yet been studied PCOS. We evaluated the of chiglitazar rat model Sprague–Dawley rats aged 4 weeks were...
Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – 30,