A5083449898- Enzyme function and inhibition
- Garlic and Onion Studies
- Powdery Mildew Fungal Diseases
- Biological Stains and Phytochemicals
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Nuts composition and effects
- HER2/EGFR in Cancer Research
- Microtubule and mitosis dynamics
- Synthesis and Catalytic Reactions
- Chemical Reactions and Isotopes
- Plant Pathogens and Fungal Diseases
- Plant-Derived Bioactive Compounds
- Cancer Research and Treatments
- Synthesis and biological activity
- Photodynamic Therapy Research Studies
- Chemical Synthesis and Analysis
- Cancer-related Molecular Pathways
- Skin Protection and Aging
- Quinazolinone synthesis and applications
Philipps University of Marburg
2017-2025
Background: Photodynamic therapy (PDT) has evolved as a reliable therapeutic modality for cancer. However, the broad application of technique is still limited because poor bioavailability and non-selective distribution photosensitizers within host tissues. Herein, zein, natural corn protein, was functionalized with glycyrrhetinic acid (GA) polyethylene glycol (Z-PEG-GA) targeting platform liver cancer cells. Parietin, novel photosensitizer, successfully encapsulated into zein via...
Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant with lower probability of developing or systemic toxicity commonly associated the standard antibiotic treatment. Parietin (PTN), also termed physcion, natural anthraquinone, is promising photosensitizer somewhat underrepresented aPDT because its poor water solubility and...
Some novel sulfonamide-derivatives were designed to develop kinase inhibitors. The molecular docking study was performed for the compounds against epidermal growth factor receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) identify new drug candidates treating cancer. Binding free energy calculated by Molegro virtual docker (MVD) select most promising hits. corresponding score values into EGFR of 4b gave best -147.213 Kcal/mol. And some sulfonamide derivatives have been synthesized conventional...
Researchers have discovered that tyrosine kinase plays a significant role in cancer development. As result, certain studies focused on synthesizing sulfonamide compounds due to their potent inhibitory (TKI). The designed were docked against (HER2) human epidermal growth factor receptor 2 (PDB ID: 3pp0) identify potential prospects for new drugs. Docking using Molegro virtual docker (MVD) revealed the most favorable binding energy among our compounds. In total, all synthesized had energies...
Some new azo dye derivatives have been designed for the development of novel kinase inhibitors. A molecular docking study compounds against Aurora (PDB: 3K5u) was conducted to identify drug candidates cancer therapy. The binding free energy calculated by Molegro virtual docker (MVD) select most promising results. corresponding score values in compound 4 gave best -123.2 kcal/mol and 1 -88 kcal/mol. Compound gaven bindings following amino acids Ala213, Ala273, Lys162, Asn261 Thr217. These...
Introduction: Pistacia palaestina Boiss. leaves are rich in bioactive compounds with potential wound healing properties. Objective: The current study evaluated the properties of 70% methanol extract leaves, as well its hexane, chloroform, ethyl acetate, and aqueous fractions derived from crude extract. Methods: investigation activity was conducted using dermal incision model rats. Evaluation acute irritation/corrosion following guidelines outlined Organization for Economic Cooperation...
Human Carbonic anhydrase IX is often found to be over-expressed in solid tumors, and plays a role helping cancer cells adapt grow under Hypoxic conditions, by exacerbating the extracellular acidification which enables develop resistance against chemotherapy. Many molecules were studied as CAIX inhibitors. Ureido-Substituted benzenesulfonamides (UBSs) are promising CA inhibitors used treatments. (SLC-0111) one of that has shown tolerability safety patients previously Treated for tumors. The...
Common onion (Allium cepa) is considered as one of the most important vegetables.1 Some bacteria and fungi can infect spoil bulbs within a short period time.2 The early stages infection cannot be detected in onions by conventional analytical methods. It assumed that pattern chemical compounds altered action pathogenic fungi. In this project, four types microorganisms (Fusarium oxysporum, Fusarium proliferatum, Penicillium sp, Botrytis aclada) were tested to elucidate identify volatile...