A5054948047- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Burn Injury Management and Outcomes
- Animal Diversity and Health Studies
- Abdominal Surgery and Complications
- Eosinophilic Esophagitis
- Cardiovascular Disease and Adiposity
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Immune Cell Function and Interaction
- Intraocular Surgery and Lenses
- IL-33, ST2, and ILC Pathways
- Rheumatoid Arthritis Research and Therapies
- Traditional and Medicinal Uses of Annonaceae
- Spinal Fractures and Fixation Techniques
- Polymer Surface Interaction Studies
- Breast Implant and Reconstruction
- Cerebrovascular and Carotid Artery Diseases
- Lymphatic System and Diseases
- Sexual function and dysfunction studies
- Bee Products Chemical Analysis
- Phytochemistry and Bioactive Compounds
- Agriculture and Biological Studies
- Phytochemical compounds biological activities
- Medical Imaging and Analysis
Al-Azhar University
2014-2025
Ain Shams University
2014-2025
University of Miami
2024-2025
Philipps University of Marburg
2020-2023
The University of Texas Health Science Center at San Antonio
2023
Cairo University
2023
Mansoura University
2011
Antimicrobial strategies with high efficacy against bacterial infections are urgently needed. The development of effective therapies to control is still a challenge. Herein, near-infrared (NIR)-activated thermosensitive liposomes (TSL) were loaded the NIR-dye 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) and water-soluble hypericin (Hyp) β-cyclodextrin inclusion complex (Hyp-βCD). DiR Hyp-βCD (DHβCD-TSL) functionalized for photothermal triggered release synergistic...
<title>Abstract</title> Oral administration remains the most accessible and patient-friendly route for drug delivery. Paclitaxel, a potent anticancer agent sourced from natural origins, presents highly lipophilic profile, demonstrates substantial antineoplastic efficacy across various malignancies. However, its clinical application is limited by intrinsic hurdles, including low solubility, systemic toxicity, bioavailability. In this study, we engineered folate-modified zein nanoparticles...
Background: Photodynamic therapy (PDT) has evolved as a reliable therapeutic modality for cancer. However, the broad application of technique is still limited because poor bioavailability and non-selective distribution photosensitizers within host tissues. Herein, zein, natural corn protein, was functionalized with glycyrrhetinic acid (GA) polyethylene glycol (Z-PEG-GA) targeting platform liver cancer cells. Parietin, novel photosensitizer, successfully encapsulated into zein via...
Background Flow-diverter stents (FDS) have become the standard of care for a wide range intracranial aneurysms, but their efficacy/safety in context recurrent/recanalized aneurysms following stent-assisted coiling (SAC) is not well established. We evaluate outcomes FDS retreatment large multicenter cohort. Methods retrospectively analyzed data from 118 patients across 22 institutions who underwent recurrent/persistent after SAC (2008–22). The primary outcome was angiographic occlusion status...
In this study, the potential cytotoxicity of four plant extracts originated from Cameroon: Xylopia aethiopica (XA), Imperata cylindrica (IC), Echinops giganteus (EG) and Dorstenia psilurus (DP) were examined in vitro. We tested anti-proliferative activity methanolic these compounds using MTT assay on seven different human cancer cell lines: HeLa, MDA-MB-231, A549, HepG2, U-87, SK-OV-3 HL60. Induction death was assessed by cycle analysis, apoptosis determined Annexin V-FITC binding caspase...
Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant with lower probability of developing or systemic toxicity commonly associated the standard antibiotic treatment. Parietin (PTN), also termed physcion, natural anthraquinone, is promising photosensitizer somewhat underrepresented aPDT because its poor water solubility and...
The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in susceptibility and/or disease profile rheumatoid arthritis (RA) Egyptian patients. TNF-α-308 G/promoter detection by amplification refractory mutation system (ARMS) technique carried out for 122 RA patients and 120 healthy controls. G allele/GG homozygous genotype were higher with than those control group (P < 0.001, respectively). A statistically significant...
Background Ever since lipoabdominoplasty was first developed to achieve better aesthetic outcomes and less morbidity, the rate of seroma formation, especially in obese patients, has disturbed plastic surgeons. The aim this study evaluate effect fibrin sealant prevention formation after patients. Methods Sixty patients with a body mass index (BMI) between 30 39.9 were assigned randomly 1 2 groups (30 each). Group A underwent glue, while group B traditional lipoabdominoplasty; both had closed...
An IFNγ-susceptible mutant of
Abstract Introduction Massive burn patients are at high risk of developing intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as a complication aggressive resuscitation. This study aimed to evaluate the effect Hydroxyethyl starch (HES) versus 5% albumin solution on pressure (IAP) in massive patients. Methods was single-center, prospective randomized clinical trial carried Ain Shams University (ASU) unit for 2 years. Where adult with burns 20 60 % TBSA were equally...
Abstract Background Vitamin D is a steroid hormone that plays crucial role in mineral homeostasis and bone metabolism. Recent studies have revealed its diverse the immune system, vascular myocardial cells. deficiency insufficiency are frequently observed children adolescents worldwide, particularly Middle East. Cardiovascular disease (CVD) leading cause of mortality, ischemic heart (IHD) major contributor to global burden. The current study aimed assess vitamin IHD patients. Aim Work...
Abstract An IFNγ-susceptible mutant of Chlamydia muridarum is attenuated in pathogenicity the genital tract and recently licensed as an intr acellular O ral vaccine v ector or intrOv. Oral delivery intrOv induces transmucosal protection but itself cleared from gut (without shedding any infectious particles externally) by IFNγ group 3-like innate lymphoid cells (ILC3s). We further characterized interactions with ILC3s current study since may impact both safety efficacy oral vaccine....
Abstract Background Atherosclerosis is the ongoing process of plaque formation involving primarily intima large and medium-sized arteries. The condition progresses relentlessly throughout a person’s lifetime, before finally manifesting itself as an acute ischemic event. TIMI score tool 7 points for patients with NSTE-ACS to detect risk according score. term coronary syndrome (ACS) includes unstable angina (UA), non STsegment elevation myocardial infarction (NSTEMI), ST-segment (STEMI). Aim...
Abstract Background The ability of topical heparin application to improve the healing outcome burn wounds has been demonstrated by several studies. However, its impact on skin graft donor site was not studied. Aim present study done compare (healing time, pain, itching, scarring and complications) treatment with conventional in areas after grafting patients. Methods This prospective, interventional, controlled, single-blinded clinical 40 patients 2nd or 3rd degree burns any etiology...
Background Data: Lumbar spondylolisthesis is a common condition. Indications for surgery other than failure of conservative treatment include progressive neurological deficits, intractable and symptomatic spinal instability. Surgical options posterior interbody fusion posterolateral fusion.Purpose: To compare the difference in results between lateral inter-transverse (PLF) alone lumbar (PLIF) regarding clinical outcome rate. Study Design: This retrospective randomized comparative study....